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Klotho in Aging and Disease Publique Deposited

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MLA citation style

Choe, David, MacLean, Andrew, and Delery, Elizabeth. Klotho In Aging and Disease. . 2021. https://mushare.marian.edu/concern/generic_works/d3bc20e0-6957-457a-8568-89e646212357?locale=fr

APA citation style

Choe, David, MacLean, Andrew, & Delery, Elizabeth. (2021). Klotho in Aging and Disease. https://mushare.marian.edu/concern/generic_works/d3bc20e0-6957-457a-8568-89e646212357?locale=fr

Chicago citation style

Choe, David, MacLean, Andrew, and Delery, Elizabeth. Klotho In Aging and Disease. 2021. https://mushare.marian.edu/concern/generic_works/d3bc20e0-6957-457a-8568-89e646212357?locale=fr

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Klotho is a regulatory anti-aging protein that is significantly expressed in the choroid plexus, plays an important role in regulating the immune response in the CNS, and diminishes with age. Klotho deficiency is characterized by significant neuroinflammation, oxidative damage in the neural parenchyma, and decline in neurocognitive functions. The choroid plexus is a reservoir for HIV, and as HIV infection can cause HIV-associated neurocognitive disorders (HAND)—an inflammaging phenotype, we hypothesized that klotho may play a role in the development of this neurocognitive deficit. Approximately 30-60% of adults with HIV develop HAND (Rosca 2021). In this project, we sought to characterize patterns of age-related klotho decline in primates as well as to determine if there was a correlation between klotho expression in the choroid plexus and HIV infection.

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