6-MERCAPTOPURINE FOR SEVERE ATOPIC DERMATITIS IN A LACTOSE-ALLERGIC CHILD Pediatric atopic dermatitis (AD) is encountered routinely in the gen- eral dermatology clinic, and most children with AD have readily- manageable mild to...
The placement of permanent and temporary cardiac epicardial pacemaker leads through minimally invasive cardiac surgery (MICS) access remains a challenge. A reliable ergonomic approach for remote lead placement requires improved...
Numerous surgical approaches have been proposed to treat aortic arch hypoplasia (Figures 1&2). These repairs can vary based upon patient age (i.e. neonatal vs larger child), and therefore the mobility of the aorta. Most repairs...
BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
Osteoporosis is a disease of low bone mass resulting from bone resorption exceeding bone formation that places individuals at enhanced risk for fracture, disability, and death. There is an urgent and unmet need for novel...
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α<sub>2</sub>δ<sub>1</sub> VSCC subunit regulates osteocyte...
1.0°C. Arm and leg SkBF (laser-Doppler flowmetry) was decreased by engaging the venoarteriolar response (limb lowered ~30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous...
Context: Though anatomy is a vital part of a medical student’s education, three-dimensional visualization often ends in the laboratory, months into a medical student’s journey to becoming a physician. Many physicians would...
Insulin resistance is associated with a high cumulative risk of AD and reduced cerebral glucose metabolism. New data suggest that increased hexosamine biosynthesis pathway (HBP) activity induces insulin resistance in adipose...