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- ... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... media supplemented with 5% FBS, 1 ng/ml TGF-1, or 10 ng/ ml TGF-1 was placed in the bottom well. The two ...... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... transfected, reconstituted expression of Gq were allowed to migrate towards 0, 1, or 10 ng/ml TGF-1. C ...... minutes treatment with 0, 1, or 10 ng/ml TGF-1. D) G11/q-null and reconstituted cells co-expressing ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... course of oral wounds and skin wounds in group 1 (after 3 mm primary biopsy), and group 2 (after 5 mm ...... of 3 mm wounds in group 1 and 5 mm wounds in group 2 as well as the contraction percentage ...... immediately after 3 mm biopsy in group 1 and 5 mm biopsy in group 2. n.s.: not significant, *p<0.05. Error ...... . Onaitis6, Niki Moutsopoulos4, J. Silvio Gutkind2,3,*, and Maria I. Morasso1,* Author Manuscript 1 ...... Craniofacial Research, Bethesda, MD, USA 5.Biodata Mining and Discovery Section, National Institute of ...
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Onaitis, Mark W., Asselin-Labat, Marie-Liesse, Gutkind, J. S., Uchiyama, Akihiko, Callejas-Valera, Juan Luis, Abusleme, Loreto, Molinolo, Alfredo A., Edwards, Dean, Moutsopoulos, Niki M., Iglesias-Bartolome, Ramiro, Morasso, Maria I., Doci, ColleenL., and Brooks, Stephen R.
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Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We...
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- ... temperature, followed by two 5-min washes with PBS. Then the spheroids were blocked with 3% BSA in PBS for 1 h ...... Factor (VEGF) and Sphingosine-1 Phosphate (S1P). In vivo, through constitutive and inducible endothelial ...... family are Ras homolog gene family, member A (RhoA), Ras-related C3 botulinum toxin substrate 1 (Rac1 ...... of a variety of cell surface 1 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech ...... : constantinos.mikelis@ttuhsc.edu) Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 1 ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... negative staining intensities were scored as 3, 2, 1, and 0, respectively. For each of the intensity scores ...... Research ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral ...... Carcinogenesis Rifat Hasina,1 Leslie E. Martin,1 Kristen Kasza,2 Colleen L. Jones,1 Asif Jalil1 and Mark W ...... . Lingen1 Abstract Despite numerous advances, the 5-year survival rate for head and neck squamous cell ...... with preventive strategies. Using the 4-nitroquinoline 1-oxide (4-NQO) mouse model, we sought to define ...
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Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen
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Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...
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- ... , nasopharyngeal carcinoma and cervical cancer (CC) [1-19]. Using CC as a model for investigation, where LOH of ...... expression of the inhibitor of angiogenesis Thrombospondin-1 (TSP-1). One of the important features that ...... (Figure 1, first panel). Addition of cytosolic extract or ATP alone was also insufficient for transport ...... (Figure 1, second and third panels), suggesting that NOL7 localization is energy and complex dependent. At ...... 4C or in the presence of heat-inactivated cytosol, NOL7-GFP was restricted to the cytoplasm (Figure 1 ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... tissue (Fig. 2A). Tissues were scored 0, 1, or 2 based on staining intensity, with 0 being the lowest and ...... among women worldwide (1). CC development is strongly associated with human papillomavirus (HPV ...... TSP-1. Importantly, reintroduction of NOL7 suppressed tumor growth in vivo by 95% (32). These studies ...... Gynecol Pathol, Vol. 31, No. 1, January 2012 Cell Lines All cell lines were obtained from the ATCC ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... . Membranes were blocked for 1 hour at room temperature in 5% milk in TBST and then probed with primary ...... that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpressed genes in ...... beyond 5 years (9, 10). This is partially attributed to the propensity of HNSCC to metastasize to ...... , we observed that SEMA3F is among the top 1% underexpressed genes (15). SEMA3F is a member of the ...... (1). Metastasis is the leading cause of morbidity in patients with a variety of solid tumors, where ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... antitumorigenic cell phenotypes & 2013 Macmillan Publishers Limited Figure 5. NOL7 coimmunoprecipitates TSP-1 mRNA ...... . *Po3 10 5; **Po9 10 5; ***Po2 10 7. Figure 7. NOL7 post-transcriptionally stabilizes TSP-1 ...... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... in 5% milk-TBST and probed overnight. Secondary was probed at 10 ng/ml for 1 h at room temperature ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... DSG3 (fg mL-1) 40 750 500 250 30 DSG3 PDDA HRP Ab2 I, nA 100 AuNPs 50 20 25 5 10 10 0 0 1 m ...... = 0.99315 30 I, nA 25 20 15 10 5 Voltage + H2O2 HQ amperometric signal 0 100 10 C 1000 [DSG3], pg mL-1 1000 ...... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... reproducibly detect DSG3 protein at levels down to 5 fg mL 1 in complex tissue extracts, with minimal non ...... 26 April 2012 Received in revised form 19 July 2012 Accepted 1 August 2012 Available online 23 ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... known Broods Chicks EPY 5 2a 4b 4 17 7 14b 13 1 1 1 0 2 1 8 5 0 0 18 64 3 considered the putative father ...... KCl, 1% Triton X-100t, 5% DMSO, 2 mM MgCl2, 0.25 mM each primer, 0.1 mM each dNTP, and 1.5 mCi 35S ...... with putative fathers identified, three were the result of extra-pair copulations (5%). Three of 18 ...... November 2001. 1 Present address: Department of Biology and Environmental Science, Marian College, 3200 ...... , tres (5%) fueron el resultado de copulaciones extra-pareja. Tres de 18 nidadas (7%) presentaron hijos ...
