Role of CaMKK2 in Mechanical Stimulation of Bone

Bello, Margaret; Williams, Justin; Bellido, Teresita; Sankar, Uma; Patel, Sheel; Warrick, Adam; Robling, Alexander; Thompson, William; Shutter, Jennifer

Generic Work

Role of CaMKK2 in Mechanical Stimulation of Bone Public Deposited

MLA citation style

Bello, Margaret , et al. Role of Camkk2 In Mechanical Stimulation of Bone. . 2021. https://mushare.marian.edu/concern/generic_works/a415e73b-0cae-410a-8181-84c4201e5907?locale=en

APA citation style

Bello, Margaret, Williams, Justin, Bellido, Teresita, Sankar, Uma, Patel, Sheel, Warrick, Adam, Robling, Alexander, Thompson, William, & Shutter, Jennifer. (2021). Role of CaMKK2 in Mechanical Stimulation of Bone. https://mushare.marian.edu/concern/generic_works/a415e73b-0cae-410a-8181-84c4201e5907?locale=en

Chicago citation style

Bello, Margaret , Williams, Justin , Bellido, Teresita , Sankar, Uma, Patel, Sheel, Warrick, Adam , Robling, Alexander et al. Role of Camkk2 In Mechanical Stimulation of Bone. 2021. https://mushare.marian.edu/concern/generic_works/a415e73b-0cae-410a-8181-84c4201e5907?locale=en

Note: These citations are programmatically generated and may be incomplete.

There is a need for anabolic therapies to treat degenerative bone diseases. Mechanical loading stimulates anabolic and inhibits catabolic pathways of bone leading to increased bone formation. Osteocytes are the bone cell type responsible for coordinating the mechano-stimulatory pathways in bone. Calcium/ calmodulindependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase with roles in bone remodeling. CaMKK2 global deletion results in lower osteoclast differentiation and higher osteoblast formation and activity.

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