Cryptococcus neoformans (Cn) is a pathogenic yeast that is the leading cause of fungal meningitis in immunocompromised patients. Various Cn virulence factors, such as the enzyme laccase and its product melanin, phospholipase,...
Raised just outside Cincinnati, in the rural community of Rossmoyne, Ohio, Aaron Belford Thompson, Priscilla Jane Thompson, and Clara Ann Thompson wrote poetry that addressed Black American life in the early twentieth century....
A selection of sources for the cultural and political context of the early Roman Empire and the New Testament writings, this book includes public speeches, official inscriptions, annals, essays, poems, and documents of veiled...
The article demonstrates a need and placement of Roman Catholic pastoral theology and serves to offer important revelations about the state of pastoral theology in the Catholic tradition. The overarching goal of this article is...
Voltage sensitive calcium channels (VSCCs) are key components in coordinating extracellular signaling that influence calcium (Ca2+) influx and subsequent downstream signaling in a variety of tissues including bone. Previous...
Mental illness treatment in the United States has developed and changed drastically in the past century. Where in the early 1900s,one with a severe mental illness would be institutionalized, today, the same person could be...
Vibrio cholerae is a Gram-negative bacterium that is the cause of the diarrheal disease cholera. Many strains have developed antibiotic resistance which allows these mutated strains to elude traditional treatment. Among the...
Introduction: Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. The PKC and ROK play critical roles in cell division, migration, and survival. However, the roles of protein kinase-c (PKC)...
, and yl, y2, and y3
• We continue to learn more about the involvement of PPARs in
immune modulation.
Conclusion
• Further understanding PPARs upstream pathways and interactions can contextualize pathophysiology in...
Peroxisome proliferator-activated receptors (PPARs) are important nuclear receptors in regulating macrophage lipid metabolism and modulating cellular inflammatory responses. In recent years, host cell PPARs have been linked to...
Osteoporosis is a silent, dangerous, pathology frequently undiagnosed until patients experience a major fracture. Fractures from osteoporosis lead to a 20% increase of mortality, revealing a need for novel anabolic therapies....
Coxiella burnetii is an obligate intracellular bacterial pathogen and causative agent of Q fever. Chronic Q-fever manifests as potentially fatal endocarditis weeks to years after initial infection, suggesting Coxiella’s ability...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. They are surrounded by a phospholipid monolayer and store excess cellular free fatty...
Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy
(cART)?
• The brain is a known reservoir for HIV.
• HIV can act on myeloid cell populations like...
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While Coxiella initially infects alveolar macrophages, it may disseminate and cause endocarditis up to 20...
Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage diagnoses...
•Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. •HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage...
Obesity and metabolic dysfunction negatively impacts many tissues, including the skeleton. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase and key regulator of whole-body...
There is a need for anabolic therapies to treat degenerative bone
diseases. Mechanical loading stimulates anabolic and inhibits
catabolic pathways of bone leading to increased bone formation.
Osteocytes are the bone cell...
Bradykinin, a local dermal kallikrein-kinin system product, increases skin blood flow via a cyclic GMP mechanism but is not the active cutaneous vasodilation molecule associated with cholinergic stimulation. However, the...
While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
Coxiella burnetii is an obligate intracellular bacterium responsible for causing culture negative endocarditis. The manifestation of this condition several years following initial infection exhibits Coxiella’s ability to...
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. While significant advances in the...
In his book, Music Education in an Age of Virtuality and Post-Truth, Woodford presents a welcomed discussion of the aims of music education in a time of political unrest. This timely text is needed due to the stresses of the...
COVID-19 was primarily identified as a respiratory illness, but reports of patients presenting initially with cardiovascular complaints are rapidly emerging. Many patients also develop cardiovascular complications during and...
<b>Background and Review of Literature</b>: Caesarean sections are one of the most performed procedures in the operating room. Managing pain for these patients is vital to ensure a positive birthing experience for mothers and...
Background and Review of Literature: Postoperative nausea and vomiting (PONV) frequently occur in patients after anesthesia, significantly impacting patient satisfaction and potentially leading to untoward complications....
