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The Role of GM-CSF in the Neuropathogenesis of Simian Immunodeficiency Virus (SIV) Public Deposited

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Meckley, Rachael, and Delery, Elizabeth. The Role of Gm-csf In the Neuropathogenesis of Simian Immunodeficiency Virus (siv). . 2021. https://mushare.marian.edu/concern/generic_works/46f6de71-7516-45a3-9598-208ad22fabd6?locale=en

APA citation style

Meckley, Rachael, & Delery, Elizabeth. (2021). The Role of GM-CSF in the Neuropathogenesis of Simian Immunodeficiency Virus (SIV). https://mushare.marian.edu/concern/generic_works/46f6de71-7516-45a3-9598-208ad22fabd6?locale=en

Chicago citation style

Meckley, Rachael, and Delery, Elizabeth. The Role of Gm-Csf In the Neuropathogenesis of Simian Immunodeficiency Virus (siv). 2021. https://mushare.marian.edu/concern/generic_works/46f6de71-7516-45a3-9598-208ad22fabd6?locale=en

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Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy (cART)? • The brain is a known reservoir for HIV. • HIV can act on myeloid cell populations like macrophages. • Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a hematopoietic growth factor and type I soluble cytokine that has been demonstrated to have a proinflammatory role over macrophages (and other myeloid cells) and can induce proliferation and migration across the blood brain barrier (Vogel 2015). • GM-CSF has also been found to be present and is involved in the inflammation process of Simian Immunodeficiency Virus (SIV). • Along with GM-CSF, the expression of GM-CSF receptors has been shown to be increased in SIV. Hypothesis: In SIV infected regions of the midbrain, GM-CSF expression will be increased, which would contribute to the HIV neuropathogenesis by attracting inflammatory cells such as macrophages.

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