Bone Grafting Technologies: Current and Prospective Therapies

Document Type


Publication Date



Medicine and Health Sciences


It is estimated that more than 500,000 bone grafting surgeries occur yearly in the US to repair or replace defects caused by trauma, tumor resection, pathological degeneration and congenital malformations. Significant progress has been made in recent years to increase the technologies available for treating bone defects; however, because the field is vast and rapidly advancing, it is opportune to survey the technologies currently available and highlight promising future strategies. We performed a comprehensive literature review and subsequently divided the field into three areas: autografts, which are the gold standard in bone grafting, where bone tissue is harvested from another location in the body; allografts, which are bone grafts taken from cadavers or animals, that avoid the risks associated with autografts such as infection and donor site morbidity but have a high propensity for failure; and intelligently-engineered bone graft substitutes designed to improve graft incorporation. We also highlight advances in 3D printing, incorporation of stem cells, growth factors, and biomaterial scaffolds into bone grafting technologies. Our work is a timely summarization of the field and will assist clinicians and scientists in designing appropriate treatment strategies for patients requiring bone grafts.


Copyright all authors

This document is currently not available here.