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The White-tailed Ptarmigan (Lagopus leucurus) is one of the few socially monogamous species within the highly polygynous grouse subfamily (Tetraoninae). I found White-tailed Ptarmigan in Glacier National Park, Montana,...
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- ... and can be up to 1 m wide and 100 m long (Berry 1923, Rebertus 1986, Butler and Malanson 1994, Gurnell ...... 92 PROCEEDINGS OF THE INDIANA ACADEMY OF SCIENCE Figure 1.Beaver-dredged canals and cut stumps in ...... Indianapolis, IN.; (1.) Shows location of Eagle Creek, Fishback Creek, and Nina Mason Pulliam EcoLab beaver ...... Marian University on Crooked Creek (39.818161N, 86.205897W; WGS84; Figure 1). In both the Fishback Creek ...... Crooked Creek (Figure 1). Canal systems often contain dry segments, segments containing water, and check ...
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Kot, Amanda, Nicholson, Jody, Black, Matt, Abbott, Matthew J., Wilson, Jon, Thomas, Adam, Schaffer, Benton, Fultz, Brandon, Benson, David P., and Burrows, Mallory
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Castor canadensis Kuhl (North American beavers) are central place foragers who
collect woody plants and building materials from their surroundings and return to a main body of water containing a lodge or food cache. It has...- Type:
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- ... 5 0 shControl 1 0.0004 0.0003 0.0002 0.0001 0.0000 shControl J shControl shRictor shRictor 40 20 0 1 ...... 2 H 0.3 0.2 shRaptor 1 shRaptor 2 0.1 25 20 15 10 ** *** 5 0 0.0 shControl 1 2 shRaptor shRictor ...... . Inhibition of mTOR complex 1 (mTORC1) by rapamycin [drug concentration causing 50% inhibition (IC50) = 5 nM ...... cells 20 5 shCXCR4 0 28 Time (days) 50m 500m K shControl 21 H Normal LN 500m shControl shCXCR4 14 ...... Vehicle CXCL12 500m 3 I 7 *** 50 ventral tongue 60 Time (days) 0 100 80 0 10 150 100 0 1 shControl shCXCR4 ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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- ... NOS are evaluated throughout the rubric, including dimensions 1, 3, 4, and 5. For example, the ...... concerning item counts within the flowcharts. Dimensions 1 and 5 are evaluated by the rater of the flowchart ...... . 1 = nave; 2 = novice; 3 = intermediate; 4 = proficient; and 5 = expert. The total possible rating ...... 1 Difference Pre to Post and each webbed line represents an increased rating up to 5. SPFA was ...... science (NOS) and experimental design (Figure 1). In practice, the scientific process is nonlinear ...
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The scientific process is nonlinear, unpredictable, and ongoing. Assessing the nature of science is difficult with methods that rely on Likert-scale or multiple-choice questions. This study evaluated conceptions about the...
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- ... communism in the movies and in 1 real life in postwar World War II America, while Arnolds habit was to find ...... something at Pettis could view for free; otherwise children paid five cents and adults ten.1 In 1896, Edison ...... . The N.A.A.C.P., the president of Harvard, Jane Addams of Hull House, and other 1 2 Indianapolis ...... near Delaware in 1906. Called the Bijou (Now Open. Always 5 Cents), it showed prize fighters, horse ...... Clothing), Isadore Feibleman (Bamburger and Fiebleman law firm), and Morris Cohen.5 With the cost of ...
