In this Interview Sr. Claire Whalen describes her early spirit of independence in Cincinnati OH, leading her toward an affinity for women leadership, and eventually her vocation at Oldenburg. She describes her role as an...
In her oral history Sr. Carol Ann Mause describes her family upbringing in Cincinnati, OH, her Catholic schooling as well as her internal struggle in deciding to enter religious life at Oldenburg, Indiana. She goes on to detail...
In this segment Sr. Barbara Piller reflects on the great influence of family on her vocation, leading to sixty-five years in religious life at the time of recording. She describes the spirit of independence as one of her gifts,...
In her oral history, Sr. Rose Marie McCann describes what it means to "have left the world" upon entering religious life in 1951. She details various circumstances of her eventual entrance to the convent at Oldenburg, namely...
In her oral history Sr. Rachel Lindenmaier reflects on her upbringing in Indianapolis and the appeal of the Franciscans who helped in her deciding to enter religious life. Also, she describes joining religious service alongside...
In her oral history, Sr. Madonna Bishop discusses her life as a Sister of Saint Francis, having a unique background as both a school teacher and a licensed practical nurse (LPN). Initially reluctant to enter the religious life,...
In this segment Sr. Evelyn Lindenmaier reflects on her decision to follow her twin sister, Rachel Lindenmaier, and her aunt, Sr. Leona, into the convent of the Sisters of Saint Francis, Oldenburg. Sr. Evelyn discusses her love...
In this segment, Sr. Cleopha Werner discusses God's presence in her life as exemplified by her relationships with her family. Sr. Cleo relates how her sister's faith was strengthened through hardships in her life and even up...
In her oral history, Sister Angela Betsch reflects on her experience growing up in White Oak, Cincinnati and her path to becoming a Sister of Saint Francis, Oldenburg. Sr. Angela highlights her decision to follow her older...
When the Sisters of St. Francis of Oldenburg founded Marian College in Indianapolis in 1937, they realized their vision of a rigorous, exemplary liberal arts education for women focused on empowering its students to effect...
BACKGROUND AND LITERATURE REVIEW: Hand hygiene (HH) is the number one way to reduce healthcare associated infections (HAI). These infections account for increased morbidity and mortality and are linked with poor HH among...
Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the AMA and NIH, spine fusion articles should be between a 4th and 6th...
Cancer cells have shown to exhibit enhanced potential to metastasize via increased actin-myosin crossbridge formation, which requires increased Ca2+ influx via the voltage-gated calcium channels. This then leads to the...
Traditional medical education has recently seen major changes due to the coronavirus (COVID-19) pandemic. New pedagogical methods, including augmented reality (AR) and virtual reality (VR), are on the rise as alternatives to...
The unique conditions of microgravity and radiation exposure in space have a substantial impact on human tissue function, resulting in extreme bone loss. The goal of this project is to synthesize the current knowledge on bone...
•Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. •HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage...
Interprofessional education or IPE involves bringing individuals from two or more professions together to learn and communicate to improve future teamwork and collaboration. IPE research has shown that exposing future...
The United States spends well over $100 billion for millions of people affected by Alzheimer’s disease and related dementias (ADRD) and for their family caregivers. Most people with ADRD have multiple chronic comorbid...
The DNA dependent protein kinase (DNA-PK) is a validated target for cancer therapeutics that drives the DNA damage response (DDR) and plays a critical role as a primary sensor in the non-homologous end joining (NHEJ) DNA double...
Paraspinal inhibition is an osteopathic manipulative treatment (OMT) purported to work via the sympathetic nervous system and aid in restoring autonomic homeostasis. Despite clinical anecdotal evidence, the mechanism of action...
Introduction: Externally added survival/growth factors are essential for the survival of healthy cells, however cancer cells are believed to be self-sufficient in supporting their auto-proliferation without the need of...
Osteocyte (Ot)-derived Sclerostin (Scl) has local actions in bone mediated by Lrp 4/5/6 receptors, inhibiting bone formation and stimulating bone resorption by antagonizing Wnt signaling. Emerging evidence suggests that Scl...
Introduction: It is well documented in the literature that Bitter Melon Extract (BME) inhibits the growth and proliferation of MCF-7 breast cancer cells. While the exact mechanism of this inhibition is unknown, it is possible...
Context: Skeletal muscle is essential for proper bodily functions by playing key roles in strength and movement, and it accounts for roughly 50% of our total body mass. Decreases in total muscle mass or mass-specific function...
