COM Research Day is an annual showcase of the the research engagement of the students within the College of Osteopathic Medicine. Content on display are typically poster presentations along with faculty-led discussions of research projects. This event is coordinated by the MU-COM Research Club as well as the Faculty-led Research Club Committee.

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Submissions from 2018

Survey of Bacterial Populations and Associated Antimicrobial Resistance in the Nina Mason Pulliam Ecolab (NMPE), Azeem Ahmad Ph.D, Samina Akbar Ph.D, Megan Desrosiers, and Bridgette Antolin

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The Role of α2δ1 in Mediating Extracellular Signaling in Retinal Cells, Cecelia Bender OMS-2, Collin Young OMS-1, Marian University - Indianapolis, and Julia Hum Ph.D

3D Printing Phone Case Orbs to Bend Light as a Geospatial Fitness Incentive, Joe Bondi OMS-2 and Sage Arbor Ph.D

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Effects of Hypothyroidism on Articular Cartilage in Juvenile Swine, Joshua Bundy, Dennis Weiner MD, Julianne Yang MD, Robin Childs MS, Melanie Morscher PT, Richard Steiner Ph.D, Mark Adamczyk MD, and William Landis Ph.D

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Bovine Arch Anatomy Influences Recoarctation Rates in the Era of the Extended End-to-End Anastomos, Nicholas B. Cavanaugh OMS-3, Brian D. Conway, Osamah Aldoss, Ben E. Reinking, Nicholas P. Rossi, Ahmed El-Hattab, and Joseph W. Turek

Intravenous Ketorolac and Intravenous Acetaminophen Effect on Kidney Function and Morphine Intake During Postoperative Laparoscopic Bariatric Surgery at Maui Memorial Medical Center, Joseph Chasen OMS-2, Chelsea Machida, Dan York Ph.D, and Arthur Chasen MD

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Role of Protein Kinase-C and Rho Kinase in the Cytotoxic Effects of Bitter Melon Extract on Metastatic Breast Cancer Cells, Heeyun Choi and Bhupal Bhetwal Ph.D

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Fruit and Vegetable Consumption of Adolescents, Jacob Conroy OMS-1, Rachel Krallman, Daniel Montgomery, Jean DuRussell-Weston, Eva Kline-Rogers, Kim A. Eagle, and Elizabeth A. Jackson

Impulse Oscillometry Pulmonary Function Abnormalities in Sickle Cell Disease, Lorene Cudjoe OMS-2, Payal Shah MS, Roberta M. Kato MD, and Thomas Coates MD

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Building an Epigenetic Database: Reproducibility and Orthogonal Targets, Ariel Dryden OMS-3, Eric Zhang OMS-2, Scott Given OMS-2, and Sage Arbor Ph.D

A Putative PPAR d/g Agonist Induces Apoptotic Cell Death in Human Cancer Cell Lines, A. Fein OMS-2, R. Rahman OMS-2, S. Gleason OMS-4, H. Brinkman OMS-2, M. Ristic OMS-4, A. Do OMS-4, T. Boncher, and David Strom Ph.D

Bone-derived Sclerostin Regulates Glucose Metabolism Via Endocrine Actions in Pancreatic β- cells, Adam Ferrari, Jessica H. Nelson, Kevin McAndrews, Meloney Cregor, Carmella Evans-Molina, Teresita Bellido, and Jesus Delgado-Calle

Perceptions of Appointment Time and Associations with Patient Arrival and Reminder System Preferences, Scott J. Given OMS-2 and Deanna R. Willis MD, MBA

Identification of Commercially Available Antibodies That Block Ligand-Binding by BMPR2, Ruthann E. Gorrell, Laura J. Schoerning OMS-4, Jordan B. Newby, Madeline H. Totten, Sydni N. Yates OMS-2, Logan J. Geyman, Warren G. Lawless OMS-4, Aaron M. Hudnall OMS-4, Julia M. Hum Ph.D, and Jonathan W. Lowery Ph.D

Role of Lipid Droplets in Prostaglandin E2 Production During Coxiella Burnetii Infection, Morgan E. Harrison OMS-2 and Minal Mulye Ph.D

Non-Hodgkin Lymphoma Treatments and Associated Infectious Processes, Katelyn Heaton and Inaia Phoenix Ph.D

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Effects of Aging on Muscle Hypertrophy, Jake Herber and Loren Bertocci

