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1/1/2016

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  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Keyword-Übereinstimmungen:
    Schöpfer:

    Ward, Taylor

    Beschreibung:

    The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...

    Ressourcentyp:

    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

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    Schöpfer:

    Eaton, Michael and Newby, Jordan

    Beschreibung:

    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...

    Ressourcentyp:

    poster

  • Investigating the HSF1-HSF2 Interaction

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    Schöpfer:

    Jaeger, Alex, Thiele, Dennis, and Wacker, Bryan

    Beschreibung:

    The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...

    Ressourcentyp:

    poster

  • Assessing Patient Perspective of Diet and Exercise in Patients Taking Semaglutide: An Educational Intervention

    Keyword-Übereinstimmungen:
    ... enough to achieve long-term health benefits. Inclusion Criteria: 1) adult 18 years or older without ...
    ... al., 2016; Kaplan et al., 2018; Rubino et al., 2021; Updike, 2021; Wharton et al. 2022). In 2017 ...
    ... glucagon-like-peptide (GLP-1) to combat the obesity and diabetic epidemic. Project: 21 days in length with ...
    ... two data collection periods. GLP-1 prompts the body to produce more insulin, reducing blood sugar ...
    ... (glucose). GLP-1 in higher amounts interacts with parts of the brain to suppress appetite and signal ...

    Schöpfer:

    Young, Alexis

    Beschreibung:

    The DNP project aimed to: assess the effectiveness of an educational intervention focused on improving patient knowledge and receptiveness of making necessary diet and exercise changes during their semaglutide treatment...

    Ressourcentyp:

    Poster

  • HCAHPS scores as a surrogate for quality does not correlate with TQIP quality measures at a level 1 trauma center

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    Schöpfer:

    Thoma-Perry, Carley OMS-4, Jacobsen, L., Blocher-Smith, Ethan C. OMS-4, and Saxe, J.

    Beschreibung:

    BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...

    Ressourcentyp:

    Article

  • Disparities & Inequalities in Type 1 Diabetes

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    ... Disparities & Inequalities in Type 1 Diabetes By: Shehr Asghar Marian University College of ...
    ... Osteopathic Medicine MS in Biomedical Sciences Introduction Type 1 Diabetes is an autoimmune condition ...
    ... homeostasis. Optimal management of Type 1 Diabetes is achieved through insulin pumps and continuous glucose ...
    ... financially burdensome for individuals in a lower socioeconomic status who are dealing with Type 1 Diabetes ...
    ... in a 10-year span. Table 1. This cost analysis shows the cost of insulin injections, -islet cell ...

    Schöpfer:

    Asghar, Shehr

    Beschreibung:

    Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...

    Ressourcentyp:

    Poster

  • Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption

    Keyword-Übereinstimmungen:
    ... Nutrient sensing by Tas1R proteins is required for normal bone resorption Nicholas 1 Weinstein ...
    ... , Michael 1 Eaton , Stephen 1 Shively , Hannah 2 Davis , Lilian 2 Plotkin , Jonathan W. Lowery 1 1Division ...
    ... 25 3 TAS1R3 2 CTSK 20 F o ld C h a n g e 15 10 1 -actin 5 0 L o K N A RANKL R A R C N o K n L tr + l ...
    ... -Actin 14.83.523 12.882.921 0.6956 8 3 2 1 - + 6 4 2 0 0 1 0 m D 0 C 1 B m M M S S a C cc o h n a tr ri o ...
    ... n l Saccharin p S 6 K in a s e : - A c tin 10 4 0.9639 pS6Kinase 20.783.288 p E R K 1 /2 : - A c ...

    Schöpfer:

    Shively, Stephen, Davis, Hannah M, Weinstein, Nicholas, Eaton, Michael, Plotkin, Lillian, and Lowery, Jonathan

    Beschreibung:

    Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...

    Ressourcentyp:

    poster

  • The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

    Keyword-Übereinstimmungen:
    ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...
    ... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...
    ... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...
    ... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...
    ... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...

    Schöpfer:

    Zhou, G., Doci, Colleen L., and Lingen, M.W.

    Beschreibung:

    Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...

    Ressourcentyp:

    Article

  • Safety and Efficacy of Fecal Microbiota Transplantation in Patients with a History of Solid Organ Transplant and C. Difficile Infection

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    Schöpfer:

    Khan, Noor and Fischer, Monika

    Beschreibung:

    Clostridium difficile infection is particularly common in SOT patients and the consequences are severe. Fecal microbiota transplantation is an emerging, highly efficacious therapeutic modality for CDI but data on FMT success in...

    Ressourcentyp:

    poster

  • Mouse Model of Marfan Syndrome Accelerates Aneurysmal Formation through Well-Characterized TGF-? Signaling Pathways

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    ... , University of Iowa Stead Family Childrens Hospital, Iowa City, IA Results RNA sequencing of fibrillin-1 and ...
    ... * * 15 WT + Vehicle MFS + Ang II 10 * 5 0 * 25 FPKM of Fibrillin-1 Marfan syndrome (MFS) represents a ...
    ... abundance of TGF- from a mutation in fibrillin-1 is the suggested etiology. Many important signaling ...
    ... 0.0 0 W T * 1.5 W T+ A 0.0 * W T 0.5 1 Total p38 (Normalized to WT) 1.0 2 ng II 50 m 1.5 * W T+ A * 3 ...
    ... : Fragments per kb of transcript per million reads mapped of fibrillin-1 comparing wt mice with an accelerated ...

    Schöpfer:

    Turek, JW, Qian, L, Westergaard, NM, Cavanaugh, Nicholas B., and Dyle, MC

    Beschreibung:

    Marfan syndrome (MFS) represents a genetic disorder with ranging clinical presentation, most notably ascending aortic aneurysms. There has been extensive research to elucidate the mechanistic biochemistry of this disease. In...

    Ressourcentyp:

    Article