Effects of Aging on Skeletal Muscle Hypertrophy

Faculty Advisor

Loren Bertocci Ph.D

Document Type


Publication Date



Medicine and Health Sciences


Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function would be expected to have a magnified negative impact. Sarcopenia, an age-dependent loss of motor nerves, leading by necessity to a coincident loss of muscle mass, would have exactly this kind of effect. Results: This age-dependent disorder may be the result of aberrant mTOR signaling, irregular miRNAs content, malnutrition and lack of activity, and age-related inflammation. It may be possible to reduce the effects of sarcopenia via strength training, as well as increasing daily intakes of protein, essential amino acids, and fish oils. Combining the consumption of whey protein, which is high in leucine, and poly-unsaturated fatty acids with strength training resulted in increases in muscle mass and strength. Objective: This review examines the existing causes and effects of age-related sarcopenia, as well as methods that might ameliorate problems associated with age-related sarcopenia.


Copyright 2019 all authors

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