Work

Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD

Publique Deposited

MLA citation style (9th ed.)

Liesen, Michael P, et al. Segregating the Effects of Ferric Citrate-mediated Iron Utilization and Fgf23 In a Mouse Model of Ckd. The Physiological Society. 2022. mushare.marian.edu/concern/generic_works/445997ef-6eb3-42ea-a3da-d51c1db83d9e?locale=fr.

APA citation style (7th ed.)

L. M. P, A. R, S. E, N. M, N. P, D. J, W. J, C. E, A. M, W. K., & H. Julia. (2022). Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD. https://mushare.marian.edu/concern/generic_works/445997ef-6eb3-42ea-a3da-d51c1db83d9e?locale=fr

Chicago citation style (CMOS 17, author-date)

Liesen, Michael P., Agoro, R., Swallow, E., Noonan, M., Ni, P., Damrath, J., Wallace, J. et al. Segregating the Effects of Ferric Citrate-Mediated Iron Utilization and Fgf23 In a Mouse Model of Ckd. The Physiological Society. 2022. https://mushare.marian.edu/concern/generic_works/445997ef-6eb3-42ea-a3da-d51c1db83d9e?locale=fr.

Note: These citations are programmatically generated and may be incomplete.

Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) pa-
tients as a phosphate (Pi) binder for dialysis-dependent CKD, and for iron de-
ficiency anemia (IDA) in non-dialysis CKD. Elevated Pi and IDA both lead to
increased FGF23, however, the roles of iron and FGF23 during CKD remain un-
clear. To this end, iron and Pi metabolism were tested in a mouse model of CKD
(0.2% adenine) ± 0.5% FC for 6 weeks, with and without osteocyte deletion of
Fgf23 (flox-Fgf23/Dmp1-Cre). Intact FGF23 (iFGF23) increased in all CKD mice
but was lower in Cre+ mice with or without FC, thus the Dmp1-Cre effectively
reduced FGF23. Cre+ mice fed AD- only had higher serum Pi than Cre− pre- and
post- diet, and the Cre+ mice had higher BUN regardless of FC treatment. Total
serum iron was higher in all mice receiving FC, and liver Tfrc, Bmp6, and hepci-
din mRNAs were increased regardless of genotype; liver IL- 6 showed decreased
mRNA in FC- fed mice. The renal 1,25-dihydroxyvitamin D (1,25D) anabolic
enzyme Cyp27b1 had higher mRNA and the catabolic Cyp24a1 showed lower
mRNA in FC- fed mice. Finally, mice with loss of FGF23 had higher bone corti-
cal porosity, whereas Raman spectroscopy showed no changes in matrix mineral
parameters. Thus, FC- and FGF23-dependent and - independent actions were
identified in CKD; loss of FGF23 was associated with higher serum Pi and BUN,
demonstrating that FGF23 was protective of mineral metabolism. In contrast, FC
maintained serum iron and corrected inflammation mediators, potentially pro-
viding ancillary benefit.

Creator
Publisher
Language
Identifier
Mot-clé
Date created
Related URL
Resource type
Source
  • Physiological Reports (Vol.10, no.11)

Rights statement

Contenu