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- ... for 8 weeks), there were no deaths during the study. At week 4 (n = 5), 100% of animals showed ...... Research ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral ...... . Lingen1 Abstract Despite numerous advances, the 5-year survival rate for head and neck squamous cell ...... with preventive strategies. Using the 4-nitroquinoline 1-oxide (4-NQO) mouse model, we sought to define ...... angiogenesis can slow/delay the development of HNSCC. We determined that 8 weeks of 100 g/mL 4-NQO in the ...
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Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen
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Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...
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- ... % 2.9% 9.6% 0 (0) 46 (82.1) 4 (7.1) 1 (1.8) 5 (8.9) 3 (3.6) 66 (78.6) 1 (1.2) 4 (4.8) 9 (10.7) 1 (1.7 ...... ) 43 (74.1) 4 (6.9) 3 (5.2) 7 (12.1) 6 (8.1) 60 (81.1) 3 (4.1) 0 (0) 5 (6.8) 0.3% 71% 27.8% 0% 1% 0 (0 ...... ) 17.8% 9.7% 1.7% 2.6% 5 (8.9) 4 (7.1) 0 (0) 3 (5.4) 23 (27.4) 11 (13.1) 3 (3.6) 2 (2.4) 10 (17.2) 6 ...... 1,2 , Sarah Zahl 5,6 , Michael Baumann 7 and Jonathan W. Lowery 1,2,8, * 1 2 3 4 5 6 7 8 * Citation ...... not; (3) might or might not; (4) probably will; (5) definitely will. 2.4. Statistical Analyses Data ...
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Zahl, Sarah, Hum, Julia M., Jackson, Krista L., Griffin, Nicole, Lowery, Jonathan W., Nick, Benjamin, Herber, Jake, Hamby, T., Baumann, Michael, and Ogunbekun, Oladipupo
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Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and life-long learning skills, greater appreciation for evidence-based...
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- ... included bifurcation (4), duplication (14), fenestration (16), trifurcation (1), and posterior tributary (5 ...... in 4% of individuals, and this group measured under 5 mm and 3 mm in children and infants ...... ]. There is no 4 gold standard for the diagnosis of IJV pathologies, but a combination of various imaging ...... cannulations and all of them were cannulated into the left IJV or the axillary vein [4, 61, 79, 96]. A 55-year ...... patients with IJV agenesis [4]. The agenesis of IJV may be associated with malformations in the ...
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Kosnik, Natalie, Kowalski, Taylor, Lorenz, Lorraine, Valacer, Mercedes, and Sakthi-Velavan, Sumathilatha
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The internal jugular veins (IJV) are the primary venous outflow channels of the head and neck. The IJV is of clinical interest since it is often used for central venous access. This literature aims at presenting an overview of...
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- ... 3: C02 (a), 4: C02 (b), 6: C20 , 7: C60 (a), 8: C18 0 , and 9: C1 ]. 0.32%, respectively (Table I ...... FIG. 5. Charge density distribution of (a) C60 (a), (b) C60 (b), and (c) C18 0 configurations. with ...... : 11 October 2022 Published Online: 4 November 2022 Hansika I. Sirikumara,1,a) Wilson Rativa-Parada,2 ...... composites.4 Graphene, a carbon allotrope, is used as the reinforcement in this study. In the process of ...... mixer (SPEX corp.) for 4 h, with 1 wt. % of stearic acid [CH3 (CH2 )16COOH] obtained from Sigma-Aldrich ...
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Jayasekera, T., Nilufar, S., Karunanithy, R., Sivakumar, P., Rativa-Parada, W., and Sirikumara, Hansika
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Embedding carbon in metals has long been known to enhance the mechanical properties of metal carbon composites. We report the possibility of growing Al–C composites by the hot isostatic pressing method, with carbon embedded...
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- ... (4.) The 2009 map of canal system NMP EcoLab 2 showing the relationship between beaver-cut stumps ...... -tailed p 5 0.737) (Table 2 and Fig. 2). Furthermore, 90% of the 16 20 116 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 ...... % 100.00% 100.00% 61.04% 80.33% 0 0 6 6 6 6 6 6 6 6 83 261 206 451 130 178 N/A 421 N/A 932 54 30 58 96 154 ...... . 1923. Observations on a Montana beaver canal. Journal of Mammalogy 4:92103. Brenner, F.J. 1962. Foods ...
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Kot, Amanda, Nicholson, Jody, Black, Matt, Abbott, Matthew J., Wilson, Jon, Thomas, Adam, Schaffer, Benton, Fultz, Brandon, Benson, David P., and Burrows, Mallory
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Castor canadensis Kuhl (North American beavers) are central place foragers who
collect woody plants and building materials from their surroundings and return to a main body of water containing a lodge or food cache. It has...- Tipo:
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- ... of the plate (37 C, 5% CO2, 0% O2) for 4 hours. After 4 hours, 100 L of detergent (0.01N HCl with 10 ...... to the complete growth medium. Cells were incubated in an incubator (37C, 5% CO2, 0% O2) for 48 hours ...... incubated (37 C, 5% CO2, 0% O2) with the medium alone or with the appropriate supplements (different doses ...... 9/5/2023 - Open Access Bitter melon extract suppresses metastatic breast cancer cells (MCF-7 cells ...... MCF-7 cells from the effects of bitter melon extract. 9/5/2023 - Open Access Figure 1. Insulin ...
