Dr. Colleen L. Doci
Medicine and Health Sciences
•Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. •HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage diagnoses and poor prognoses for patients. •CBX5 is downregulated highly metastatic breast cancers and may repress metastatic phenotypes •It is unclear what role is may have in HNSCC, or which specific functions of CBX5 drive its antimetastatic role. •We aim to map molecular changes to phenotypic expression in order to provide better diagnostic prognoses for different HNSCC cell types as well as possible pharmacologic targets for treatment.
Copyright 2020 All Authors
Main, Kegan OMS-2; Zemkewicz, John; and Doci, Colleen L. Ph.D, "The Role of CBX5 in Head and Neck Cancer Cell Phenotypic Expression" (2020). MU-COM Research Day. 170.