While utilization of Kidney Paired Donation (KPD) continues to increase, the potential is not fully realized. We surveyed kidney transplant (KTX) professionals to evaluate perceptions of barriers and solutions to increasing KPD...
Osteoporosis is a disease that results from changes in bone mineral density (BMD). In the United States, over 10 million people have low BMD and have an increased risk for fractures, hospitalization and mortality. BMD is the...
30-60 min. Changes in SkBF spectral power in VLF and LF ranges from baseline to heating were determined using fast-Fourrier transform. Both groups increased spectral power within both the VLF and LF ranges. Compared to healthy...
Stomach dehiscence from the abdominal wall is a serious and potentially life-threatening complication of gastrostomy tube changes. A prospective series of 1136 gastrostomy tube changes in 415 different patients is examined to...
Candida albicans and Gardnerella vaginalis are two common infectious organisms of the female urogenital tract. Single agent boric acid (BA) topical preparations have been a treatment for resistant gynecologic Candida and...
MU-COM Research Day is an annual showcase of the the research engagement of the students within the College of Osteopathic Medicine. Content on display are typically poster presentations along with faculty-led discussions of...
6-MERCAPTOPURINE FOR SEVERE ATOPIC DERMATITIS IN A LACTOSE-ALLERGIC CHILD Pediatric atopic dermatitis (AD) is encountered routinely in the gen- eral dermatology clinic, and most children with AD have readily- manageable mild to...
Satellite cells are skeletal muscle stem cells that provide myonuclei for postnatal muscle growth, maintenance, and repair/regeneration in adults. Normally, satellite cells are mitotically quiescent, but they are activated in...
Case Study:
Short Limbs, Earlier Diagnosis: Antenatal Presentation of Cornelia de Lange Syndrome.
30-year old female presented at 35 weeks gestation to Maternal-Fetal Medicine with intrauterine growth restriction (IUGR) •...
This paper explores one of the underappreciated reasons for lack of efficacy in certain cases of antimicrobial therapy, namely the occurrence of a non-genetic resistance to antimicrobial drugs due to a metabolic quiescence of...
Background: Farnesol is added to numerous consumer products that intentionally, or inadvertently come in contact with tissues that may harbor the opportunistic yeast, Candida albicans. Objective: This study explores biological...
The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGF?) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...
This experiment analyzes three different techniques used in literature to detect cytokine release from cells in vitro: the Human Cytokine Array (HCA) by R&D Systems, the BD Cytometric Bead Array (CBA) assay, and protein...
Background We present 3 likely cases of testicular dysgenesis syndrome (TDS) within a community of chimpanzees (<em>Pan troglodytes schweinfurthii</em>). We tested whether genetic drift may be the culprit, as a genetic cause...
Background: A sterile surgical marking pen is commonly used during anterior cruciate ligament reconstruction (ACLR) to outline the proposed skin incision and then to mark the graft during preparation. Once in contact with the...
Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
BACKGROUND: Patients with an acute ischemic stroke (AIS) following cardiac catheterization (CC) generally do not receive intravenous thrombolysis [intravenous tissue plasminogen activator (IV-tPA)] as it is contraindicated due...
BACKGROUND: Trigeminal Neuralgia (TN) is a well-recognized facial pain syndrome. Discrete forms with disparate pain symptoms include TN1 and TN2, however, atypical facial pain includes neuralgiform pain along a spectrum. The...
Although the variations in brachial artery branching patterns are commonly observed, only 3.75% exhibit a high ulnar artery variation1. An even fewer number present with a bilateral superficial ulnar artery, as was reported by...
1. The Problem. “Proportionate means,” “ordinary means,” “the principle of double effect,” “moral certitude,” and “proximal material cooperation” are some of the philosophical concepts used in medical ethics. Oftentimes,...
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. While significant advances in the...
Note: supplemental powerpoint slides available below. and OBJECTIVES: Arch branching has never been shown to influence recoarctation after extended end-to-end anastomosis via thoracotomy, yet in each study bovine arch...
Marfan syndrome (MFS) represents a genetic disorder with ranging clinical presentation, most notably ascending aortic aneurysms. There has been extensive research to elucidate the mechanistic biochemistry of this disease. In...
The placement of permanent and temporary cardiac epicardial pacemaker leads through minimally invasive cardiac surgery (MICS) access remains a challenge. A reliable ergonomic approach for remote lead placement requires improved...
Bovine aortic arch is an anatomical variant in which the innominate and left common carotid arteries share a common origin. It is generally considered to be benign. The current literature estimates its prevalence may be as high...
Numerous surgical approaches have been proposed to treat aortic arch hypoplasia (Figures 1&2). These repairs can vary based upon patient age (i.e. neonatal vs larger child), and therefore the mobility of the aorta. Most repairs...
BACKGROUND: We examined the short- and long-term efficacy and tolerability of a cross-titration algorithm from oral dopamine agonists to the rotigotine transdermal patch in patients dissatisfied with their restless legs...
INTRODUCTION: Stomach dehiscence from the abdominal wall is a serious and potentially life-threatening complication of gastrostomy tube changes. This retrospective study evaluates gastric aspiration as an inexpensive and safe...
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common "gold standard" resource used building curricula are medical objectives suggested by national...