Community Health Needs Assessments and the developed strategies corresponding to any findings provide opportunities to improve the health of communities by targeted, coordinated efforts to meet the community needs. Thomas...
In 1984, Ultrasound-Guided (USG) Intravenous (IV) access was first used to place central venous catheters (CVC) in real-time. This led to increased success rates, reduced procedural times, decreased site associated...
Practitioners of course-based undergraduate research experiences (CUREs) often evaluate student learning through journal article style lab reports. In our biology department, CUREs are used in multiple required and elective...
Religion Matters: How Sociology Helps Us Understand Religion in Our World focuses on religion’s interplay with broader society, introducing students to the basic questions, ideas, and methods with which sociologists have...
Introduction Delayed vasopressor initiation can occur with septic patients who arrive to the emergency department (ED) hemodynamically stable but decompensate later in their ED or hospital course. The relationship between...
Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and...
Background: The lack of palliative care (PC) services poses a significant risk for PC patients. Research indicates that patients' needs often go unmet when PC referral processes are not well established within a health system....
In the intraoperative setting, the intersection of hand hygiene practices and contamination of the anesthesia workstation presents a critical juncture for reducing hospital acquired infections that ultimately lead to increased...
This article presents seven points of focused dissonance between Jeremiah and Romans, by identifying how Romans 9–11 inverts the judgment language of Jeremiah 1–20 against Judah. Without claiming that the inversions in Romans...
Exploring the intersection between Chicago's eight-hour movement and Protestant religious culture over a fifty-year span, this project considers how workers and clergy contested the religious meaning of the eight-hour system...
We argue that one of the best ways to improve equity and diversity in the plant sciences begins in the undergraduate
classroom. Our classrooms are the first stop for the next generation of plant scientists, and we must engage...
This article discusses the collaborative digitization effort between librarians at Marian College (now Marian University) and Indiana University Purdue University Indianapolis (IUPUI) to create a deliverable online collection...
Presented in the Active/Collaborative Learning track. and Student engagement and collaborative learning is enhanced by following the customized "Internship Playbook." A large population of the students in the School of Business...
Over 1.25 million people reside in nursing facilities in the United States. Nursing facilities have reported 268,707 confirmed cases of COVID-19 and 61,765 COVID-19 deaths as of the week of November 2, 2020. Indiana was one of...
Recent studies describe racial and socioeconomic
(SES) disparities with mechanical thrombectomy
(MT) for acute ischemic stroke (AIS). Our study
investigated whether such disparities are present at
our institution and...
Healthcare disparities among different racial and ethnic groups are prevalent across the United States and worldwide. Healthcare provision may differ among racial and ethnic minorities, socioeconomic statuses, and insurance...
This article is an invitation to Christian youth and young adult educators and ministers to be more understanding of queer theology and to discern its place within ministry to and for young people. The article examines the term...
The LGBT+ community is generally grouped into one big group with all the same needs by media, organizations, and people. However, LGBT+ people have different concerns and needs based on age, race, ability, and so many other...
<b>Background</b>: Many surgical procedures require muscle paralysis of the patient to ensure optimum operating conditions. Monitoring the level of paralysis is an important responsibility of the nurse anesthetist throughout...
A presentation at the 2017 Higher Education Partnership: Internationalization in the Americas conference in San Miguel de Allende, Mexico (sponsored by the Partners of the Americas organization). This presentation outlines the...
Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super...
Medication errors and interactions happen every day in the perioperative setting. It is the responsibility of the post-anesthesia care unit (PACU) nurse to manage pain, nausea, vomiting, and maintain hemodynamics after surgery...
Background: The implementation of a standardized warming protocol aims to prevent hypothermia in the postoperative period. Hypothermia in the postoperative period can result in inadvertent adverse outcomes for patients...
Within the last quarter of the twentieth century and now well into the twenty-first, the historical novel has been a prolific and popular form in Spain for commentary on the dictatorship, the Transition and contemporary...
