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Is Genetic Drift to Blame for Testicular Dysgenesis Syndrome in Semliki Chimpanzees (Pan Troglodytes Schweinfurthii)? Public Deposited

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MLA citation style

Hunt, Kevin D, et al. Is Genetic Drift to Blame for Testicular Dysgenesis Syndrome In Semliki Chimpanzees (pan Troglodytes Schweinfurthii)?. . 5252. https://mushare.marian.edu/concern/generic_works/aedaf7dc-5a6a-4c6e-beb1-58818560af37?locale=en

APA citation style

Hunt, Kevin D, Deimel, Caroline, Kaestle, Frederika, Wasserman, Michael D, Rich, Alicia M, & Breeden, Scott K. OMS-4. (5252). Is Genetic Drift to Blame for Testicular Dysgenesis Syndrome in Semliki Chimpanzees (Pan Troglodytes Schweinfurthii)?. https://mushare.marian.edu/concern/generic_works/aedaf7dc-5a6a-4c6e-beb1-58818560af37?locale=en

Chicago citation style

Hunt, Kevin D., Deimel, Caroline, Kaestle, Frederika, Wasserman, Michael D., Rich, Alicia M., and Breeden, Scott K. OMS-4. Is Genetic Drift to Blame for Testicular Dysgenesis Syndrome In Semliki Chimpanzees (pan Troglodytes Schweinfurthii)?. 5252. https://mushare.marian.edu/concern/generic_works/aedaf7dc-5a6a-4c6e-beb1-58818560af37?locale=en

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Background We present 3 likely cases of testicular dysgenesis syndrome (TDS) within a community of chimpanzees (<em>Pan troglodytes schweinfurthii</em>). We tested whether genetic drift may be the culprit, as a genetic cause has been suspected to account for TDS among other wildlife. Methods: We successfully sequenced a 367?bp segment spanning the first hypervariable region within the D?loop of the mitochondrial genome for 78 DNA samples. Results: We found 24 polymorphic sequence sites consisting of 7 singletons and 17 parsimony informative sites. This sample contained 9 haplotypes with a diversity index of 0.78 (SD = 0.03). All tests against the null hypothesis of neutral polymorphisms were non?significant (<em>P</em> > .10). The mismatch distribution of pairwise differences does not fit a Poisson's curve (raggedness index = 0.166; SSD = 0.12; <em>P</em> = 1). Conclusions: Thus, we found no significant signs of genetic isolation, population expansion, or genetic bottleneck. Alternative causes of TDS and how they might pertain to this population are discussed.

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  • mucom_spr_27
  • Journal of Medical Primatology
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