The Role of GM-CSF in the Neuropathogenesis of Simian Immunodeficiency Virus (SIV)
上市 DepositedMLA citation style (9th ed.)
The Role of Gm-csf In the Neuropathogenesis of Simian Immunodeficiency Virus (siv). . 2021. mushare.marian.edu/concern/generic_works/46f6de71-7516-45a3-9598-208ad22fabd6?locale=zh.APA citation style (7th ed.)
(2021). The Role of GM-CSF in the Neuropathogenesis of Simian Immunodeficiency Virus (SIV). https://mushare.marian.edu/concern/generic_works/46f6de71-7516-45a3-9598-208ad22fabd6?locale=zhChicago citation style (CMOS 17, author-date)
The Role of Gm-Csf In the Neuropathogenesis of Simian Immunodeficiency Virus (siv). 2021. https://mushare.marian.edu/concern/generic_works/46f6de71-7516-45a3-9598-208ad22fabd6?locale=zh.Note: These citations are programmatically generated and may be incomplete.
Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy
(cART)?
• The brain is a known reservoir for HIV.
• HIV can act on myeloid cell populations like macrophages.
• Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a hematopoietic growth factor and type I
soluble cytokine that has been demonstrated to have a proinflammatory role over macrophages (and other
myeloid cells) and can induce proliferation and migration across the blood brain barrier (Vogel 2015).
• GM-CSF has also been found to be present and is involved in the inflammation process of Simian
Immunodeficiency Virus (SIV).
• Along with GM-CSF, the expression of GM-CSF receptors has been shown to be increased in SIV.
Hypothesis: In SIV infected regions of the midbrain, GM-CSF expression will be increased, which would
contribute to the HIV neuropathogenesis by attracting inflammatory cells such as macrophages.
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