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Dose-dependent Response to Insulin and Bitter Melon Extract in MCF7 Cells Cultured in Low/Normal Glucose Público Deposited

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MLA citation style

Bhetwal, Bhupal Ph.D , and Kakuturu, Abhinav. Dose-dependent Response to Insulin and Bitter Melon Extract In Mcf7 Cells Cultured In Low/normal Glucose. . 2021. https://mushare.marian.edu/concern/generic_works/098619fc-838d-4df8-9abd-afd260708c0b?locale=pt-BR

APA citation style

Bhetwal, Bhupal Ph.D, & Kakuturu, Abhinav. (2021). Dose-dependent Response to Insulin and Bitter Melon Extract in MCF7 Cells Cultured in Low/Normal Glucose. https://mushare.marian.edu/concern/generic_works/098619fc-838d-4df8-9abd-afd260708c0b?locale=pt-BR

Chicago citation style

Bhetwal, Bhupal Ph.D , and Kakuturu, Abhinav. Dose-Dependent Response to Insulin and Bitter Melon Extract In Mcf7 Cells Cultured In Low/normal Glucose. 2021. https://mushare.marian.edu/concern/generic_works/098619fc-838d-4df8-9abd-afd260708c0b?locale=pt-BR

Note: These citations are programmatically generated and may be incomplete.

Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. Due to the high metabolic rate of cancer cells, we hypothesized that low glucose levels are detrimental to cell survivability and that BME exerts a cytotoxic effect by altering the capability of a cell to utilize glucose. Through this study, we seek to investigate if insulin is capable of mitigating the cytotoxic effects of BME and provide a “rescue effect” that increases cell viability, or even completely reverses the cytotoxic effects of BME.

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