Introduction: The Catholic medical ethic is supported by a rich intellectual tradition and remains foundational to the practice of medicine, especially within Catholic hospitals. In the US, the United States Conference of...
Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes Q fever in humans. While acute infection manifests as self-limiting flu-like illness, chronic Q fever presents as non-culturable endocarditis,...
A historical analysis and comparison between rubella and zika reveals that neither virus became prominent until their respective congenital syndromes were classified. Rubella was first described in the 1750s but took until 1941...
Sarcopenia is a disease characterized by degeneration of muscle and strength that puts individuals at increased risk of functional impairment, physical disability, and mortality. The risk of disability is 1.5 to 4.6 times...
Postpartum preeclampsia refers to hypertension and proteinuria after delivery, and the occurrence of a seizure within six weeks after delivery is called postpartum eclampsia. Etiology is unknown but theorized to involve...
300 targets using very small quantities of protein. This revealed decreased activation of the mTOR pathway in tibiae of Nmu knock-out mice compared to controls, with reduced activity-associated phosphorylation of mTOR and the...
Peroxisome proliferator-activated receptors (PPARs) are important nuclear receptors in regulating macrophage lipid metabolism and modulating cellular inflammatory responses. In recent years, host cell PPARs have been linked to...
Introduction: OPTIMISTIC is a project funded by the Centers for Medicaid and Medicare Services (CMS) that is aimed, in part, at the reduction of unnecessary hospitalization of nursing facility residents. Data from the initial...
Osteoporosis is a silent, dangerous, pathology frequently undiagnosed until patients experience a major fracture. Fractures from osteoporosis lead to a 20% increase of mortality, revealing a need for novel anabolic therapies....
INTRODUCTION: Cold limb immersion, a form of cryotherapy, can cause cardiovascu-lar changes due to cold-pain induced autonomic reflex. OBJECTIVE: This cryotherapy treatment side-effect has received less attention, and could...
Candida albicans and Candida glabrata, are two clinically relevant strains of yeast. They make up a majority of commonly seen pathologies such as vaginal yeast infections, nosocomial infections, and infections of...
Introduction: The adenine diet is widely used in animal models to produce a tubu-lointerstitial fibrosis and inflammation that mimics human CKD in many aspects. These include the biochemical manifestations hyperphosphatemia and...
Vibrio cholerae is a Gram-negative bacterium that is the cause of the diarrheal disease cholera. Many strains have developed antibiotic resistance which allows these mutated strains to elude traditional treatment. Among the...
Coxiella burnetii is an obligate intracellular bacterium responsible for causing culture negative endocarditis. The manifestation of this condition several years following initial infection exhibits Coxiella’s ability to...
Troglitazone (TRO), a peroxisome proliferator-activated receptor (PPAR) agonist, was a drug used as an anti-inflammatory and anti-diabetic agent. We had previously investigated a PPAR agonist that induced apoptosis in dose...
Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common cancers in the world, and even in developed countries like the United States, the five-year survival is only 65%. This already low survival rate drops...
Context 3-Dimensional (3D) imaging is utilized in a variety of ways in medicine, including ultra-sound facial scanning in utero, breast cancer detection, and mapping blood vessels. 3D imaging can also be used to educate both...
The work of children is school; despite this, medical providers and educators often live completely separately in their child-family interactions from one another. Yet, medical issues impact school success and school issues are...
A positive association between beta-carotene (BC)-rich food intake and a reduction in metabolic disorder incidence, including heart disease, is prevalent in humans. Similarly, preclinical research finds dietary BC...
Phosphorus equilibrium in the body is regulated through uptake and release via the intestine, kidney and bone. These processes are coordinated through the activity and regulation of Fibroblast Growth Factor 23 (FGF23). FGF23 is...
Hyperglycemic clamps are used as a gold standard measurement of beta cell function, allowing for measurement of a biphasic insulin response. Under this technique, the plasma glucose concentration is raised to a target...
70% at 2 weeks post-surgery (p>0.05). Stimulus- independent pain behavior was also evident in both vehicle and BMP-2 treated CSD animals as defined by asymmetric directed behaviors including flinching, licking, lifting, and...
The goal of this project is to build a teaching tool geared towards patients, students, and clinicians to further educate themselves about the anatomical and biochemical implications of various syndromes involving depression...
Coxiella burnetii, the known causative agent of Q fever, is an obligate intracellular bacterium capable of infecting host alveolar macrophages and residing within these cells for several years. While causing mild symptoms at...