Presented in the Innovative Assessment of Learning track. and MAT250 transitions students to advanced mathematics. Objectives include learning to justify mathematical statements using standard methods of proof and communicate...
The chapter opens with a discussion of the Great Railroad Strike of 1877 in which questions regarding the social order, class, equity, and like matters arise. The coincidental arrival in Indianapolis of Denis Kearney and the...
The United States spends well over $100 billion for millions of people affected by Alzheimer’s disease and related dementias (ADRD) and for their family caregivers. Most people with ADRD have multiple chronic comorbid...
"This chapter briefly traces the history of priestly celibacy in the Catholic Church, its reasons, and the crisis in vocations the discipline created, partly as a result of the Second Vatican Council’s praise of sexuality in...
Background: Due to globalization, spread of a pandemic is inevitable as we have seen with COVID-19. Further, increased ease of travel increases the potential and frequency of pandemics. Hence, it is imperative to find solutions...
Background: It has been observed that patients with poor mental health are relatively frequent users of the Emergency Departments (ED). The objective of this study was to evaluate the prevalence of numerous behavioral health...
Children with acute lymphoblastic leukemia
(ALL) suffer a litany of therapy induced side
effects. Methotrexate is a common chemotherapy agent
administered for the treatment of ALL. Failure to clear methotrexate from the body...
Declining fitness (˙VO2 peak) is a hallmark of ageing and believed to arise from decreased oxygen delivery and reduced muscle oxidative capacity. Physical activity is a modifiable lifestyle factor that is critical when...
In the United States, one of the biggest issues that every state is experiencing is the shortage in doctors. Primary Care Physicians make up a huge percentage of the shortage in doctors. The Midwest took a huge hit by this...
<b>Background and Review of Literature</b>: This study examined individual opinions from healthcare providers in Indiana about their willingness to prescribe Pre-Exposure Prophylaxis (PrEP) for Human Immunodeficiency Virus...
Patients with class three obesity, formerly defined as morbid or extreme obesity, presenting for anesthesia come with an increased risk of experiencing complications. The oxygen storage capabilities and the functional residual...
Inadequate pain management during a laparoscopic cholecystectomy can affect postoperative hemodynamics, impair recovery, and extend hospital stay. The use of opioid medications during and after surgeries can reduce...
There has been increased attention to pain control as well as patient satisfaction following surgical procedures. The interest in pain control coupled with the growing opioid epidemic has prompted anesthesia providers to...
Presented in the Active/Collaborative Learning track. and The value of introducing graphic design majors to the process of co-design, designing with stakeholders rather than for them, is essential to the education of today's...
Practicing empathy and listening skills are not traditionally components of a graduate-level biomedical science curriculum, however incorporating an opportunity for students to refine both can be given using “patient” podcast...
The Power of Touch is written to enlighten on the anatomy and physiology of touch within the brain and how such integration influences our interpretation of objects under tactile stimulation. Touch conveys great power to...
Animals evolve in complex selective regimes, where a suite of different factors can shape signal use. We might predict that more closely related species will exhibit more similar behavior than those more distantly related;...
Educational techniques are constantly evolving because of influences from technology and improvements in the resources that are available to educators as well as learners. An educational adjunct, such as a podcast, may help...
Educational approaches are constantly evolving due to of influences from technology and improvements in the resources that are available to educators as well as learners. Current literature suggests that utilizing podcasts in...
This is a blueprint drawing (blue background with white lines) of the plan of the Marian College campus showing various buildings, athletic fields, and a lagoon. A north arrow is present near the middle on the right side. A...
This is an architectural drawing by famed landscape architect and conservationist Jens Jensen, concerning the detailed planting plan for the garden area at the estate of James Allison, now Allison Mansion at Marian University,...
This research project investigates lead exposure in urban areas, focusing on community gardens with lead-contaminated soils. Lead exposure causes brain damage, IQ decrease, and behavioral problems. Lead is one of the health...
Many triggers for shame that lead to physician burnout occur during patient care or the medical learning environment. Many resilience programs are available to medical students and physicians, yet incorporate non-faith...