Title

Bone Morphogenetic Protein-Based Therapeutic Approaches.

Document Type

Article

Publication Date

4-7-2017

Published In / Presented At

Cold Spring Harb Perspect Biol

Abstract

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-β family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate regulation of BMP signaling is critical for the development and homeostasis of numerous human organ systems. Aberrations in BMP pathways or their regulation are increasingly associated with diverse human pathologies, and there is an urgent and growing need to develop effective approaches to modulate BMP signaling in the clinic. In this review, we provide a wide perspective on diseases and/or conditions associated with dysregulated BMP signal transduction, outline the current strategies available to modulate BMP pathways, highlight emerging second-generation technologies, and postulate prospective avenues for future investigation.

Rights

Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved

DOI

10.1101/cshperspect.a022327