Hypersensitivity pneumonitis is a unique form of interstitial lung disease that is diverse in its presentation and etiology. • Hypersensitivity pneumonitis is mediated by an inflammatory reaction to inhalation of an...
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
Specifically in the medical field, Catholic providers rarely receive extensive education regarding the applications of moral theology to their work. Those knowledgeable on the topic have often gone to great lengths to acquire...
Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-? family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and...
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-? family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate...
Osteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer...
Visualizing the spatial relationships of anatomical features, gross pathologies, and diagnostic findings is a fundamental part of the training of medical students and other learners in health-professions curricula. But to what...
Amyloid beta (A?), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic A? fibers historically seen postmortem. While Alzheimer targets, such as...
<strong>Targeting early steps in amyloid-beta production:</strong> Alzheimer's disease (AD) has a long history as the “amyloid deposit” disorder. Many disorders are now known to be caused by protein ?-sheet misfolding and...
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor (TGF)-? family of ligands and exert most of their effects through the canonical effectors Smad1, 5, and 8. Appropriate...
Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...
Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...
The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is...
Bone morphogenetic protein (BMP) signaling has been linked to the development of pulmonary hypertension (PH). Inhibitors of differentiation (ID) proteins (ID1-4) are a family of basic helix-loop-helix transcription factors that...
While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...
Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
Bone graft incorporation depends on the orchestrated activation of numerous growth factors and cytokines in both the host and the graft. Prominent in this signaling cascade is BMP2. Although BMP2 is dispensable for bone...
The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...
The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...
Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-? family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical...
More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
The special sense of taste guides and guards food intake and is essential for body maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while G protein-coupled receptors (GPCRs) of the taste...
The transforming growth factor ? (TGF-?) superfamily is a large group of signaling molecules that participate in embryogenesis, organogenesis, and tissue homeostasis. These molecules are present in all animal genomes....
Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs) and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between...
T1R3 is a T1R class of G protein-coupled receptors, composing subunit of the umami taste receptor when complexed with T1R1. T1R3 was originally discovered in gustatory tissue but is now known to be expressed in a wide variety...
Background and Review of Literature: Subjective methods for assessing airway device cuff pressures (CP) remain in use to determine correct inflation, despite evidence indicating inadequate sensitivity for identifying under and...
Background and Review of Literature: Lumbar plexus block and fascia iliaca block are two commonly used anesthesia modalities for patients underdoing hip arthroplasty at Union Hospital in Terre Haute, Indiana. Currently, there...
Background: Inadvertent perioperative hypothermia (IPH), defined as recorded temperature at or below 36°C (96.8°F), is a common adverse effect that can occur during any surgical procedure, leading to increased postoperative...
There has been increased attention to pain control as well as patient satisfaction following surgical procedures. The interest in pain control coupled with the growing opioid epidemic has prompted anesthesia providers to...
Background and Review of Literature: Postoperative nausea and vomiting (PONV) is one of the most common patient complications following general anesthesia. Recent literature supports the practice of supplemental intravenous...
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are the Main Hall, Side Hall, Reception Room, and Library. The patterns of the wood...
A title handwritten in blue pencil reads "Mr. J.A. Allison Music Room." The scale is 1/2" = 1'. The date "May 17, 1912" is stamped at the bottom middle of the drawing. A stamp at the top right of the drawing reads: Established...
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are Chambers 2 & 3 and Closets. The patterns of the wood floors are drawn and shaded...
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are the Billiards Room and Den. The patterns of the wood floors are drawn and shaded...
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are the Stair Hall, 2 Side Halls, and the Stair Landing. The patterns of the wood...
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are Chamber 1, two Closets, and a Passage. The patterns of the wood floors are drawn...
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are Chamber Closet, and a Passage. The patterns of the wood floors are drawn and shaded...
This is a blueprint drawing (blue background with white lines) of the plan of the Marian College campus showing various buildings, athletic fields, and a lagoon. A north arrow is present near the middle on the right side. A...
This item is a mapping of study sites indicated by the Minnesota Environmental Sciences Foundation in their survey of the wetlands preserve at Marian College, now titled the Nina Mason Pulliam Ecolab.
This is an architectural drawing by famed landscape architect and conservationist Jens Jensen, concerning the detailed planting plan for the garden area at the estate of James Allison, now Allison Mansion at Marian University,...
Hennepin Loam, This item is a soil survey of the Wetlands Ecological Laboratory, now titled the Nina Mason Pulliam Ecolab. Soils listed include:Filled Land, Genesee Silt Loam, Miami Clay Loam, and Sloan Silt Loam
This drawing is on heavy brown paper. The various rooms are labeled and the various types of wood to be used are indicated. The rooms shown are the Dining Room and Breakfast Room. The patterns of the wood floors are drawn and...
This is a blueprint drawing (blue background with white lines) of the swimming pool area in the basement of the Allison Mansion. It shows the pool, women's shower room & locker room, and the men's shower room & locker room. The...
This is a general vegetation survey of the Ecolab wetlands, now titled the Nina Mason Pulliam Ecolab. Vegetation types and areas include: Hardwood Forest, Prairie, Lowland Meadow, Mowed Grass, Lowland Forest, Young Hardwood...
This is a blueprint drawing (blue background with white lines) of the front of Allison Mansion. It has no scale. A note in the bottom right says "511-1." A note on the back says "Library (Allison Residence); Architect-Herbert...