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Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Public Deposited

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Gutkind, J. Silvio, Doci, Colleen L, and Sakurai, Atsuko. Semaphorin Signaling In Angiogenesis, Lymphangiogenesis and Cancer. Nature Publishing Group. 2012. https://mushare.marian.edu/concern/generic_works/6bc7367b-80af-4656-8710-29cde66be2a9

APA citation style

Gutkind, J. Silvio, Doci, Colleen L, & Sakurai, Atsuko. (2012). Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. https://mushare.marian.edu/concern/generic_works/6bc7367b-80af-4656-8710-29cde66be2a9

Chicago citation style

Gutkind, J. Silvio, Doci, Colleen L., and Sakurai, Atsuko. Semaphorin Signaling In Angiogenesis, Lymphangiogenesis and Cancer. Nature Publishing Group. 2012. https://mushare.marian.edu/concern/generic_works/6bc7367b-80af-4656-8710-29cde66be2a9

Note: These citations are programmatically generated and may be incomplete.

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer. Angiogenesis is controlled by delicate balance between pro- and anti-angiogenic signals. While pro-angiogenic signaling has been extensively investigated, how developmentally regulated, naturally occurring anti-angiogenic molecules prevent the excessive growth of vascular and lymphatic vessels is still poorly understood. In this review, we summarize the current knowledge on how semaphorins and their receptors, plexins and neuropilins, control normal and pathological angiogenesis, with an emphasis on semaphorin-regulated anti-angiogenic signaling circuitries in vascular and lymphatic endothelial cells. This emerging body of information may afford the opportunity to develop novel anti-angiogenic therapeutic strategies.

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  • fp_db13
  • Cell research (Vol.22, Iss.1)
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