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Kakuturu, Abhinav , Choi, Heeyun , Noe, Leah G., Scherer, Brianna N., Sharma, B., Khambu, B., and Bhetwal, Bhupal P.
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Breast cancer is one of the most commonly diagnosed cancers among women, however the complete cure for metastatic breast cancer is lacking due to poor prognosis. There has been an increasing trend of dietary modifications...
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BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.
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- ... -Smad1, -5, and -8 (canonical BMP signaling), and also by phosphorylating MAPK such as Erk, Jnk, and p38 ...... (BMP3 LacZ knock-in). To examine skeletal expression of BMP3, we analyzed heterozygous mice at 4 wk of ...... Endocrinol, January 2012, 26(1):8794 FIG. 1. OBL and OCY express BMP3. Tibia from BMP3 4-wk-old LacZ knock-in ...... ). As a first step, we confirmed that W20-17 cells express Acvr2b and nous Smad1/5/8 by Western blotting ...... cells (Fig. 4A). We next confirmed that in increased p-Smad1/5/8 levels and robustly activated ...
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Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
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Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
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- ... , demonstrated consistently downregulated NOL7 mRNA and protein. Interestingly, 5 of the 13 (40%) cell lines, C-4 ...... rs2841524 39.13% 4.35% 4.35% A-G 13618177 Intron 4 4.35% G-A 13618408 Intron 5 8.70% T-C 13620207 Intron ...... (Manassas, VA) and were cultured at 371C in a 5% CO2 in humidied incubators. Media and reagents were ...... -GTAGAGTATTTT TAGTGGGGTTTATT-30 and 50 -AAACTACACCA TAACCCA-30 ) (Figure 4). The PCR program used was 941C for ...... ://links.lww.com/IJGP/A6). Cycling conditions were 941C for 5 minutes, 35 cycles of 941C for 20 seconds, varied Tm ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... the two, except between sudangrass chromosome 4 and the reference chromosome 5 (Fig. 3). In this case ...... SupplementaryFig.4.png SupplementaryFig.5.png SupplementaryFig.6.png SupplementaryTable1.docx SupplementaryTable2 ...... ), Tandem Repeats Finder v4.09 (Benson 1999) or Page 4/21 LTR_FINDER v1.06 (Xu et al. 2007). Gene ...... the gene families, gene expansion and contraction analysis was performed using CAFE 5 (Mendes et al ...... species trees were constructed by Orthofinder using FastTree (Price et al. Page 5/21 2010) version 2.1.11 ...
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Bible, Paul, W., Wang, L., Jin, P., Zheng, J., Wang, Y., Zhan, Q., Li, J., Liu, Y., and Tu, W.
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Sudangrass [ Sorghum sudanense (Piper) Stapf] is a hybrid between grain sorghum and its wild relative S. bicolor ssp. verticilliflorum and is grown as a forage crop due to its high biomass production and low dhurrin content...
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- ... the bricks (Student A) and which object will be communicated to build (Student B). Timer is set for 5 ...
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Providing safe and effective care is identified by the Quality and Safety Education for Nurses (QSEN) guidelines as an essential competency (QSEN, www.qsen.org). First semester nursing students are challenged to evaluate their...
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- ... -eutherian animal (0/136). We also identified multiple conserved transcription factor binding sites in the ...... ligands BMP2/4 and BMP5/6/7 (Dpp and Gbb in Drosophila, respectively) share dramatic identity, BMP3 is ...... TGF-b/Activin and BMP ligands [9,10] and shares only 40% amino acid identity with the ancestral BMP2/4 ...... ) supplemented with 10% FBS (Gibco). For RT-PCR analyses, cells were scraped into PBS, centrifuged for 5 min at ...... BLASTN in sequential 500 nt sections from M. musculus against the full-length 5 kb region upstream of ...
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The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...
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- ... /IL-1F2, IL1ra/IL-1F3, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 p70, IL-13, IL-16, IL-17A, IL-17E ...... ry C In +M ju r tro on 0 +M 0 y 0 5 l 5 y 20 10 l 15 15 tro 60 20 pg/mL 20 pg/mL 80 40 Run #3 IL-6 ...... Change 8 3 6 +M ur y In j t ro on +M ur y In j C y In ju r t ro y 0 In ju r 0 FR 2 l 1 FR 4 l b 2 on FR ...... on C l 0 l 0 tro Fold Change 6 Fig. 4 Graphs displaying the average fold change of each run between ...... expression [4]. Standley and Meltzer did not use the CBA in any of their studies. This experiment attempts to ...
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This experiment analyzes three different techniques used in literature to detect cytokine release from cells in vitro: the Human Cytokine Array (HCA) by R&D Systems, the BD Cytometric Bead Array (CBA) assay, and protein...
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- ... done similar to our previous work. Acetaminophen tablets with 0, 2.5, 5, and 10% crystalline API were ...... . Standard Tablet Formulation Standard acetaminophen tablets (100 mg API) were created by AbbVie at 0, 2.5, 5 ...... available from the authors. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20 ...... enabling tablet formulation [4]. Crystallinity can be an issue for BCS Class II/IV drugs if the active drug ...... acetaminophen tablets [4]. ELDI is similar to MALDI; however, ionization via an applied matrix is replaced by ...
