Sympathoexcitation causes differing responses in supraorbital vs peripheral skin nerves: implications for rosacea Público Deposited
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MLA citation style. 2020. https://mushare.marian.edu/concern/generic_works/75d37f72-a59c-4b4e-9723-e597653f1714?locale=pt-BR Sympathoexcitation Causes Differing Responses In Supraorbital Vs Peripheral Skin Nerves: Implications for Rosacea.
APA citation style(2020). Sympathoexcitation causes differing responses in supraorbital vs peripheral skin nerves: implications for rosacea. https://mushare.marian.edu/concern/generic_works/75d37f72-a59c-4b4e-9723-e597653f1714?locale=pt-BR
Chicago citation styleSympathoexcitation Causes Differing Responses In Supraorbital Vs Peripheral Skin Nerves: Implications for Rosacea. 2020. https://mushare.marian.edu/concern/generic_works/75d37f72-a59c-4b4e-9723-e597653f1714?locale=pt-BR
Note: These citations are programmatically generated and may be incomplete.
Previous studies indicate that common fibular, tibial, and radial skin sympathetic nerve activity (SSNA) increases with physical stress in an exercise intensity-dependent manner but abates during ischemia when class Ill & IV muscle afferents are stimulated without the engagement of the motor cortex. It is currently unknown if these peripheral nerve responses are similar to nerves of the face. Rosacea, a fascial flushing disorder, results in substantially higher physical and mental stress-induced increases in SSNA, but it is unknown if this is modifiable. We hypothesize that physical stress increases supraorbital SSNA in an intensity-dependent manner. Furthermore, we hypothesize that post-exercise muscle ischemia (PEMI) will not modulate supraorbital SSNA Nine healthy subjects (5M/ 4F) participated in a series of physical stressors known to be symptom-triggering in individuals with rosacea. Forehead SSNA (supraorbital microneurography) was measured during handgrip exercise for 1 minute at 15%, 30%, and 45% of their maximum hand grip strength. Additionally, 2 minutes of hand grip at 30% of maximum, followed by 2 minutes of PEMI (upper-arm arterial occlusion) were completed to assess the role of muscle afferents in the SSNA response. Skin blood fiow (laser-Doppler fiowmetry) and transepithelial water loss/sweat rate (TEWUSR; capacitance hygrometry) were measured on both the forehead and the ventral forearm during procedures. Heart rate (HR; ECG) and mean arterial pressure (MAP; finger photoplethysmography) were also recorded. All intensities of handgrip increased HR and MAP, and these responses were positivity correlated with intensity. Handgrip also increased SSNA, but there was no association with intensity. No changes in skin blood fiow or TEWUSR were observed across trials. PEMI maintained handgrip-induced elevations of MAP and SSNA, albeit at a reduced magnitude compared to baseline. Contrary to our hypothesis, physical stress did not increase supraorbital SSNA in an intensity-dependent manner (15%, 30%, and 45% of maximum handgrip strength). Furthermore, unlike peripheral SSNA which increases during physical stress but abates during PEMI , these data indicate that ischemia or ischemic pain increases supraorbital SSNA These data imply that supraorbital SSNA differs in control and regulation from peripheral nerves, and these differences could potentially account for altered supraorbital SSNA results observed in individuals with rosacea.