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Directly Targeting HIF Activity Controls FGF23 Expression Revealing Translational Considerations for CKD-related Anemia, Julia Hum Ph.D, Bryan Wacker OMS-1, and Vince Marshall OMS-1

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Elucidating the Molecular Signatures Associated with Elevated Bone Formation Rate, Kelli Jestes, Krista Jackson OMS-1, and Jonathan W. Lowery Ph.D

Investigating the Novel Redox Active Thioredoxin-like Protein (PbTrxL-1) of the Malaria Parasite Plasmodium, Nooreen Khan OMS-1 and Stefan M. Kanzok Ph.D

Coxiella Burnetii Infection Increases Cyclooxygenase Levels in Alveolar Macrophages, Blake Leeds OMS-2 and Minal Mulye Ph.D

Urinary Complications After Omitting Bladder Catheterization During Atrial Fibrillation Ablation, Andrew Lehman MPH, OMS-2; Asim Ahmed MD; and Parin Patel MD

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Lipids Droplets Play an Important Role During Obligate Intracellular Bacterial Infections, Cassandra Libbing OMS-2, Rea-Mae Azcueta, and Minal Mulye Ph.D

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The Role of Lipid Droplets in Host-pathogen Interactions of Intracellular and Extracellular Bacteria, Adam McDevitt, Ahila Ahila OMS-2, and Minal Mulye Ph.D

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Experience with and Perception of Research Among First Year Osteopathic Medical Students at Marian University, Kyle Messer OMS-2, Tim Cho OMS-2, Sarah Zahl Ph.D, and Jonathan Lowery Ph.D

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Symptom Report of Long-Stay Nursing Home Residents, Meaghan Mobley OMS-2; Luke Miller OMS-2; Kathleen Unroe MD, MHA; and Susan Hickman Ph.D

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Multi Drug Resistant Plasmid Transfer Between Salmonella and Two E. Coli Strains, Jane Pangburn OMS-2 and Samina Akbar Ph.D

How Much Will My Child’s Operation Cost? Availability of Consumer Prices from US Hospitals for a Common Pediatric Orthopaedic Surgical Procedure, Allison Racimo OMS-3; Nakul Talathi BS; Nicole Zelenski MD; Lawrence Wells MD; and Apurva S. Shan MD, MBA

Association and Impact of Hypertension Defined Using the 2017 AHA/ACC Guidelines on the Risk of Atrial Fibrillation in ARIC Cohort, Anas Rattani OMS-1, Alvaro Alonso, and Mohammed K. Ali

Ultrasound-guided Great Saphenous Vein Access in Trauma Cases, Jessica Roberts OMS-2, Nathan Roberts, Gaston Dana, and Necla Erdini

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Network Analysis of Skeletal Muscle During Spaceflight in Male Mice, Michael Savaglio OMS-2, Nabarun Chakraborty, Paul Childress, Raina Kumar, George Dimitrov, Bintu Sowe, Aarti Gautam, David Waning, Rasha Hammamieh, and Melissa Kacena

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Chemokine Profiling of Vaginal Epithelial Cells Exposed to Gardnerella Vaginalis, Betsy Schlehuser OMS-4, Oladipupo Ogunbekun OMS-1, Jonathan Lowery Ph.D, and Bryan Larsen Ph.D

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Osteocyte-Specific Deletion of the α2δ1 Auxiliary Voltage Sensitive Calcium Channel Subunit, Artur Schneider OMS-1, Christian S. Wright, Xin Yi, Julia M. Hum Ph.D, and William R. Thompson

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Bringing Attention to Lesser-known Bone Remodeling Pathways, Mehdi Shadmand OMS-2, Krista Jackson OMS-1, Cecelia Bender OMS-2, Stephen Donnelly OMS-4, Henry Guan OMS-4, Kirby Tobin OMS-2, Syndi Yates OMS-2, Julia Hum Ph.D, and Jonathan Lowery Ph.D

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Contribution of Lipid Droplet Breakdown to Coxiella Burnetii Infection, Rachel Silliman OMS-2, Stacey D. Gilk, and Minal Mulye Ph.D

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3D Visualization of Brainstem Anatomy in Relation to Lateral Medullary (Wallenberg) Syndrome, Ashley Starcevich OMS-2 and David Dufeau Ph.D

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Aesculapius: Adding a Dimension of Instruction Through Integrating Spatial Knowledge, Sergej Stjepic OMS-2, Bradley Boget OMS-2, David Dufeau Ph.D, and Garren Gebhardt D.O.

