Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

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Human Papilloma Virus (HPV)-Associated Oropharyngeal Cancer


Cancer Biology


HPV is the most common sexually transmitted infection and it is predicted that up to 80 % of Americans will have HPV infections in their lifetime (Centers for Disease Control and Prevention 2015). The etiology of cervical cancer has long been linked with persistent HPV infection, but the correlation between HPV and other cancer types, including head and neck squamous cell carcinomas (HNSCC), oropharyngeal carcinomas (OPCs), anal carcinomas, and cancers of the genital tract is emerging (Forman et al. 2012). Compared to alcohol- and tobacco-related HNSCC, HPV-associated head and neck cancer involves activation of specific molecular mechanisms, making HPV(+) HNSCCs diagnostically and therapeutically distinct. Here, we will review the current understanding of the molecular mechanisms in HPV(+) HNSCC with emphasis on the signaling events that drive the growth of HPV-associated HNSCC and the emerging opportunities for the development of novel precision molecular-targeted therapies for this disease.


Copyright All Authors; 2015 Springer International Publishing


Chapter 7 in Human Papilloma Virus (HPV)-Associated Oropharyngeal Cancer. Sharon Stack (ed.); 2015, Springer International Publishing. ISBN: 978-3-319-21100-8.