Title
A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines
Document Type
Poster
Publication Date
11-9-2018
Disciplines
Medicine and Health Sciences
Abstract
Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super family, include multiple subtypes (α, β/δ and g) whose proteins serve a function in cell growth and differentiation. PPARδ is also a potential downstream target of the tumor suppressor gene adenomatous polyposis coli (APC), most commonly found mutated in a variety of solid tumor cancers. This makes PPAR a potential target for chemotherapeutic intervention as PPAR activation promotes tumor genesis by increasing cell proliferation. Since there is a relationship between PPAR activation and cancer, we sought to evaluate a novel PPAR δ/g agonist and explore whether this compound could alter apoptosis induced with known chemotherapeutic compounds.
Rights
Copyright 2018 all authors
Recommended Citation
Fein, A. OMS-2; Rahman, R. OMS-2; Gleason, S. OMS-4; Brinkman, H. OMS-2; Ristic, M. OMS-4; Do, A. OMS-4; Boncher, T.; and Strom, David Ph.D, "A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines" (2018). MU-COM Research Day. 103.
https://mushare.marian.edu/mucom_rd/103
