Title

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer.

Document Type

Article

Publication Date

1-2012

Published In / Presented At

Cell research

Disciplines

Cancer Biology

Abstract

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer. Angiogenesis is controlled by delicate balance between pro- and anti-angiogenic signals. While pro-angiogenic signaling has been extensively investigated, how developmentally regulated, naturally occurring anti-angiogenic molecules prevent the excessive growth of vascular and lymphatic vessels is still poorly understood. In this review, we summarize the current knowledge on how semaphorins and their receptors, plexins and neuropilins, control normal and pathological angiogenesis, with an emphasis on semaphorin-regulated anti-angiogenic signaling circuitries in vascular and lymphatic endothelial cells. This emerging body of information may afford the opportunity to develop novel anti-angiogenic therapeutic strategies.

Rights

Copyright all authors

Comments

Author, Doci CL, not affiliated with Marian University-Indianapolis at time of publication.

DOI

10.1038/cr.2011.198

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