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Developing an In Vitro Model of CKD-MBD Induced αKlotho Suppression, Kirby Tobin OMS-2, Timothy Waite OMS-2, Forrest Oberhelman OMS-3, and Julia Hum Ph.D

Examining Sudden Cardiac Death in High School Competitive Athletes: An Overview of Contributing Etiologies, Prevalence, Screening, and Participation Guidelines, Cory Tom and Daniel Gelfman MD, FACP, FACC

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Antagonism Between Bone Morphogenetic Protein and Activin Signaling Pathways in Osteoprogenitor Cells, Madeline Totten, Sydni Yates OMS-2, Kelli Jestes, Sylvia Chlebek OMS-3, Jordan Newby, Jon Arthur, and Jonathan W. Lowery Ph.D

Effect of Scoliosis/Treatment on Pulmonary Function Relative to Stature in SMA, Michael Troy BS, OMS-1; Patricia Miller MS; Robert Graham MD; and Brian Snyder MD, Ph.D

Advancements in the Treatment of Opioid Abuse Disorder, Kendal Willcox; Kristen Metzler-Wilson PT, Ph.D; and Michael LaFontaine Ph.D

Paclitaxel Dose in iPSC-Generated Sensory Neurons for Ex Vivo Modeling of Taxane-Induced Peripheral Neuropathy, Rina Yadav OMS-4, Laura Gardner, Xi Wu, Geneva Cunningham, Fei Shen, and Bryan P. Schneider

Modification of Kynurenine Pathway via Inhibition of Kynurenine Hydroxylase Attenuates Surgical Brain Injury, George Zakhary OMS-2; Prativa Sherchan Ph.D; Qian Li Ph.D; Jiping Tang MD; and John H. Zhang MD, Ph.D

Submissions from 2017

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Towards Multi-Modality Therapy for Marfan Syndrome: Synergistic Effect of Angiotensin and TRPC4 Receptor Blockade on Ascending Aortic Aneurysms, Nicholas B. Cavanaugh; Lan Qian MBBS; Nicole M. Westergaard; and Joseph W. Turek MD, Ph.D.

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Elucidating the Antagonistic Relationship Between Bone Morphogenetic Protein and Activin Signaling Pathways in Osteoprogenitor Cells, Sylvia Chlebek, Jordan Newby, Jon Arthur, and Jonathan W. Lowery Ph.D.

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Activin and BMP Signaling Mechanics in Myogenic Cells, Tim Cho and Jonathan W. Lowery Ph.D.

The Basal Ganglia: Pathways and Movement Disorders, Hannah Christopher OMS-II and David Dufeau Ph.D.

Effect of Decreasing Peripheral Skin Blood Flow Via Local Axon Reflexes, Decreases in Perfusion Pressure, and Ischemia during Systemic Thermal-Induced Eccrine Sweating in Humans, James W. Daggett OMS-II; Kenan Alibegovic OMS-II; Milie M. Fang; Kristen Metzler-Wilson PT, Ph.D.; and Thad E. Wilson Ph.D.

Effect of Cutaneous Local Axon Reflexes, Perfusion Pressure, and Ischemia on Exogenous Cholinergic-Induced Eccrine Sweating in Humans, Milie M. Fang OMS-II; Uma S. Kocherlakota; Kenan Alibegovic OMS-II; James W. Daggett OMS-II; Seetharam C. Narra BMS-II; Thad E. Wilson Ph.D.; and Kristen Metzler-Wilson PT, Ph.D.

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Identification of Commercially Available Antibodies that Block Ligand Binding by BMPR2, Ruthann E. Gorrell, Laura Schoerning, Jordan Newby, Warren Lawless, Aaron M. Hudnall, Julia M. Hum, and Jonathan W. Lowery Ph.D.

Hexosamine Biosynthesis Pathway Is a Potential Link Between Insulin Resistance and Alzheimer’s Disease, Katherynne Greve, Mackenzie Powell, Brian Grice, Daniel Vigil, Stephen Boehm, Wei Lei, and Jeffrey Elmendorf

Examining LRP4’s Capacity to Participate in Inhibitory WNT Signaling in Bone Cells, Julia M. Hum, Madison Kelly, Mehdi Shadmand, Tyler Lucas, Curren Sharma, and Alexander G. Robling

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Identification of Gene Signature Associated with Elevated Bone Formation Rate in Aging Mice, Krista Jackson, Aaron M. Hudnall, and Jonathan W. Lowery Ph.D.

