A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines
Medicine and Health Sciences
Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super family, include multiple subtypes (α, β/δ and g) whose proteins serve a function in cell growth and differentiation. PPARδ is also a potential downstream target of the tumor suppressor gene adenomatous polyposis coli (APC), most commonly found mutated in a variety of solid tumor cancers. This makes PPAR a potential target for chemotherapeutic intervention as PPAR activation promotes tumor genesis by increasing cell proliferation. Since there is a relationship between PPAR activation and cancer, we sought to evaluate a novel PPAR δ/g agonist and explore whether this compound could alter apoptosis induced with known chemotherapeutic compounds.
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Fein, A. OMS-2; Rahman, R. OMS-2; Gleason, S. OMS-4; Brinkman, H. OMS-2; Ristic, M. OMS-4; Do, A. OMS-4; Boncher, T.; and Strom, David Ph.D, "A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines" (2018). MU-COM Research Day. 103.