Polyphenolic compounds (anthocyanins, flavonoid glycosides) in berries prevent the initiation, promotion, and progression of carcinogenesis in rat’s digestive tract and esophagus, in part, via anti-inflammatory pathways....
Hypoxia is a critical stress that can affect the normal development of a mammal embryo. Normally, Hypoxia is buffered by the Utero-placental apparatus in human infants; however, prematurely delivered infants may encounter...
In the study, we are analyzing the human genome in order to determine patterns that may tell something about how DNA functions. Patterns require an explanation: it is highly improbable that they are random occurrence. These...
Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
2 fold, either as a vector-expressed shRNA or as a transfected siRNA. We randomly mutagenized gFA2 to create a gFA2 variant sub-library. We screened this sub-library in primary FA fibroblasts and identified two gFA2 variants,...
Background: Zone based photodynamic therapy (PDT) is a promising treatment option for actinic keratosis, superficial basal cell carcinoma, and in-situ squamous cell carcinoma. PDT has similar cure rates to 5-fluorouracil and...
The Transforming Growth Factor-beta (TGFβ) superfamily is a large group of signaling molecules whose members play conserved roles in embryo specification, organogenesis, and tissue homeostasis. Structural considerations...
Osteoporosis is a disease of low bone mineral density (BMD) that affects 10 million Americans with an additional 34 million at risk for developing the disease. Current FDA-approved therapies for osteoporosis involve...
Sympathetic-like axon reflexes drive the initial increase in blood flow of the biphasic cutaneous vasodilation response of non-glabrous skin to local heating. It is currently unknown whether this process is involved in the...
The design, administration, input, and evolution of an epigenetic database containing metadata across studies was created using cloud based tools with permission and blinding capacities. The database was designed to store the...
Background: Transposition of the Great Vessels (TGV) is a congenital heart defect (CHD) in which the great vessels are reversed – the aorta arises off of the right ventricle and the pulmonary trunks arises off the left...
New imaging technologies and 3D rendering software, in addition to being useful diagnostic tools, allow us to augment patient education and further medical student and physician knowledge. 3D imaging modalities such as CT and...
Unemployment is a substantial problem amongst veterans with mental illness. This pervasive vocational dysfunction results in poor financial, clinical, quality of life, and psychosocial outcomes. The Cognitive Behavioral Therapy...
Osteoporosis is a disease of low bone mineral density that affects 10 million Americans and accounts for 1.5 million fractures annually. With an additional 34 million Americans at risk for developing the disease, osteoporosis...
Cold-induced vasodilation (CIVD) is a phenomenon involving a counterintuitive increase in skin blood flow during cold exposure. Although CIVD was first described in 1930, CIVD mechanisms remain unknown. CIVD research has...
Fibroblast growth factor-23 (FGF23) controls key responses to systemic phosphate increases through its phosphaturic actions on the kidney. In addition to stimulation by phosphate, FGF23 positively responds to iron deficiency...
Clostridium difficile infection is particularly common in SOT patients and the consequences are severe. Fecal microbiota transplantation is an emerging, highly efficacious therapeutic modality for CDI but data on FMT success in...
We sought to evaluate a novel PPARδ inhibitor and explore whether this compound could synergize with known chemotherapeutic compounds to kill cancer cells in culture. Methods: A novel PPARδ inhibitor compound, Compound 9, was...
In conjunction with recent curricular changes at US medical schools, histology instruction has undergone significant changes. One major change has been the steady shift from traditional microscopy laboratory sessions to the...
Bristles are mechanosensory organs in the Drosophila peripheral nervous system composed of four cells that adopt different fates and differentiate. These four cells (neuron, shaft, sheath, and socket) arise from a sensory organ...
Many Gram negative bacteria including Salmonella enterica species exhibit evolving multi-drug resistance coded for on their chromosome and on mobile genetic elements. Salmonella species carrying multi-drug resistance plasmids...
Under the Hospital Readmission Reduction Program (HRRP), hospitals with high readmission rates are penalized by reductions in Medicare reimbursements. In particular, Parkview Noble hospital has experienced high readmission...
