Vibrio cholerae is a Gram-negative bacterium that is the cause of the diarrheal disease cholera. Many strains have developed antibiotic resistance which allows these mutated strains to elude traditional treatment. Among the...
Introduction: Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. The PKC and ROK play critical roles in cell division, migration, and survival. However, the roles of protein kinase-c (PKC)...
Peroxisome proliferator-activated receptors (PPARs) are important nuclear receptors in regulating macrophage lipid metabolism and modulating cellular inflammatory responses. In recent years, host cell PPARs have been linked to...
Osteoporosis is a silent, dangerous, pathology frequently undiagnosed until patients experience a major fracture. Fractures from osteoporosis lead to a 20% increase of mortality, revealing a need for novel anabolic therapies....
Coxiella burnetii is an obligate intracellular bacterial pathogen and causative agent of Q fever. Chronic Q-fever manifests as potentially fatal endocarditis weeks to years after initial infection, suggesting Coxiella’s ability...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. They are surrounded by a phospholipid monolayer and store excess cellular free fatty...
Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy
(cART)?
• The brain is a known reservoir for HIV.
• HIV can act on myeloid cell populations like...
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While Coxiella initially infects alveolar macrophages, it may disseminate and cause endocarditis up to 20...
Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage diagnoses...
•Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. •HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage...
Obesity and metabolic dysfunction negatively impacts many tissues, including the skeleton. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase and key regulator of whole-body...
There is a need for anabolic therapies to treat degenerative bone
diseases. Mechanical loading stimulates anabolic and inhibits
catabolic pathways of bone leading to increased bone formation.
Osteocytes are the bone cell...
Bradykinin, a local dermal kallikrein-kinin system product, increases skin blood flow via a cyclic GMP mechanism but is not the active cutaneous vasodilation molecule associated with cholinergic stimulation. However, the...
While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
Coxiella burnetii is an obligate intracellular bacterium responsible for causing culture negative endocarditis. The manifestation of this condition several years following initial infection exhibits Coxiella’s ability to...
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. While significant advances in the...
In his book, Music Education in an Age of Virtuality and Post-Truth, Woodford presents a welcomed discussion of the aims of music education in a time of political unrest. This timely text is needed due to the stresses of the...
COVID-19 was primarily identified as a respiratory illness, but reports of patients presenting initially with cardiovascular complaints are rapidly emerging. Many patients also develop cardiovascular complications during and...
Background and Review of Literature: Caesarean sections are one of the most performed procedures in the operating room. Managing pain for these patients is vital to ensure a positive birthing experience for mothers and...
Background and Review of Literature: Postoperative nausea and vomiting (PONV) frequently occur in patients after anesthesia, significantly impacting patient satisfaction and potentially leading to untoward complications....
Community Health Needs Assessments and the developed strategies corresponding to any findings provide opportunities to improve the health of communities by targeted, coordinated efforts to meet the community needs. Thomas...
In 1984, Ultrasound-Guided (USG) Intravenous (IV) access was first used to place central venous catheters (CVC) in real-time. This led to increased success rates, reduced procedural times, decreased site associated...
Practitioners of course-based undergraduate research experiences (CUREs) often evaluate student learning through journal article style lab reports. In our biology department, CUREs are used in multiple required and elective...
Religion Matters: How Sociology Helps Us Understand Religion in Our World focuses on religion’s interplay with broader society, introducing students to the basic questions, ideas, and methods with which sociologists have...
Introduction Delayed vasopressor initiation can occur with septic patients who arrive to the emergency department (ED) hemodynamically stable but decompensate later in their ED or hospital course. The relationship between...
Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and...
Background: The lack of palliative care (PC) services poses a significant risk for PC patients. Research indicates that patients' needs often go unmet when PC referral processes are not well established within a health system....
In the intraoperative setting, the intersection of hand hygiene practices and contamination of the anesthesia workstation presents a critical juncture for reducing hospital acquired infections that ultimately lead to increased...
This article presents seven points of focused dissonance between Jeremiah and Romans, by identifying how Romans 9–11 inverts the judgment language of Jeremiah 1–20 against Judah. Without claiming that the inversions in Romans...
Exploring the intersection between Chicago's eight-hour movement and Protestant religious culture over a fifty-year span, this project considers how workers and clergy contested the religious meaning of the eight-hour system...
We argue that one of the best ways to improve equity and diversity in the plant sciences begins in the undergraduate
classroom. Our classrooms are the first stop for the next generation of plant scientists, and we must engage...
This article discusses the collaborative digitization effort between librarians at Marian College (now Marian University) and Indiana University Purdue University Indianapolis (IUPUI) to create a deliverable online collection...
Presented in the Active/Collaborative Learning track. and Student engagement and collaborative learning is enhanced by following the customized Internship Playbook. A large population of the students in the School of Business...
Over 1.25 million people reside in nursing facilities in the United States. Nursing facilities have reported 268,707 confirmed cases of COVID-19 and 61,765 COVID-19 deaths as of the week of November 2, 2020. Indiana was one of...
Recent studies describe racial and socioeconomic
(SES) disparities with mechanical thrombectomy
(MT) for acute ischemic stroke (AIS). Our study
investigated whether such disparities are present at
our institution and...
Healthcare disparities among different racial and ethnic groups are prevalent across the United States and worldwide. Healthcare provision may differ among racial and ethnic minorities, socioeconomic statuses, and insurance...
This article is an invitation to Christian youth and young adult educators and ministers to be more understanding of queer theology and to discern its place within ministry to and for young people. The article examines the term...
The LGBT+ community is generally grouped into one big group with all the same needs by media, organizations, and people. However, LGBT+ people have different concerns and needs based on age, race, ability, and so many other...
Background: Many surgical procedures require muscle paralysis of the patient to ensure optimum operating conditions. Monitoring the level of paralysis is an important responsibility of the nurse anesthetist throughout...