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"Traces the rise of the movie industry from its raffish nickelodeon roots in the late nineteenth century to enormous popularity in the first half of the twentieth century. Self-censorship by the movie industry to satisfy its...
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- ... . 1 Bishop Chatard: Secret Societies, Irish Nationalists, Americanists and Modernists, 1878-1918 ...... name and nation in the minds of the vast majority of the Irish.1 A Catholic cannot be an anarchist ...... . . . . Religion . . . is therefore the 1 Jay P. Dolan, The Irish Americans (Bloomsbury Press: New York, 2008), 50 ...... American Freedom, 137. 2 more necessary, the freer is the form of government."5 Such warnings that ...... . Johns Church earned $400 and $300 a year, 5 Blanchard, Catholic Church in Indiana, 112. 6 After the ...
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"This chapter deals with a set of movements that Bishop Chatard, a religious, social, and political conservative, had to deal with. Born into comfort, rector of the American College in Rome, Chatard, so far as he was able,...
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- ... box. 16 IC&R, 16 July 1954, 1. 17 IC&R, July 1959, 4. 15 18 19 20 Criterion, 14 October 1960. IC&R, 11 ...... , 2018, All rights reserved. 1 Priestly Celibacy and the Rise of National Priests Associations since ...... own household, how can he care for Gods Church? 1 Tim. 3:2, quoted by a reader from Versailles ...... , Indiana, Criterion, 20 November 1998, 5. If anyone says that it is not better and more godly to live in ...... virginity or in the unmarried state than to marry, let him be anathema.1 Council of Trent In the Old ...
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"This chapter briefly traces the history of priestly celibacy in the Catholic Church, its reasons, and the crisis in vocations the discipline created, partly as a result of the Second Vatican Council’s praise of sexuality in...
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- ... cars, guarded by conductors and porters, 1 Robert V. Bruce, 1877: Year of Violence, (Indianapolis, 1959 ...... Record, 13 September 1918, 1. 5 St. Johns on Georgia Street.16 With the antagonists, Kearney and ...... Haymarket Affair, 1886, used James, 5, 1-3, to conclude his autobiography. 57 Indianapolis Sun, 24 August ...... . 2017 William Doherty. All rights reserved. 1 The central question Catholicism faced in nineteenth ...... on strike, property losses mounted to over $5 million, with a hundred dead and a thousand imprisoned ...
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The chapter opens with a discussion of the Great Railroad Strike of 1877 in which questions regarding the social order, class, equity, and like matters arise. The coincidental arrival in Indianapolis of Denis Kearney and the...
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- ... , North Vernon, Box VI, Catholic newspaper file. 5 IC&R, 6 June 1947, 1. 6 New Wine, 43. 7 New Wine, 56 ...... 1974, 1. Criterion, 5 July 1963, 4. Such letters often carried the direction to cancel my subscription ...... Doherty 2017. All rights reserved. 1 The Archdiocesan Newspaper in the Bosler Years, 1947-1976 The ideal ...... improved archdiocesan newspaper in the hope of having every Catholic family subscribe.1 If the parish of St ...... offer, still in Rome, Bosler set three conditions: that the archbishops 1 2 Ritter papers, Schulte ...
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This chapter deals with Msgr. Bosler’s relations with two archbishops-publishers with very different approaches with regard to their editor’s independence. Bosler held that a diocesan paper ought not be a company newsletter...
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- ... Confirmation with adolescents. Sawyers eight principles are as follows: 1. 2. 3. 4. 5. 6. 7. 8. The Process ...... through Friday or an evening session could span from 5:00-8:00PM Monday through Friday. Ideally, this ...... catechesis must be profoundly revised and revitalized. General Directory for Catechesis, No. 1811 1 ...... regarding the Sacrament of Confirmation. The article also employs descriptive investigation in the 1 2 ...... Testament attributes this with Jesus being baptized by John the Baptist in the Jordan River (Mark 1:911 ...
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This article will briefly address the origins of confirmation and the current approaches to adolescent confirmation. Moreover, the article discusses the two predominant models of confirmation in the Catholic Church in the...
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- ... | FRANKLIN | LATTA | MCDOWELL WLN Table of Contents 1 Editor's Note Muriel Harris 2 Taking Initiative: The ...... directors job be a staff position or a faculty one? Please see page 29 for how to respond. 1 MURIEL HARRIS ...... to prove that claim.1 The data for the project is a collection of ten audio files recorded by five ...... the types of comments in terms of percentages (table 1). TABLE 1: Numerical and Percentage Comparison ...... . He ran a chi square test in order to determine whether the difference was due to chance.5 He found ...
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