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Khan, Salah, McVey, Patrick, Taulbee-Cotton, Brynne, Webster, G, Van Meter, Mariann, Hubbard, Nathan, Dimmitt, Nathan, and Green, Adam
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Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as...
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- ... DSG3 (fg mL-1) 40 750 500 250 30 DSG3 PDDA HRP Ab2 I, nA 100 AuNPs 50 20 25 5 10 10 0 0 1 m ...... = 0.99315 30 I, nA 25 20 15 10 5 Voltage + H2O2 HQ amperometric signal 0 100 10 C 1000 [DSG3], pg mL-1 1000 ...... more than 11,000 deaths each year in the US alone.2 The 5 year survival of newly diagnosed HNSCC ...... detection of reactive lymph nodes, and limited sensitivity under 5 mm size,1518 can add to potential false ...... streptavidin-coupled magnetic beads and collected with a magnet. Next, 5 ll of 5750 fg/mL of recombinant DSG3 ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... We would like to thank Sue Samson for her administrative support. REFERENCES 1 2 3 4 5 6 7 8 9 10 11 ...... 4.376 (5-year impact factor: N/A), ranking WJSC as 7 among 24 journals in Cell and Tissue Engineering ...... with plates, screws, nails and wires in surgically treated fractures [4-10] . For example, studies have ...... 2013; 6: 357-363 [PMID: 24222553 DOI: 10.1007/s12178-013-9188-5] Gondalia V, Choi DH, Lee SC, Nam CH ...... fracture and mortality within 5 years after a non-vertebral fracture. Osteoporos Int 2010; 21: 2075-2082 ...
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Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.
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Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
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- ... , Marian University, Indianapolis, IN, United States, 4 Institute of Public Health, Guangzhou Medical ...... University & Guangzhou Center for Disease Control and Prevention, Guangzhou, China, 5 School of Traditional ...... intractable due to a daunting computational hurdle of using gold-standard phylogenetic approaches (4). Routine ...... hypothesis testing problems with H0 : ij = 0 (Figure 1A). Our analysis considered only co-mutations with ...... -CoV-2 genomes were retrieved from GISAID on 25 June 2022. The low coverage sequences (genomes with >5 ...
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Huang, Q., Qiu, H., Bible, Paul W., Huang, Y., Zheng, F., Gu, J., Sun, J., Hao, Y., and Liu, Y.
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Background
Precise public health and clinical interventions for the COVID-19 pandemic has spurred a global rush on SARS-CoV-2 variant tracking, but current approaches to variant tracking are challenged by the flood of viral...
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- ... . 5 4.5 4 Satisfaction Control 3.5 Satisfaction Intervention 3 Task Conflict Control 2.5 Task Conflict ...... Intervention 2 1.5 Relationship Conflict Control 1 Relationship Conflict Intervention 0.5 0 Phase I Phase II ...... conflict management. International Journal of Conflict Management, 12(1), 4-22. De Dreu, C., & Weingart, L ...... -analysis. Journal Of Applied Psychology, 88(4), 741-749. doi:10.1037/00219010.88.4.741 de Wit, F., Greer, L ...... Care, 22(5), 545-548. Haraway, D., & Haraway III, W. (2005). Analysis of the effect of conflict ...
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Conflict can have detrimental effects on team interaction, performance, and member satisfaction, so research on tools and techniques aimed at reducing or resolving conflict is crucial. This study trained the leaders of teams...
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- ... endothelial RhoA-deficient (RhoAf/f Tie2-Cre+) embryos (n = 4). Figure 5. Endothelial RhoA-deficient mice ...... proliferation assay. Cell proliferation of HUVECs was evaluated through the MTT (3-[4, 5-dimethylthiazol-2-yl]-2 ...... stimulated with VEGF (100 ng/ml) (n = 5) (A) and S1P (500 nM) (n = 9) (B) in the presence or absence of C3 ...... toxin (20 ng/ml) treatment. Full-length blots are presented in Supplementary Fig. 4. (C) Representative ...... = 3). Full-length blots are presented in Supplementary Fig. 5. (D) Quantification of VEGF- (100 ng/ ml ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... of America, 4 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial ...... Research, National Institutes of Health, Bethesda, Maryland, United States of America, 5 Department of ...... in Gq and G11 leads oncogenic transformation [3, 4] and is particularly prevalent in the development ...... , keratinocyte cell culture, and transfections All cells were cultured at 37C in the presence of 5% CO2. HEK293Gq ...... room temperature in 5% milk in TBST and then probed with primary antibodies overnight at 4C. Membranes ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... nerve, 4. Common carotid artery, 5. External carotid artery, 6. Sternocleidomastoid, 7. Superior belly ...... 13 302 2. 3. 4. 5. 6. 7. 8. 9. 10. Surgical and Radiologic Anatomy (2023) 45:297302 tumors of the ...... deglutition [3, 5]. Typically, the superior root of the ansa cervicalis is derived from C1 nerve fibers ...... branching off the hypoglossal nerve [5]. Variation in composition and course of the ansa cervicalis is more ...... commonly seen among inferior roots [5]. However, this case report describes * Sumathilatha SakthiVelavan ...
