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- ... Research ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral ...... with preventive strategies. Using the 4-nitroquinoline 1-oxide (4-NQO) mouse model, we sought to define ...... angiogenesis can slow/delay the development of HNSCC. We determined that 8 weeks of 100 g/mL 4-NQO in the ...... suggest that our refinement of the 4-NQO model allows for the investigation of the histologic, molecular ...... rates, approximately 400,000 cases of head and led Slaughter et al. (4) to propose the concept of field ...
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Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen
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Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...
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- ... (69) 21 (25) 1 (1.2) 4 (4.8) 48 (82.8) 10 (17.2) 0 (0) 0 (0) 52 (70.3) 16 (21.6) 4 (5.4) 2 (2.7) 26.3 ...... % 2.9% 9.6% 0 (0) 46 (82.1) 4 (7.1) 1 (1.8) 5 (8.9) 3 (3.6) 66 (78.6) 1 (1.2) 4 (4.8) 9 (10.7) 1 (1.7 ...... ) 43 (74.1) 4 (6.9) 3 (5.2) 7 (12.1) 6 (8.1) 60 (81.1) 3 (4.1) 0 (0) 5 (6.8) 0.3% 71% 27.8% 0% 1% 0 (0 ...... ) 17.8% 9.7% 1.7% 2.6% 5 (8.9) 4 (7.1) 0 (0) 3 (5.4) 23 (27.4) 11 (13.1) 3 (3.6) 2 (2.4) 10 (17.2) 6 ...... ) 27 (48.2) 12 (14.6) 34 (41.5) 1 (1.2) 35 (42.7) 5 (8.6) 21 (36.2) 2 (3.5) 30 (51.7) 6 (8.1) 17 (23) 4 ...
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Zahl, Sarah, Hum, Julia M., Jackson, Krista L., Griffin, Nicole, Lowery, Jonathan W., Nick, Benjamin, Herber, Jake, Hamby, T., Baumann, Michael, and Ogunbekun, Oladipupo
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Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and life-long learning skills, greater appreciation for evidence-based...
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- ... perform cannulation of the IJV [21, 67, 115]. However, considering the highly variable nature of the IJV ...... ]. There is no 4 gold standard for the diagnosis of IJV pathologies, but a combination of various imaging ...... included bifurcation (4), duplication (14), fenestration (16), trifurcation (1), and posterior tributary (5 ...... cannulations and all of them were cannulated into the left IJV or the axillary vein [4, 61, 79, 96]. A 55-year ...... patients with IJV agenesis [4]. The agenesis of IJV may be associated with malformations in the ...
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Kosnik, Natalie, Kowalski, Taylor, Lorenz, Lorraine, Valacer, Mercedes, and Sakthi-Velavan, Sumathilatha
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The internal jugular veins (IJV) are the primary venous outflow channels of the head and neck. The IJV is of clinical interest since it is often used for central venous access. This literature aims at presenting an overview of...
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- ... 3: C02 (a), 4: C02 (b), 6: C20 , 7: C60 (a), 8: C18 0 , and 9: C1 ]. 0.32%, respectively (Table I ...... : 11 October 2022 Published Online: 4 November 2022 Hansika I. Sirikumara,1,a) Wilson Rativa-Parada,2 ...... composites.4 Graphene, a carbon allotrope, is used as the reinforcement in this study. In the process of ...... mixer (SPEX corp.) for 4 h, with 1 wt. % of stearic acid [CH3 (CH2 )16COOH] obtained from Sigma-Aldrich ...... : bulk modulus). Configuration C00 C01 C10 C20 C02 (a) C02 (b) C11 C60 (a) C60 (b) C18 0 Composition a ...
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Jayasekera, T., Nilufar, S., Karunanithy, R., Sivakumar, P., Rativa-Parada, W., and Sirikumara, Hansika
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Embedding carbon in metals has long been known to enhance the mechanical properties of metal carbon composites. We report the possibility of growing Al–C composites by the hot isostatic pressing method, with carbon embedded...
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- ... (4.) The 2009 map of canal system NMP EcoLab 2 showing the relationship between beaver-cut stumps ...... average width of the canals increased 21% and the average depth of the canals increased 27% within that ...... % 100.00% 100.00% 61.04% 80.33% 0 0 6 6 6 6 6 6 6 6 83 261 206 451 130 178 N/A 421 N/A 932 54 30 58 96 154 ...... . 1923. Observations on a Montana beaver canal. Journal of Mammalogy 4:92103. Brenner, F.J. 1962. Foods ...
