Klotho is a regulatory anti-aging protein that is significantly expressed
in the choroid plexus, plays an important role in regulating the immune
response in the CNS, and diminishes with age. Klotho deficiency is...
3D visualization software is a useful tool in
patient education because it allows patients to
put an image to what a physician is describing
to them. With an emphasis on education of
young athletes on the potential...
Multiple sclerosis (MS), one of the most
prevalent immune-mediated neurological
disorders, is a chronic demyelinating disease
of the central nervous system that affects both
white and grey matter (Avasarala et....
Children with acute lymphoblastic leukemia
(ALL) suffer a litany of therapy induced side
effects. Methotrexate is a common chemotherapy agent
administered for the treatment of ALL. Failure to clear methotrexate from the body...
Calcitriol is a vitamin critical in regulating calcium
homeostasis, maintenance of musculoskeletal
integrity, and both a commonly prescribed medication
and over the counter supplement.
• However, the incidence of vitamin D...
• Myroides spp. are non-motile, aerobic, gram-
negative bacilli that are traditionally
opportunistic pathogens1.
• P. stuartii is a urease-producing, gram-negative
bacillus2.
• Myroides infections have been reported
60...
Traditionally, the acute wrist radiograph series is comprised of
posteroanterior (PA), oblique, and lateral projections. There is controversy within the field of Orthopedics, however, over the value of the oblique view in...
In 1984, Ultrasound-Guided (USG) Intravenous (IV) access was first used to place central venous catheters (CVC) in real-time. This led to increased success rates, reduced procedural times, decreased site associated...
Background and Review of Literature: A surgical site infection after posterior instrumented spinal fusion can negatively affect the patient and increase healthcare costs. Spinal fusions are becoming increasingly common as a...
Background: A child’s pain is different from pain experienced as adults. Different emotional and psychological factors can affect the child’s pain comprehension and stimulate their response to pain. Procedural pain can have...
Background: Many patients seek the advise from their primary care providers (PCPs) to provide insight into alternative treatment options, however, little is known about the practices of primary care providers (PCPs) and the...
The United States Preventative Services Task Force (USPSTF) recommends initiating colorectal cancer screening for asymptomatic, average-risk individuals at age 45, which is a new update to the previous recommendation of age 50....
1.5 million reported traumatic brain injuries (TBI) per year with varying degrees of severity that inflict injury at the cellular level. The Choroid Plexus (CP) plays a significant role in brain homeostasis. The CP has also...
Menopause, an age-related loss of sex hormone production in women, is one of the most common causes of osteoporosis. Previous work has established that this loss of sex hormones, in particular estrogen, causes dramatic loss of...
The dramatic increase in the prevalence of antibiotic resistant (AR) genes
in numerous bacterial species has been a heavily discussed topic within
the scientific community. Antibiotic resistant bacteria pose a serious
threat...
Ticks have been widely studied for their importance in disease transmission. In
Pennsylvania, four different ticks (associated with human diseases) are commonly
encountered: (1) Dermacentor variabilis (Rocky Mountain Spotted...
Atlantoaxial instability (AAI) is a term that is used to describe instability at the atlantoaxial joint of the cervical spine. This is often from alar ligament instability causing the dens of the axis to be prone to move...
Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy
(cART)?
• The brain is a known reservoir for HIV.
• HIV can act on myeloid cell populations like...
Background: A patent ductus arteriosus (PDA) is a common diagnosis among
extremely preterm infants. Unfortunately, this left to right shunt may result in
significant complications including pulmonary edema, pulmonary...
Correlations exist between undergraduate GPA,
MCAT, and COMLEX-USA Level 1 scores as well as
between course grades and overall COMLEX score
(Wong et al. 2009 & Sefcik et al. 2003).
• Longitudinal reports on ProgressIQ...