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Dykstra, Chandler, Dwenger, Emma, Parent, Elizabeth, and Sakthi-Velavan, Sumathilatha
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Purpose: This case report aims to explore a rare combination of findings in a cadaver donor: variant ansa cervicalis, vagus (CN X) and hypoglossal (CN XII) nerve fusion, and extracranial hypoglossal neurofibroma.
Background:...
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- ... , although lymphatic invasion is one of the most relevant diagnostic parameters for solid tumors (2, 4, 5 ...... beyond 5 years (9, 10). This is partially attributed to the propensity of HNSCC to metastasize to ...... cultured in EGM-2 (Lonza). All cells were cultured at 37 C in 5% CO2. UMSCC2 and UMSCC17B stable cell ...... February 5, 2014). Immunohistochemistry Tissue arrays containing normal and oral cancer tissues were ...... protein was separated by SDS-PAGE and transferred to polyvinylidene diuoride membrane overnight at 4 C ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... compared to WT NOL7 and 2.6810 -5 and 1.2410-4 compared to the other double mutants N12(-) and N13 ...... organized as a single-stretch monopartite NLS: (K/R) 4-6 , or as a bipartite NLS in which there are two ...... Biology 2010, 11:74 http://www.biomedcentral.com/1471-2121/11/74 Page 4 of 20 Figure 2 NOL7 is composed of ...... PK was evaluated. PS1, 2, 3 and 4 were cloned in frame with the C- terminus of the PK bearing an N ...... nuclear localization signals. Furthermore, the data Page 5 of 20 demonstrate that each NLS is capable of ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... (2019) 12:331 Gorrell et al. BMC Res Notes https://doi.org/10.1186/s13104-019-4367-0 BMC Research ...... morphogenetic proteins (BMPs), which activate SMADs 1, 5, and 8 and play an essential role in embryonic ...... , 3200 Cold Spring Rd, Indianapolis, IN 46222, USA in postnatal tissue homeostasis [4]. Moreover ...... heterotopic ossification [5]. Thus, understanding of the basic mechanisms by which BMP signaling occurs and is ...... for one another [4]. Additionally, the translational potential of these strategies is questionable due ...
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Hum, Julia M. , Totten, Madeline, Gorrell, Ruthann, Schoerning, Laura, Newby, Jordan B., Lowery, Jonathan W., Geyman, Logan J., and Lawless, Warren
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Originally appearing in BMC Research Notes as an open access article under the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)., The bone morphogenetic protein (BMP)...
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- ... (2019) 12:331 Gorrell et al. BMC Res Notes https://doi.org/10.1186/s13104-019-4367-0 BMC Research ...... morphogenetic proteins (BMPs), which activate SMADs 1, 5, and 8 and play an essential role in embryonic ...... , 3200 Cold Spring Rd, Indianapolis, IN 46222, USA in postnatal tissue homeostasis [4]. Moreover ...... heterotopic ossification [5]. Thus, understanding of the basic mechanisms by which BMP signaling occurs and is ...... for one another [4]. Additionally, the translational potential of these strategies is questionable due ...
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Newby, Jordan B., Hum, Julia M., Gorrell, Ruthann, Schoerning, Laura, Lowery, Jonathan W., Lawless, Warren, Totten, Madeline, and Geyman, Logan J.
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The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGF?) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...
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- ... 4/5/2023 - Open Access The impact of C. elegans ceramide glucosyltransferase enzymes on the ...... of glucosylceramides in host-bacterial interaction. 4/5/2023 - Open Access Figure 1. Loss of CGT ...... fed B. subtilis performed worse in response to 100mM PQ at 4/5/2023 - Open Access 1-day old than N2 ...... of 100 mM paraquat in each well. Animals in each well were checked 4/5/2023 - Open Access for ...... administration, resources, writing - review editing, supervision. Reviewed By: Anonymous, Michelle Mondoux 4/5 ...
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Arvin, Chelsey L., Sibila, Zachary, Lamendella, R., Chan, Jason, and Staab, Trisha
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Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt...
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- ... = dBn+1 Y b:si b=d 5 si fb for 0 i n. Note that there are two sets of simplicial structure maps being ...... methods of [4, Theorem 8.8] together with the flowchart from [5, Proposition 2.1] yields the higher order ...... would like to know as much about (S 1 . . . S 1 ) R as possible. Date: February 4, 2020. 2000 ...... 1.1 of [25]), or for R = KU or R = KO [14, 4]. One can also work relative to a fixed commutative ring ...... found in Section 3. In Section 4 we prove that truncated polynomial algebras of the form Q[t]/tm and Z[t ...
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Zou, Foling, Hedenlund, A., Klanderman, Sarah, Richter, B., and Lindenstrauss, A
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Part of special issue: Women in Topology III. Abstract: We develop a spectral sequence for the homotopy groups of Loday constructions with respect to twisted cartesian products in the case where the group involved is discrete....
