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Notum: A Novel Regulator of Bone and Its Implications in Osteoporosis Public Deposited

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MLA citation style

Castanon, Mariah, et al. Notum: A Novel Regulator of Bone and Its Implications In Osteoporosis. . 2020. https://mushare.marian.edu/concern/generic_works/2cc835c5-343a-4088-a200-57b0682b45dd

APA citation style

Castanon, Mariah, Marshall, Vince, Wacker, Bryan, & Hum, Julia. (2020). Notum: A Novel Regulator of Bone and Its Implications in Osteoporosis. https://mushare.marian.edu/concern/generic_works/2cc835c5-343a-4088-a200-57b0682b45dd

Chicago citation style

Castanon, Mariah, Marshall, Vince, Wacker, Bryan, and Hum, Julia. Notum: A Novel Regulator of Bone and Its Implications In Osteoporosis. 2020. https://mushare.marian.edu/concern/generic_works/2cc835c5-343a-4088-a200-57b0682b45dd

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Osteoporosis is a silent, dangerous pathology frequently undiagnosed until patients experience a major fracture. About 1 in 2 women and 1 in 4 men ages 50 and above will experience bone fractures due to osteoporosis. Fractures from osteoporosis may lead to a 20% increase in mortality. Notum is a lipase, primarily expressed in the liver, that inhibits the Wnt signaling pathway. The Wnt pathway is involved in growth, development, and healing. Recently, inhibition or absence of Notum led to increased endocortical bone formation and thickness via osteoblast activity in a mouse model. Potentially, modifying factors that affect Notum expression could promote anabolic bone growth.

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