Generic Work

 

Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health Public Deposited

Downloadable Content

Download PDF

MLA citation style

Yar, Neela, Larsen, Bryan, and Whitman, Emma OMS-2. Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health. . 8120. https://mushare.marian.edu/concern/generic_works/3aee0e19-9f40-4610-b804-621a107ff083?locale=en

APA citation style

Yar, Neela, Larsen, Bryan, & Whitman, Emma OMS-2. (8120). Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health. https://mushare.marian.edu/concern/generic_works/3aee0e19-9f40-4610-b804-621a107ff083?locale=en

Chicago citation style

Yar, Neela, Larsen, Bryan, and Whitman, Emma OMS-2. Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health. 8120. https://mushare.marian.edu/concern/generic_works/3aee0e19-9f40-4610-b804-621a107ff083?locale=en

Note: These citations are programmatically generated and may be incomplete.

This paper explores one of the underappreciated reasons for lack of efficacy in certain cases of antimicrobial therapy, namely the occurrence of a non-genetic resistance to antimicrobial drugs due to a metabolic quiescence of microorganisms. This review has centered on those microorganisms of particular importance in obstetrics and gynecology and accordingly has reviewed the nature and extent of the persister phenotype in relation to infectious agents affecting women’s health. We show how the quiescent persister microbial phenotype represents the next significant issue that could compromise successful antibiotic therapy. A brief history of antimicrobial therapy is provided as context for the problem posed by the persister phenotype. This review has been focused on the current literature having relevance for physicians concerned with women’s health. The study of this phenotype has led to increasing understanding of the molecular mechanisms for this state which also provides ideas for rational development of drug candidates to interdict these organisms in human disease and explores the possibility of developing specifically targeted molecules to address persisters, research on screening botanicals, existing drugs and chemicals to discover novel approaches to the clinical consequence of microbial persisters. Of interest in this review, is the return to naturally occurring botanical substances, first to be used as anti-infectives, now being considered as possible agents to address persister microorganisms. Overall this paper aims to provide information tailored especially to the obstetrics and gynecology specialists.

Creator
Language
Identifier
Keyword
Date created
Resource type
Source
  • mucom_spr_31
  • Open Journal of Obstetrics and Gynecology
Rights statement

Relationships

In Collection:

Items