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- ... SMAD1/5/8; note that SMAD8 is also known as SMAD9) or SMAD2 and SMAD3 (hereafter denoted as SMAD2/3 ...... balance of SMAD1/5/8 and SMAD2/3 establishes an angiogenic switch between activation and resolution phases ...... type 1 alveolar program is promoted by SMAD2/3, but restricted by SMAD1/5/8 (Zhao et al., 2013), during ...... maintenance of epithelial cell polarity, where SMAD1/5/8 restricts the TGFbinduced epithelialmesenchymal ...... transition (Saitoh et al., 2013), and during regulation of skeletal muscle mass, where SMAD1/5/8 and SMAD2/3 ...
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Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.
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Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
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- ... known Broods Chicks EPY 5 2a 4b 4 17 7 14b 13 1 1 1 0 2 1 8 5 0 0 18 64 3 considered the putative father ...... with putative fathers identified, three were the result of extra-pair copulations (5%). Three of 18 ...... , tres (5%) fueron el resultado de copulaciones extra-pareja. Tres de 18 nidadas (7%) presentaron hijos ...... ; Dunn and Cockburn 1996) to nonexistent in the Common Loon (Gavia immer; 0%; Piper et al. SHORT ...... assessed. Freeland et al. (1995) found socially monogamous Willow Ptarmigan to have a low (4%) rate of ...
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The White-tailed Ptarmigan (Lagopus leucurus) is one of the few socially monogamous species within the highly polygynous grouse subfamily (Tetraoninae). I found White-tailed Ptarmigan in Glacier National Park, Montana,...
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- ... %) 0.6 mg/kg: 4 (80%) 1.0 mg/kg: 6 (86%) AEs related to burosumab: 5 (28%) 0.3 mg/kg: 3 (50%) 0.6 mg/kg ...... Adult N = 38 IV N = 22 Burosumab, N = 17 Placebo, N = 5 SC, N = 16 Burosumab, N = 12 Placebo, N = 4 ...... AEs: 13 (100%) AEs related to burosumab: 5 (38%) AEs leading to discontinuation or death: 0 Most ...... . Conflicts of Interest: The authors declare no conflict of interest. References 1. 2. 3. 4. 5. 6. 7. 8. 9 ...... , Pathophysiology and Pharmacology Jon Vincze 1,2 , Brian W. Skinner 3 , Katherine A. Tucker 4 , Kory A. Conaway 1,2 ...
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Vincze, Jon, Hum, Julia, Conaway, Kory, Skinner, Brian, Tucker, Katherine, and Lowery, Jonathan
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The authors present a stereotypical case presentation of X-linked hypophosphatemia (XLH) and provide a review of the pathophysiology and related pharmacology of this condition, primarily focusing on the FDA-approved medication...
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- ... -century pope, who in fact never 3 4 5 6 7 8 9 (Austin 1990, p. 19). (Canales 2002, pp. 107, 111). (Austin ...... (2019). Religions 2020, 11, 417 4 of 13 5. The Current Approach to Adolescent Confirmation There are ...... Confirmation with adolescents. Sawyers eight principles are as follows: 1. 2. 3. 4. 5. 6. 7. 8. The Process ...... through Friday or an evening session could span from 5:00-8:00PM Monday through Friday. Ideally, this ...... for God.4 3. The Early Developments of Confirmation The term seal (sphragis in Greek) was used in the ...
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This article will briefly address the origins of confirmation and the current approaches to adolescent confirmation. Moreover, the article discusses the two predominant models of confirmation in the Catholic Church in the...
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- ... selected for this study are given in Table 1. Five seedlings (4 - 5 years old) were randomly selected for ...... : cluster 1: 41 clones; cluster 2:29 clones; cluster 3: 29 clones; cluster 4: 10 clones; cluster 5: two ...... 23 16 20 17 76 -Proteobacteria 11 20 16 17 64 -Proteobacteria 9 13 12 15 49 -Proteobacteria 3 7 4 5 ...... 19 Uncultivated Proteobacteria 4 3 2 3 12 Acidobacteria 12 16 13 16 57 Actinobacteria 5 5 7 3 20 CFB ...... group 5 2 3 5 15 Firmicutes 6 8 7 5 26 Planctomycetes 3 8 4 7 22 Verrucomicrobia 5 3 4 3 15 Unclassified ...
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The goal of this research was to determine the effects of the growth of invasive plant Amur Honeysuckle (Lonicera maackii) on the rhizosphere bacterial community composition, and diversity in an urban wetland forest ecosystem....
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- ... * * 15 WT + Vehicle MFS + Ang II 10 * 5 0 * 25 FPKM of Fibrillin-1 Marfan syndrome (MFS) represents a ...... 0.0 0 W T * 1.5 W T+ A 0.0 * W T 0.5 1 Total p38 (Normalized to WT) 1.0 2 ng II 50 m 1.5 * W T+ A * 3 ...... <0.05 SAE WT + Veh WT + Ang II MFS + Veh MFS + Ang II 3.0 2.5 2.0 1.5 1.0 10 14 28 Conclusions 5 * This ...... surgery 10 TGFB1 TGFB1 TGFB2 TGFB2 TGFB3 TGFB3 3.5 0 Left: Fragments per kb of transcript per million ...