Mobile Integrated Healthcare (MIH), also called Community Paramedicine (CP) or EMS 3.0, is a novel approach to prehospital care. With the use of specially trained paramedics, MIH-CP seeks to fill the current healthcare gaps in...
Background: Inflammatory Bowel Disease (IBD) is a chronic relapsing and remitting inflammatory disease that affects the GI tract. IBD has two major types: Crohn’s disease and Ulcerative Colitis. IBD occurs when the immune...
Hormone replacement therapy (HRT) is a common treatment for gender dysphoria, a condition where a person’s gender assigned at birth does not match their gender identify. For transgender men seeking to achieve virilization, HRT...
Coxiella burnetti is an obligate intracellular bacterial pathogen that spreads to humans via inhalation, infects alveolar macrophages and causes the worldwide zoonosis known as Q fever. Acutely, Coxiella infection manifests as...
Introduction: 23andMe provides consumers the opportunity to receive genetic information without involvement of a healthcare provider. As 23andMe continues to increase the number of variants and genetic diseases included in...
This was a case study on a patient with SLE who received a heart transplant. Patients with SLE are generally not considered to be ideal candidates for transplantation due to auto-immunity involving many organ systems....
Gestational diabetes mellitus (GDM) is an increasingly prevalent complication of preg-nancy leading to adverse maternal outcomes for years postpartum. This primary litera-ture review was conducted to explore what complications...
3D visualization research is useful as a learning tool for medical students learning human anatomy and as a diagnostic tool for practicing physicians. Here we explore the use of this application of medical imaging in...
This project, OPTIMISTIC, is a retrospective study that focuses on Congestive Heart Failure(CHF) in Indiana Nursing homes. The purpose of the study was to find better ways in which to implement in house care to these CHF...
Background: It has been observed that patients with poor mental health are relatively frequent users of the Emergency Departments (ED). The objective of this study was to evaluate the prevalence of numerous behavioral health...
There are limited data regarding the research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016 study of...
There is a lack of data regarding real and perceived barriers to research participation among osteopathic medical students (OMS’s). We have previously addressed this open question by surveying incoming first-year OMS1’s and...
Spinal muscular atrophy (SMA) consists of a group of neuromuscular disorders characterized by degeneration of alpha motor neurons, leading to a lower motor neuron-type syndrome. Children afflicted with SMA 1 and 2 are prone to...
Community Health Needs Assessments and the developed strategies corresponding to any findings provide opportunities to improve the health of communities by targeted, coordinated efforts to meet the community needs. Thomas...
Bradykinin, a local dermal kallikrein-kinin system product, increases skin blood flow via a cyclic GMP mechanism but is not the active cutaneous vasodilation molecule associated with cholinergic stimulation. However, the...
Introduction Delayed vasopressor initiation can occur with septic patients who arrive to the emergency department (ED) hemodynamically stable but decompensate later in their ED or hospital course. The relationship between...
Kidney transplantation is a major surgical intervention and patients undergoing counseling for this procedure do not always fully understand the essentials of this procedure. We present an improved way to facilitate patient...
This project created the first website capable of searching published biomedical knowledge and returning a rank ordered list of actions most effective at improving health. These actions have font scaled based on the odds ratios...
Introduction. Multiple myeloma (MM) is a hematological cancer characterized by the expansion and accumulation of monoclonal malignant plasma cells in the bone marrow (BM). Interactions between MM cells and cells of the bone/BM...
BACKGROUND: With an aging world population, there is an increased risk of fracture and impaired fracture healing. Enhancement of angiogenesis is one potential mechanism for improved fracture healing. The question then becomes:...
Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
Objective Adolescent and young adult cancer survivors (AYACS: ages 15-39) have an 84.5% five -year survival rate. AYACS have a 10 times greater risk to develop cardiac disease compared to healthy peers. This is in part due to...
Background: Recent studies indicated that chronic Salmonella infection contributes to increased risk of human colon cancer. In our previous studies, we found that Salmonella type III secretion effector protein AvrA can induce...
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While Coxiella initially infects alveolar macrophages, it may disseminate and cause endocarditis up to 20...
Introduction: In 2012, approximately 19 million adults in the U.S. used some form of manipulative treatment as part of their overall healthcare. Suboccipital release (SOR) is a commonly used manual medicine technique of the...
INTRODUCTION: Two out of five U.S. citizens born after 2014 are expected to develop type 2 diabetes (T2D). T2D patients are at increased risk for fracture and impaired fracture healing, including: increased frequency of partial...