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The Role of CaMKK2 in Whole-Body Metabolism and Bone Remodeling Public Deposited

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Sankar, Uma, Patel, Sheel, and Williams, Justin. The Role of Camkk2 In Whole-body Metabolism and Bone Remodeling. . 2021. https://mushare.marian.edu/concern/generic_works/5b12da98-991f-49fd-b76f-9a911dde7cdc?locale=en

APA citation style

Sankar, Uma, Patel, Sheel, & Williams, Justin. (2021). The Role of CaMKK2 in Whole-Body Metabolism and Bone Remodeling. https://mushare.marian.edu/concern/generic_works/5b12da98-991f-49fd-b76f-9a911dde7cdc?locale=en

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Sankar, Uma, Patel, Sheel, and Williams, Justin. The Role of Camkk2 In Whole-Body Metabolism and Bone Remodeling. 2021. https://mushare.marian.edu/concern/generic_works/5b12da98-991f-49fd-b76f-9a911dde7cdc?locale=en

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Obesity and metabolic dysfunction negatively impacts many tissues, including the skeleton. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase and key regulator of whole-body energy homeostasis. Previous studies have shown that male Camkk2-/- mice are protected from high-fat diet induced obesity, glucose intolerance and insulin resistance. CaMKK2 regulates hypothalamic control of appetite, hepatic gluconeogenesis, and insulin production by pancreatic β cells. Deletion of CaMKK2 has also been shown to enhance bone mass and strength in mice. The skeleton is recognized as a highly dynamic and metabolic tissue capable of regulating systemic glucose metabolism. The role of CaMKK2 in bone-mediate regulation of whole-body metabolism is unknown.

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