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Turek, JW, Qian, L, Westergaard, NM, Cavanaugh, Nicholas B., and Dyle, MC
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Marfan syndrome (MFS) represents a genetic disorder with ranging clinical presentation, most notably ascending aortic aneurysms. There has been extensive research to elucidate the mechanistic biochemistry of this disease. In...
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- ... Zhang 2 , Paul W. Bible 3 , Qiaoxing Liang 4 , Fangfang Zheng 5 , Ying Wang 1 , Yuantao Hao 1* and Yu ...... Sciences, Marian University, Indianapolis, IN, United States, 4 State Key Laboratory of Ophthalmology ...... , Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China, 5 School of Traditional Chinese ...... genomes with > 5% Ns). Consequently, a total of 5,043,950 genomes were collected. Because significant ...... set to be the average plus 5 standard deviations. MATERIALS AND METHODS Calculation and Filtration of ...
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Wang, Y., Zhang, Q., Liu, Y., Liang, Q., Zheng, F., Hao, Y., Bible, Paul, W., and Huang, Q.
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Early detection of SARS-CoV-2 variants enables timely tracking of clinically important strains in order to inform the public health response. Current subtype-based variant surveillance depending on prior subtype assignment...
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- ... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... binding (Figure 4, lane 5). Finally, to demonstrate that this interaction was mRNA-specic and not a random ...... GFP or NOL7 were untreated or transcriptionally inhibited with 5 mg/ml a-amanitin for 4 h. After ...... . 44 West S, Gromak N, Proudfoot NJ. Human 5 --4 3 exonuclease Xrn2 promotes transcription termination ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... D 40 30 5-23-19 Primary Root Growth OPS Col-0 Root Length (cm) B ops-4 10 b b 5 10 0 0 Col-0 ops-3 ...... C D FRK1 5 Expression Relative to C ACTIN a a 4 60 PR1 a a 2 b 20 b 10 5 c 1 b 0 15 3 a 40 Hours 3 ...... ops-4 ops-3 WRKY33 1 ol C 00 ol -0 min C 30 ol m i C 06 n ol 0 m -0 18 in op 0 m sin op 3 0 m sin 3 3 ...... , Marian University, Department of Biology, 3200 Cold 4 Spring Road, Indianapolis, IN 46222, USA. 5 Email ...... detection (8, 23). Col-0 and both independent ops- 147 3 and ops-4 mutant alleles were grown in liquid media ...
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Stegemann, Katherine A., Collins, Carina, Melena, I., King, C., and Greenwood, K.
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Phloem is a critical tissue that transports photosynthates and extracellular signals in vascular plants. Although a functional phloem is necessary for plant health, it is also an ideal environment for pathogens to access host...
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- ... ) *** *** 20 15 10 5 0 S. consobrinus S. u. hyacinthinus S. u. undulatus F I G U R E 4 Behavioral differences ...... rules of use; OA articles are governed by the applicable Creative Commons License 4 5 2.2 | Scoring ...... License 6 3 4 7 Headbob 1 Adjustment S. u. undulatus 0 Can2 (9.9%) 2 Chem 1 S. u. hyacinthinus S ...... . consobrinus 2 Travel 3 2 1 0 1 2 3 4 Can1 (90.1%) F I G U R E 3 Canonical discriminant plot for the ...... displays / hour ROMERO-DIAZ et al. 20 15 10 5 0 S. consobrinus S. u. hyacinthinus S. u. undulatus (c ...
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Romero-Diaz, C., Wetherell, B., Ury, D., Reuter, M., Pruett, J., Martins, E., and Ossip-Drahos, Alison G.
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Animals evolve in complex selective regimes, where a suite of different factors can shape signal use. We might predict that more closely related species will exhibit more similar behavior than those more distantly related;...
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Preventing Pandemics and Containing Disease: A Proposed Symptoms-Based Syndromic Surveillance System
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- ... systems in place to track increase in existing as well as novel disease incidence [4-8] (Table 1); however ...... professionals) to reduce cholera cases from 400 to 0 in three weeks (Sofala, Africa, 2019) A conglomeration of ...... structures [3,15]. The third problem with current methods is fragmented communication and integration [4-8 ...... , delaying, and avoiding routine health care services: patient perspectives. Am j health promot 28(5): 286 ...... potential COVID19. Nat med 26(7): 1037-1040. 4. (2020) Centers for Disease Control and Prevention. FAQ ...
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Mulye, Minal, Abraham, Benjamin M., Schmid, Aaron, Khan, Israt, and Akbar, Samina
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Background: Due to globalization, spread of a pandemic is inevitable as we have seen with COVID-19. Further, increased ease of travel increases the potential and frequency of pandemics. Hence, it is imperative to find solutions...
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- ... tetratricopeptide repeat 1 (Ifit1), interferon-stimulated gene 15 (Isg15), MX dynamin like GTPase 1 (Mx1) and 2-5 ...... antagonized by the antiinflammatory cytokines interleukin-4 (IL-4) and IL-13, which promote an alternative ...... increase in t=0 versus 48 h; Fig. 1B), and this was mirrored at the protein level (Fig. 1C). This differs ...... expression at 24 h post-stimulus (Fig. 1F). However, IFN and LPS co-treatment stimulated a >4-fold increase ...... manner, similar to PTH-stimulated nuclear translocation of CITED1 in osteoblasts. 4 Journal of Cell ...
