Title

Is Genetic Drift to Blame for Testicular Dysgenesis Syndrome in Semliki Chimpanzees (Pan Troglodytes Schweinfurthii)?

Document Type

Article

Publication Date

5-25-2018

Published In / Presented At

Journal of Medical Primatology

Disciplines

Genetic Phenomena | Medicine and Health Sciences | Other Animal Sciences

Abstract

Background

We present 3 likely cases of testicular dysgenesis syndrome (TDS) within a community of chimpanzees (Pan troglodytes schweinfurthii). We tested whether genetic drift may be the culprit, as a genetic cause has been suspected to account for TDS among other wildlife.

Methods

We successfully sequenced a 367‐bp segment spanning the first hypervariable region within the D‐loop of the mitochondrial genome for 78 DNA samples.

Results

We found 24 polymorphic sequence sites consisting of 7 singletons and 17 parsimony informative sites. This sample contained 9 haplotypes with a diversity index of 0.78 (SD = 0.03). All tests against the null hypothesis of neutral polymorphisms were non‐significant (P > .10). The mismatch distribution of pairwise differences does not fit a Poisson's curve (raggedness index = 0.166; SSD = 0.12; P = 1).

Conclusions

Thus, we found no significant signs of genetic isolation, population expansion, or genetic bottleneck. Alternative causes of TDS and how they might pertain to this population are discussed.

Rights

Copyright 2018 all authors

DOI

https://doi.org/10.1111/jmp.12352

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