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Kot, Amanda, Nicholson, Jody, Black, Matt, Abbott, Matthew J., Wilson, Jon, Thomas, Adam, Schaffer, Benton, Fultz, Brandon, Benson, David P., and Burrows, Mallory
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Castor canadensis Kuhl (North American beavers) are central place foragers who
collect woody plants and building materials from their surroundings and return to a main body of water containing a lodge or food cache. It has...- Type:
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- ... of the plate (37 C, 5% CO2, 0% O2) for 4 hours. After 4 hours, 100 L of detergent (0.01N HCl with 10 ...... lower the blood glucose levels by increasing GLUT-4 transporter mediated downstream signaling pathways ...... stimulates glucose uptake by enhancing mobilization of endocytosed GLUT-4 transporters to the cell membrane ...... (Shin & Koo, 2021). However, whether relative contributions of GLUT-1 and GLUT-4 transporters are ...... -GLUT-4 pathway. Several of these possibilities could be investigated in the future. Methods Bitter ...
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Kakuturu, Abhinav , Choi, Heeyun , Noe, Leah G., Scherer, Brianna N., Sharma, B., Khambu, B., and Bhetwal, Bhupal P.
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Breast cancer is one of the most commonly diagnosed cancers among women, however the complete cure for metastatic breast cancer is lacking due to poor prognosis. There has been an increasing trend of dietary modifications...
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BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.
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- ... and OCY Using Velocigene technology (21), a BMP3-null mouse was generated where the first exon ...... (BMP3 LacZ knock-in). To examine skeletal expression of BMP3, we analyzed heterozygous mice at 4 wk of ...... agreement with profiling data from Paic et al. (21) who reported that BMP3 as well as Acvr2b transcripts ...... Endocrinol, January 2012, 26(1):8794 FIG. 1. OBL and OCY express BMP3. Tibia from BMP3 4-wk-old LacZ knock-in ...... induced by BMP4. B and C, W20-17 cells were cotransfected with 0, 30, 60, or 90 ng BMP3 expression vector ...
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Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
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Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
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- ... -GTAGAGTATTTT TAGTGGGGTTTATT-30 and 50 -AAACTACACCA TAACCCA-30 ) (Figure 4). The PCR program used was 941C for ...... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... with 293T controls. Po2 104; Fig. 1B). Four of these cell lines, Ca Ski, ME-180, SiHa, and SW756 ...... , demonstrated consistently downregulated NOL7 mRNA and protein. Interestingly, 5 of the 13 (40%) cell lines, C-4 ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... ), Tandem Repeats Finder v4.09 (Benson 1999) or Page 4/21 LTR_FINDER v1.06 (Xu et al. 2007). Gene ...... were annotated by homology to known proteins, domains or transcripts (Supplementary Page 7/21 Table 4 ...... indicate inversion. Page 17/21 Figure 4 LTR insertion analysis. A. LTR insertion times of the four sorghum ...... . The density graph of LTR insertion times of 4 sorghum species for gypsy superfamily Page 18/21 Figure ...... -1777118/v1 Page 1/21 License: This work is licensed under a Creative Commons Attribution 4.0 ...
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Bible, Paul, W., Wang, L., Jin, P., Zheng, J., Wang, Y., Zhan, Q., Li, J., Liu, Y., and Tu, W.
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Sudangrass [ Sorghum sudanense (Piper) Stapf] is a hybrid between grain sorghum and its wild relative S. bicolor ssp. verticilliflorum and is grown as a forage crop due to its high biomass production and low dhurrin content...
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Providing safe and effective care is identified by the Quality and Safety Education for Nurses (QSEN) guidelines as an essential competency (QSEN, www.qsen.org). First semester nursing students are challenged to evaluate their...
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- ... activin and BMP-4 signaling in Xenopus embryos. Developmental biology 285: 156168. 21. Hino J, Nishimatsu ...... -eutherian animal (0/136). We also identified multiple conserved transcription factor binding sites in the ...... ligands BMP2/4 and BMP5/6/7 (Dpp and Gbb in Drosophila, respectively) share dramatic identity, BMP3 is ...... TGF-b/Activin and BMP ligands [9,10] and shares only 40% amino acid identity with the ancestral BMP2/4 ...... blocks of $80% identity: a proximal one spanning from positions 21 to 2806 and a distal one spanning ...
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The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...
