Generic Work

 

Bringing Attention to Lesser-known Bone Remodeling Pathways Publique Deposited

Contenu téléchargeable

Télécharger le PDF

MLA citation style

Tobin, Kirby OMS-2, et al. Bringing Attention to Lesser-known Bone Remodeling Pathways. . 9120. https://mushare.marian.edu/concern/generic_works/4f497032-1e5b-4cd7-82ae-1574e04ee947?locale=fr

APA citation style

Tobin, Kirby OMS-2, Lowery, Jonathan W, Donnelly, Stephen OMS-4, Shadmand, Mehdi OMS-2, Bender, Cecelia OMS-2, Jackson, Krista OMS-1, Hum, Julia, Yates, Sydni OMS-2, & Guan, Henry OMS-4. (9120). Bringing Attention to Lesser-known Bone Remodeling Pathways. https://mushare.marian.edu/concern/generic_works/4f497032-1e5b-4cd7-82ae-1574e04ee947?locale=fr

Chicago citation style

Tobin, Kirby OMS-2, Lowery, Jonathan W., Donnelly, Stephen OMS-4, Shadmand, Mehdi OMS-2, Bender, Cecelia OMS-2, Jackson, Krista OMS-1, Hum, Julia et al. Bringing Attention to Lesser-Known Bone Remodeling Pathways. 9120. https://mushare.marian.edu/concern/generic_works/4f497032-1e5b-4cd7-82ae-1574e04ee947?locale=fr

Note: These citations are programmatically generated and may be incomplete.

Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer and, by 2025, the number of fractures due to osteoporosis is expected to rise to nearly three million in the USA alone. Pharmacological treatments for osteoporosis are aimed at stabilizing or increasing bone mass. However, there are significant drawbacks to current pharmacological options, particularly for long-term management of this chronic condition. Moreover, the drug development pipeline is relatively bereft of new strategies. Consequently, there is an urgent and unmet need for developing new strategies and targets for treating osteoporosis. Casual observation led us to hypothesize that much of the bone remodeling research literature focused on relatively few molecular pathways. This led us to perform bibliometric analyses to determine the relative popularity of bone remodeling pathways in publications and US National Institutes of Health funding of the last 10 years. In this review article, we discuss these findings and highlight several less-examined signaling pathways that may hold promise for future therapies.

Creator
Language
Identifier
Mot-clé
Date created
Related URL
Resource type
Source
  • Clinical Reviews in Bone and Mineral Metabolism
  • com_fp_38
Rights statement

Relationships

Dans Collection:

Articles