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Klotho in Aging and Disease

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MLA citation style (9th ed.)

MacLean, Andrew, Choe, David, and Delery, Elizabeth. Klotho In Aging and Disease. . 2021. mushare.marian.edu/concern/generic_works/d3bc20e0-6957-457a-8568-89e646212357?locale=pt-BR.

APA citation style (7th ed.)

M. Andrew, C. David, & D. Elizabeth. (2021). Klotho in Aging and Disease. https://mushare.marian.edu/concern/generic_works/d3bc20e0-6957-457a-8568-89e646212357?locale=pt-BR

Chicago citation style (CMOS 17, author-date)

MacLean, Andrew, Choe, David, and Delery, Elizabeth. Klotho In Aging and Disease. 2021. https://mushare.marian.edu/concern/generic_works/d3bc20e0-6957-457a-8568-89e646212357?locale=pt-BR.

Note: These citations are programmatically generated and may be incomplete.

Klotho is a regulatory anti-aging protein that is significantly expressed
in the choroid plexus, plays an important role in regulating the immune
response in the CNS, and diminishes with age. Klotho deficiency is characterized by significant neuroinflammation, oxidative damage in the neural parenchyma, and decline in neurocognitive functions. The choroid plexus is a reservoir for HIV, and as HIV infection can cause HIV-associated neurocognitive disorders (HAND)—an inflammaging phenotype, we hypothesized that klotho may play a role in the development of this neurocognitive deficit. Approximately 30-60% of adults with HIV develop HAND (Rosca 2021). In this project, we sought to characterize patterns of age-related klotho decline in primates as well as to determine if there was a correlation between klotho expression in the choroid plexus and HIV infection.

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