Kristy Wilson, Ph.D.
Genetics and Genomics
OST3 is a yeast gene for Obligosaccharyl transferase, a homolog of the Magnesium Transport 1 gene in humans. This human gene produce XMEN disease. XMEN disease is an X-Linked immune system deficiency where the amount of CD4+ T cells present in the body are reduced in function. XMEN is caused by a mutation in the MAGT1 gene. The MAGT1 gene produces a protein called magnesium transport. As shown in Magnesium transport is important because it activates CD4+ T cells, allowing for infections to be effectively detected. A mutation in the MAGT1 gene, reduces the function and effectivity of CD4+ T cells. For the individual, this mutation would result in a higher risk of developing infection, pneumonia or cancer. The only known effective treatment for XMEN is stem cell therapy.
Copyright 2018 Ariyanna Casey
Casey, Ariyanna, "Enabling Study of Human Immune Dysfunction Using Yeast Gene 0ST3/UNGI" (2018). Undergraduate Research Symposium (URS). 1.