Muscle-derived factors influencing bone metabolism Público Deposited
Conteúdo disponível para downloadbaixar PDF
MLA citation styleElsevier. 2022. https://mushare.marian.edu/concern/generic_works/1799ece6-2e8f-4aa4-b5d9-87a7f2e326e3?locale=pt-BR Muscle-derived Factors Influencing Bone Metabolism.
APA citation style(2022). Muscle-derived factors influencing bone metabolism. https://mushare.marian.edu/concern/generic_works/1799ece6-2e8f-4aa4-b5d9-87a7f2e326e3?locale=pt-BR
Chicago citation styleMuscle-Derived Factors Influencing Bone Metabolism. Elsevier. 2022. https://mushare.marian.edu/concern/generic_works/1799ece6-2e8f-4aa4-b5d9-87a7f2e326e3?locale=pt-BR
Note: These citations are programmatically generated and may be incomplete.
A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated by a given stimulus, such as exercise, aging, and inactivity. Moreover, emerging evidence indicates that bone is heavily influenced by soluble factors derived from skeletal muscle (i.e., muscle-to-bone communication). The purpose of this review is to discuss the regulation of bone remodeling (formation and/or resorption) through skeletal muscle-derived cytokines (hereafter myokines) including the anti-inflammatory cytokine METRNL and pro-inflammatory cytokines (e.g., TNF-α, IL-6, FGF-2 and others). Our goal is to highlight possible therapeutic opportunities to improve muscle and bone health in aging.
- Date created
- Related URL
- Resource type
- Seminars in Cell and Developmental Biology (Vol.123)
- Rights statement