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Subramani, A., Hite, M., Garcia, S., Maxwell, J., Kondee, H., Millican, G., McClelland, Erin E., Seipelt-Thiemann, R., and Nelson, D.
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Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and...
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- ... cardiovascular disease increases the risk of severe COVID-19 disease and death [4, 5], but does COVID-19 ...... . [27] 100% 0% 40% 100% 100% 10 (mean) 20 Grimaud et al. [118] 11% 71% 4% 96 ...... cardiovascular system, Nature Reviews. Cardiology, vol. 17, no. 5, pp. 259-260, 2020. [4] E. Driggin, M. V ...... and induce microcirculatory disorders in the heart [26] (4) Damage Mediated by a Systemic Inammatory ...... ARDS, coagulopathy, and COVID-19-related cardiovascular complications [31] (5) Vessel Occlusion as a ...
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Akella, K., Pareddy, A., Petrovic, M., Schmid, A., and Sakthi Velavan, Sumathilatha
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COVID-19 was primarily identified as a respiratory illness, but reports of patients presenting initially with cardiovascular complaints are rapidly emerging. Many patients also develop cardiovascular complications during and...
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- ... ) - 12( 3-4 ) 5 ...... ( !"# $ % &' %(')"#*+,! -./00 /1/2 56 ...... !"#!$$!%"&#' ()* +(*,,- .- ),, * . / - 0 ...... ( ! " # $ % # & $' ( ) (# # $ ) (* !#+ ## ,-!.* /#$$# $#/ # (((# / $ ! #$ % #0/ !# 1% #* 2'# ARTS EDUCATION POLICY REVIEW https://doi.org/10.1080 ...... reveals ulterior motives that exist in education. In chapter 5, he addresses current problems in education ...
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Goodman, Shawn L. (Marian University), Ellerbe, Amanda E., and Arnold, Melissa A.
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In his book, Music Education in an Age of Virtuality and Post-Truth, Woodford presents a welcomed discussion of the aims of music education in a time of political unrest. This timely text is needed due to the stresses of the...
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- ... ) reasons for doing science, 4) nature of science, and 5) interconnectivity rating. Rubric dimension 6 is ...... NOS are evaluated throughout the rubric, including dimensions 1, 3, 4, and 5. For example, the ...... ) intermediate, 4) proficient, or 5) expert. Dimensions 2 through 4 are evaluated based on rubric guidelines ...... . 1 = nave; 2 = novice; 3 = intermediate; 4 = proficient; and 5 = expert. The total possible rating ...... change was made to increase the clarity and conciseness of the prompt. Prompt section 4 accounted for the ...
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The scientific process is nonlinear, unpredictable, and ongoing. Assessing the nature of science is difficult with methods that rely on Likert-scale or multiple-choice questions. This study evaluated conceptions about the...
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- ... 0 103 dorsal tongue Lymph nodes invaded (%) Cumulative population doubling 5 0 102 200 CXCR4 E 4 D ...... cells 20 5 shCXCR4 0 28 Time (days) 50m 500m K shControl 21 H Normal LN 500m shControl shCXCR4 14 ...... 5 0 shControl 1 0.0004 0.0003 0.0002 0.0001 0.0000 shControl J shControl shRictor shRictor 40 20 0 1 ...... 2 H 0.3 0.2 shRaptor 1 shRaptor 2 0.1 25 20 15 10 ** *** 5 0 0.0 shControl 1 2 shRaptor shRictor ...... Health, Bethesda, Maryland Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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- ... ) 5 Subheading 2 12,787 (97.5) 6 Subheading 3 7555 (57.6) 7 Subheading 4 2984 (22.7) 8 Subheading 5 95 ...... is derived from scientific societies based in the United States targeting medical students in the 4 ...... General Internal Medicine (CDIMSHIM) [14], have content that is usually covered in years 3 and 4 of ...... freely accessible on their website [5]. A digital pdf copy had been created for the Association of ...... Education of Anesthesia 2009 Behavioral Sciences ADMSEP [4] Association of Directors of Medical Student ...
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BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common
gold standard
resource used building curricula are medical objectives suggested by national...- Tipo:
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- ... ) 5 Subheading 2 12,787 (97.5) 6 Subheading 3 7555 (57.6) 7 Subheading 4 2984 (22.7) 8 Subheading 5 95 ...... is derived from scientific societies based in the United States targeting medical students in the 4 ...... General Internal Medicine (CDIMSHIM) [14], have content that is usually covered in years 3 and 4 of ...... freely accessible on their website [5]. A digital pdf copy had been created for the Association of ...... Education of Anesthesia 2009 Behavioral Sciences ADMSEP [4] Association of Directors of Medical Student ...
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- Descrição:
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common
gold standard
resource used building curricula are medical objectives suggested by national...- Tipo:
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- ... . Lowery 1,2,3,5,8,9, * 1 2 3 4 5 6 7 8 9 * Citation: Marciano, C.L.; Hiland, T.A.; Jackson, K.L.; Street ...... ) ligand 5 (CCL5) and increased soft tissue levels of Interleukin (IL)-4, which are pro-inflammatory and ...... detected on the membrane including IL-4, Granulo10/CXCL-10, CXCL-5/Lipopolysaccharide-Induced CXCarray ...... . 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. Lucas, J.W.; Connor, E.M.; Bose, J. Back, Lower Limb ...... /CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain Carmela L. Marciano 1,2, , Taylor ...
