The Activin and BMP signaling pathways exert reciprocal effects on myogenesis and skeletal muscle regeneration after injury. Signal transduction in both pathways is mediated by ligand- induced activation of transcriptional...
Hypertension is an established risk factor for the development of atrial fibrillation (AF). We evaluated the association and population impact of hypertension defined using the new 2017 guidelines on risk of AF. In this...
Context: Though anatomy is a vital part of a medical student’s education, three-dimensional visualization often ends in the laboratory, months into a medical student’s journey to becoming a physician. Many physicians would...
Introduction: OPTIMISTIC is a project funded by the Centers for Medicaid and Medicare Services (CMS) that is aimed, in part, at the reduction of unnecessary hospitalization of nursing facility residents. Data from the initial...
Students frequently report difficulty learning information presented at the end of long study sequences. Prior research has shown that information presented earlier in a study sequence interferes with learning of information...
30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous occlusion by proximal cuff inflation; CVAR with DPP), and ischemia (arterial occlusion by proximal cuff inflation) and sweat...
1.0°C. Arm and leg SkBF (laser-Doppler flowmetry) was decreased by engaging the venoarteriolar response (limb lowered ~30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous...
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Substantial evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone...
Context: Patients with large staghorn calculi are commonly treated with percutaneous nephrolithotomy (PCNL). PCNL access can be technically challenging and has potential to result in significant radiation exposure to both the...
Context: In states of health, bone mass is sustained in a coordinated effort by osteoblasts, osteoclasts, and osteocytes. WNT signaling through low-density lipoprotein receptor related protein 5/6 (LRP5/LRP6) is one of the...