Purpose: The purpose of this study is to identify which texture analysis metrics calculated from apparent diffusion coefficient (ADC) maps from patients with head and neck squamous cell carcinomas (HNSCC) provide quantifiable...
Multiple drug resistance is becoming increasingly problematic in the U.S., where antibiotics are overused both in agriculture and healthcare. One way bacteria can develop this resistance is through acquisition of antibiotic...
The goal of the IMPLICATION project is to provide a tool that will keep the already busy Physicians or Scientists up to date on the latest discoveries, in their respective specialties by providing a faster way to access the...
Persisters are a special group of quiescent and phenotypically unique cells in a given microbial population that survive antimicrobial insults or stresses but retain properties of the original population. Persisters have been...
Vibrio cholerae colonization of the host requires stringent response activation of TCP, the Toxin-Coregulated Pilus Cholera is an epidemic diarrheal disease caused by the Gramnegative bacterium Vibrio cholerae. In order to...
Palladium is often used in the synthesis of Active Pharmaceutical Ingredients (APIs), although it is toxic to ingest. As it is difficult to remove, it is imperative to develop optimal palladium sensors that can be utilized in...
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and is a significant health problem and a considerable socioeconomic burden. Current treatments for osteoporosis have significant limitations,...
3D Visualization is a growing field in medicine. It is used for diagnosis, intervention design, and patient education. Medical students and physicians have little difficulty picturing a heart in their mind. Most physicians and...
It is estimated that more than 500,000 bone grafting surgeries occur yearly in the US to repair or replace defects caused by trauma, tumor resection, pathological degeneration and congenital malformations. Significant progress...
Cryoglobulinemia is a condition where immunoglobulins precipitate at temperatures < 37°C causing damage to blood vessels of the skin, joints, peripheral nervous system, and kidneys. Diagnosis is difficult due to various...
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
Insulin resistance is associated with a high cumulative risk of AD and reduced cerebral glucose metabolism. New data suggest that increased hexosamine biosynthesis pathway (HBP) activity induces insulin resistance in adipose...
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α2δ1 VSCC subunit regulates osteocyte...
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Substantial evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone...
The Activin and BMP signaling pathways exert reciprocal effects on myogenesis and skeletal muscle regeneration after injury. Signal transduction in both pathways is mediated by ligand- induced activation of transcriptional...
Context: Though anatomy is a vital part of a medical student’s education, three-dimensional visualization often ends in the laboratory, months into a medical student’s journey to becoming a physician. Many physicians would...
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and triggers significant health problems and considerable socioeconomic burdens. Current treatments for osteoporosis have significant...
1.0°C. Arm and leg SkBF (laser-Doppler flowmetry) was decreased by engaging the venoarteriolar response (limb lowered ~30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous...
Osteoporosis is a disease of low bone mass resulting from bone resorption exceeding bone formation that places individuals at enhanced risk for fracture, disability, and death. There is an urgent and unmet need for novel...
30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous occlusion by proximal cuff inflation; CVAR with DPP), and ischemia (arterial occlusion by proximal cuff inflation) and sweat...
Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
There are limited data regarding the level of research experience and/or interest among osteopathic medical students despite a rapidly increasing enrollment and expansion of the number of osteopathic medical schools. A 2016...
Context: Patients with large staghorn calculi are commonly treated with percutaneous nephrolithotomy (PCNL). PCNL access can be technically challenging and has potential to result in significant radiation exposure to both the...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteoclasts, and osteocytes. WNT signaling through low-density lipoprotein receptor related protein 5/6 (LRP5/LRP6) is one of the...
Introduction: According to the Centers for Disease Control and prevention (CDC), ensuring student access to needed physical and mental health care improves attendance, behavior, and achievement in the classroom. Academic...
In order to determine if loss of cell wall integrity contributes to boric acid toxicity towards wild type and drug resistant Candida organisms, yeast growth in osmoprotective-high-sorbitol medium was compared to growth...
Context. Metabolic syndrome (MetS) refers to the combination of abdominal obesity, hyperglycemia or insulin resistance, dyslipidemia, and hypertension. MetS has been associated with morbidity and mortality after a variety of...
Students frequently report difficulty learning information presented at the end of long study sequences. Prior research has shown that information presented earlier in a study sequence interferes with learning of information...