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Marciano, Carmela L., Hiland, Taylor A., Chu, TM, Kang, Kyung S., Lowery, Jonathan W., Jackson, Krista L., Street, Sierra, Maris, Carson, Ehrsam, Andrew, Hum, Julia M. , and Loghmani, M
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Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive...
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- ... , yet substantial, on certain components of the GDP. 8% 6% 4% 2% 0% -2% -4% -6% 2007 2008 EU 2009 US ...... 30% 25% 20% 15% 10% 5% 0% -5% -10% -15% -20% 2007 2008 2009 5 of 22 5 of 22 2010 2011 2012 2013 GDP ...... , Chile, EU, EU, and and US. US. Figure 20% 20% 15% 15% 10% 10% 5% 5% 0% 0% -5% -5% -10% -10% -15% -15 ...... + 3 Lag_hk + 4 Effective_spread + 5 Zero_return _days +6 Percentage_bonds + 7 Fair_value + 8 ...... examination of the possibility that institutional managers, retail investors, 4 5 Durbin-h test indicates the ...
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The study examines evidence for the transmission of the US and EU financial crises via investor holdings into the Chilean stock market following two global financial crises, in 2008 and 2011. The study modified the models of...
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Panichpisal, K, Schwartz, B G., Warner, D S., Babygirija, R, Biddick, L; , Rovin, R A., Kassam, A B, Sajjad, R., and Chohan, Adil OMS-2
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BACKGROUND: Patients with an acute ischemic stroke (AIS) following cardiac catheterization (CC) generally do not receive intravenous thrombolysis [intravenous tissue plasminogen activator (IV-tPA)] as it is contraindicated due...
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- ... bicomodules in Section 5, which has been 4 under-documented in the literature thus far. In Section 6, we ...... . Contents 1. Introduction 2. The universal cotrace 3. Bicategories of bicomodules 4. CoHochschild homology ...... as a shadow 5. Duality 6. Traces 7. Morita-Takeuchi invariance Appendix A. Homotopy theory of ...... , L(f ). If L(f ) 6= 0, then f is has at least one fixed point [Lef26, Lef37]. The definition of the ...... defines a bicategorical shadow, is proved in Section 4. We then explore the notion of duality in ...
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We provide traces for coHochschild homology, dualizing the Hattori-Stallings trace. Considering the trace of the identity, we define traces between coHochschild homology and certain K-theories of coalgebras. We employ...
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- ... 3 ** 4 TLE3 0 Moc 2 Myf5 5 MCK0.8-luc 3 2 ** 1 Myogenin TLE3 MRF4 F 1.6 MCK0.8-luc 1.4 4 0 Moc 1 ...... TLE3 Moc 0 ** 3 TLE3 5 C 6 TLE3 10 MG185-luc Moc 15 4 Moc 20 Moc Relative expression 25 B Moc MG185-luc ...... expression 5 4 3 * 2 1 0 MyoD (50 ng): 1 2 + 6 + + + + 3+ 4+ 5 7 8 TLE3 (50 ng ...... growth medium (GM) for 7 days (7d) after isolation. CF, mice were sacrificed 0 (Intact), 1, 3, 5, 7, 10 ...... ** 1.2 1 0.8 0.6 0.4 0.2 0 Moc 6 ** 2 Moc 8 3 0 Relative expression 10 E Moc 12 4 Myogenin Relative ...
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Addison, William N, Yoda, Tetsuya, Rosen, Vicki, Nakatomi, Mitsushiro, Nakatomi, Chihiro, Urata, Mariko, Hitomi, Suzuro, Osawa, Kenji;, Jimi, Eijiro, Sato, Tsuyoshi, Ono, Yusuke, Kokabu, Shoichiro, Matsubara, Takuma, Hudnall, Aaron M, and Lowery, Jonathan W.
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Satellite cells are skeletal muscle stem cells that provide myonuclei for postnatal muscle growth, maintenance, and repair/regeneration in adults. Normally, satellite cells are mitotically quiescent, but they are activated in...
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- ... show expression of the basal marker keratin 5 (K5, red), and differentiation markers keratin 4 (K4) for ...... , La Jolla, CA, USA 4.Oral Immunity and Inflammation Unit, National Institute of Dental and ...... Craniofacial Research, Bethesda, MD, USA 5.Biodata Mining and Discovery Section, National Institute of ...... four systematic phases: hemostasis, inflammation, proliferation and remodeling (5). The molecular ...... ). Clinical screening was performed (Day 0) followed by baseline biopsies to create paired identical wounds in ...
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Onaitis, Mark W., Asselin-Labat, Marie-Liesse, Gutkind, J. S., Uchiyama, Akihiko, Callejas-Valera, Juan Luis, Abusleme, Loreto, Molinolo, Alfredo A., Edwards, Dean, Moutsopoulos, Niki M., Iglesias-Bartolome, Ramiro, Morasso, Maria I., Doci, ColleenL., and Brooks, Stephen R.
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Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We...
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