Model Online Educational Platform for Health Services, Ben Kopecky OMS-I

Outcomes in Blunt Cerebrovascular Injury Following the Use of an Evidence-Based Treatment Protocol, TJ Kovanda, ZA Freeman, AP Melillo, LE Jacobson, TJ Leipzig, DH Sahlein, and RB Rodgers

Sorbitol Protection Assay Provides Insight into Antifungal Mechanisms of Boron Compounds against Candida albicans and Candida Glabrata, Bryan Larsen Ph.D.

Metabolic Syndrome is Associated with an Increased Risk of 30-Day Morbidity and Mortality after Lower Extremity Bypass Surgery, Andrew Lehman MPH, OMS-I and Ying Wei Lum M.D., MPH

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Experience with and Perception of Research Among First Year Osteopathic Medical Students, Hinduja Nallamala, Conor Kirby OMS-I, Sarah Zahl, Kelly Kaneshiro, Victoria Nguyen, Glen Kisby, and Jonathan W. Lowery Ph.D.

Mice Lacking the a2d1 Auxiliary Voltage Sensitive Calcium Channel Subunit Have Impaired Bone Quantity and Decreased Lean Mass, Karan Sharma, Madison Kelly, Megan Noonan, Xin Yi, Alexander G. Robling, Julia M. Hum, and Mary C. Farach-Carson

Disambiguating the Effect of Interpolated Testing on the Build-up of Proactive Interference During Learning, Breyauna Spencer and Karl Szpunar

Short Duration Exposure of Vibrio Cholerae to Small Intestine Conditions and the Effect on Cholera Toxin and Stringent Response Gene Expression, Michael Stewart OMS-II and David Raskin

Investigating the HSF1-HSF2 Interaction, Bryan Wacker, Alex Jaeger, and Dennis Thiele Ph.D.

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Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption, Nicholas Weinstein, Michael S. Eaton, Stephen R. Shively, Hannah M Davis, Lillian Plotkin, and Jonathan W. Lowery Ph.D.

Employment of the Novel Laser Direct Alignment Radiation Reduction Technique (DARRT) for Percutaneous Nephrolithotomy Access, Patrick W. Yang, Samuel Abourbih M.D., Jim Shen M.D., Salim Cheriyan M.D., Mohamed Keheila M.D., Jason Smith M.D., and D. Duane Baldwin M.D.

Submissions from 2016

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Cryoglobulinemic Vasculitis in a Patient with Trismus Pseudocamptodactyly, Joseph Aleshaki OMS-III, Kurt Ashack, and Anthony Martin

Are Axon Reflex Responses Altered in Rosacea?, Jeffrey Stephen Blakesley OMSII; Patrick Clegg OMSII; Thad E. Wilson Ph.D.; and Kristen Metzler-Wilson PT, Ph.D.

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3D Methods for Medical Education and Clinical Practice, Molly Buynak OMSII; Leonard K. Song OMSII; and David Dufeau, PhD

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3D Visualization of Two Surgical Approaches for Correcting a Congenital Heart Defect, Mary Carrier OMSII

Abstract, Emily Dougherty OMSII

Loss of BMPR2 Expression in Skeletal Progenitor Cells Reduces Age-Related Bone Loss, Michael S. Eaton OMSIII

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Testing Novel Phenolic Fluorophores as Palladium Sensors at Different Concentrations, Max Gallivan, Christopher Shrack OMSI, and Laura Wysocki Ph.D.

Indirect vs. Direct Assessment of Cold Induced Vasodilation, Daniel Gerow OMSII, Patrick Clegg OMSII, and Thad E. Wilson Ph.D.

Abstract, Emma Hegwood OMSIV

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Doing Research Separated By Distance and Time With Blinded Duplication: Building an Epigenetic Database, Scott D. Hines OMSIII, Namita Biala OMSIII, Daniel R. Hutchinson OMSIII, Jacob Suazo, Sade Akinkuotu, and Sage Arbor Ph.D.

