Title

A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines

Authors

Document Type

Poster

Publication Date

11-9-2018

Abstract

Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super family, include multiple subtypes (α, β/δ and g) whose proteins serve a function in cell growth and differentiation. PPARδ is also a potential downstream target of the tumor suppressor gene adenomatous polyposis coli (APC), most commonly found mutated in a variety of solid tumor cancers. This makes PPAR a potential target for chemotherapeutic intervention as PPAR activation promotes tumor genesis by increasing cell proliferation. Since there is a relationship between PPAR activation and cancer, we sought to evaluate a novel PPAR δ/g agonist and explore whether this compound could alter apoptosis induced with known chemotherapeutic compounds.

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Copyright all authors

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