Abstract, Julia M. Hum

Safety and Efficacy of Fecal Microbiota Transplantation in Patients with a History of Solid Organ Transplant and C. Difficile Infection, Noor Khan OMSII and Monika Fischer M.D., MSCR

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Early Expression of D-Pax2 in Drosophila Sense Organs is Controlled by a 700 Base Pair Cis-Regulatory Region, Conor Kirby OMS-I and Joshua Kavaler

Student Use of Virtual Microscopy Laboratory Modules in an Integrated Medical Curriculum, Shirley Kotadia OMSI and Allison K. Chatterjee Ph.D.

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Identify cmy-2 Incompatibility Groups in Salmonella Multidrug Resistance Plasmids, Stephen M. Kuehn OMSII and Samina Akbar

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Characterizing The Patient Population With 30-Day Readmissions From COPD and Heart Failure, Nathan Lambert-Cheatham OMS-II

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Establishing Relevant ADC-based Texture Analysis Metrics for Quantifying Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinomas, Kelly Loman OMS-I, Jeff Nawrocki, Jenny Hoang, David Yoo, Zheng Chang, Yvonne Mowery, Xuechan Li, Bercedis Peterson, David Brizel, and Oana Craciunescu

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Assessing Readability of Online Patient Education Materials for Spine Surgery Procedures, William Long OMS-I, William W. Long BA1, Krishna D. Modi BS1, Dustin H. Massel BS1, Benjamin C. Mayo BA1, and Kern Singh MD1

Identification of Antimicrobial Resistance Genes and Plasmid Types in Isolates of Salmonella Enterica, Emily Martin OMSII

The Automated Discovery of Implied Causation Statements in Medical Research Literature: The Text-based Causation Signal "caused by", Hinduja Nallamala OMSI

Boric Acid and Persisters in Candida Albicans, Thomas Piotrowski OMSII and Bryan Larsen Ph.D.

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Stringent Response Regulation of Virulence Factors in Vibrio Cholera, David Raskin, Arunima Mishra, Huajun He, Swathi Mall, and Jennifer Cooper

Identification of Commercially-Available Antibodies that Block Ligand-Binding by BMPR2, Laura Schoerning OMSII, Ruthann E. Gorrell, Jordan B. Newby, Julia M. Hum, and Jonathan W. Lowery Ph.D.

Bone Grafting Technologies: Current and Prospective Therapies, Wililam Snyder OMSII

Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption, Taylor Ward OMSII

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3D Visualization of Cardiac Anatomy: New Approaches for Patient Education, Rachel Whitman OMS-II and David Dufeau Ph.D.

Submissions from 2015

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Comparison of Patient Tolerance of Photodynamic Therapy with Zone vs. Full Face Treatment, Joseph Aleshaki OMS-II and Dr. Kevin Crawford

Characterization of Spatio-Temporal Expression of Novel Hypoxia-Induced Genes in Zebrafish, Adam Amir OMSI and Farhad B. Imam M.D., Ph.D.

Elucidating the Antagonistic Relationship Between Bone Morphogenetic Proteins and Activins in the Skeleton, Jon Arthur OMSII and Jonathan W. Lowery Ph.D.

Mitigation of Stomach Dehiscence Risk During Gastrostomy Tube Changes – A Retrospective Analysis of Patient Outcomes, Ethan Charles Blocher-Smith OMSI

The Impact of Medically-Related Experiences on Spatial Ability: Instrument Creation, A. K. Chatterjee, C. Bonger, J. Braun, D. Daum, and A. Lee

Effects of Whole-Body Heating on Skin Blood Flowmotion in Rosacea, Emily Eaton; Kristen Metzler-Wilson PT, Ph.D.; Kumika Toma Ph.D.; Andrew Jurovcik OMS-IV; Dawn Sammons D.O.; and Thad E. Wilson Ph.D.

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Loss of BMPR2 Expression in Skeletal Progenitor Cells Reduces Age-Related Bone Loss, Michael S. Eaton, Jordan B. Newby, Aaron M. Hudnall, Vickie Rosen, and Jonathan W. Lowery Ph.D.

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Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption, Michael S. Eaton, Jordan B. Newby, Maggie Plattes, Hanna E. Foster, Eric M. Wauson, Brian J. Dewar, Jon Arthur OMSII, and Jonathan W. Lowery Ph.D.

Coding DNA into Music: An Alternate Way of Analysis, Sam Fesenmeier OMSI