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- ... Change 8 3 6 +M ur y In j t ro on +M ur y In j C y In ju r t ro y 0 In ju r 0 FR 2 l 1 FR 4 l b 2 on FR ...... on C l 0 l 0 tro Fold Change 6 Fig. 4 Graphs displaying the average fold change of each run between ...... expression [4]. Standley and Meltzer did not use the CBA in any of their studies. This experiment attempts to ...... /IL-1F2, IL1ra/IL-1F3, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 p70, IL-13, IL-16, IL-17A, IL-17E ...... , IL18/IL-1F4, IL-21, IL-27, IL-32, MIF, Serpin E1/PAI-1, TNF-, and TREM-1 using the Proteome Profiler ...
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This experiment analyzes three different techniques used in literature to detect cytokine release from cells in vitro: the Human Cytokine Array (HCA) by R&D Systems, the BD Cytometric Bead Array (CBA) assay, and protein...
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- ... crystallinity that can impact potency [21]. 4. Materials and Methods 4.1. ELDI-MS A Thermo Fisher Scientific LTQ ...... imaging; MSI; ELDI; agglomeration; crystallinity; pharmaceuticals Received: 31 December 2020 Accepted: 21 ...... enabling tablet formulation [4]. Crystallinity can be an issue for BCS Class II/IV drugs if the active drug ...... acetaminophen tablets [4]. ELDI is similar to MALDI; however, ionization via an applied matrix is replaced by ...... done similar to our previous work. Acetaminophen tablets with 0, 2.5, 5, and 10% crystalline API were ...
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Khan, Salah, McVey, Patrick, Taulbee-Cotton, Brynne, Webster, G, Van Meter, Mariann, Hubbard, Nathan, Dimmitt, Nathan, and Green, Adam
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Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as...
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- ... human breast cancer: an update. Surg Oncol 2011;20(4):e195206. 21. Patel V, Hood BL, Molinolo AA, Lee NH ...... epithelium and cancer lesions.21 DSG3 is a transmembrane glycoprotein involved in cell-to-cell adhesion that ...... protein standards or 4 ll tissue extract were diluted 1:6000 in RIPA buffer and added to the bioconjugates ...... lysates used for Western blot analysis and microuidic immunoarrays were made from primary tumors (n = 4 ...... HNSCC progression, we noted that DSG3 was highly expressed in normal oral mucosa and HNSCC lesions.21 To ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... Inc. All rights reserved. Received: March 21, 2019 Peer-review started: March 22, 2019 First decision ...... with plates, screws, nails and wires in surgically treated fractures [4-10] . For example, studies have ...... between the bone fragments[21]. Subsequently, the chondrocytes become hypertrophic and undergo ...... activation of SIRT1 improves the survival of aged MSCs upon transplantation[21] and also significantly ...... We would like to thank Sue Samson for her administrative support. REFERENCES 1 2 3 4 5 6 7 8 9 10 11 ...
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Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.
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Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
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- ... reality. Eurosurveillance. (2017) 22:2 4. doi: 10.2807/1560-7917.ES.2017.22.13.30494 21. Hadfield J ...... , Marian University, Indianapolis, IN, United States, 4 Institute of Public Health, Guangzhou Medical ...... intractable due to a daunting computational hurdle of using gold-standard phylogenetic approaches (4). Routine ...... hypothesis testing problems with H0 : ij = 0 (Figure 1A). Our analysis considered only co-mutations with ...... k X mi N mi ij s e / e (2) mj k s mj s s=0 for max mi + mj N, 0 k min(mi , mj ) and the same ...
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Huang, Q., Qiu, H., Bible, Paul W., Huang, Y., Zheng, F., Gu, J., Sun, J., Hao, Y., and Liu, Y.
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Background
Precise public health and clinical interventions for the COVID-19 pandemic has spurred a global rush on SARS-CoV-2 variant tracking, but current approaches to variant tracking are challenged by the flood of viral...
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- ... . Journal of Management, 21(4), 691-710. doi:10.1016/0149-2063(95)90006-3 Rai, H. (2013). The measurement of ...... gathering. Among the participants, 21 of the participants were Medical/Dental Education Preparatory Program ...... . 5 4.5 4 Satisfaction Control 3.5 Satisfaction Intervention 3 Task Conflict Control 2.5 Task Conflict ...... Intervention 2 1.5 Relationship Conflict Control 1 Relationship Conflict Intervention 0.5 0 Phase I Phase II ...... conflict management. International Journal of Conflict Management, 12(1), 4-22. De Dreu, C., & Weingart, L ...
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Conflict can have detrimental effects on team interaction, performance, and member satisfaction, so research on tools and techniques aimed at reducing or resolving conflict is crucial. This study trained the leaders of teams...
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- ... toxin (20 ng/ml) treatment. Full-length blots are presented in Supplementary Fig. 4. (C) Representative ...... the VE-cadherin Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 4 ...... ). After 4-hydroxytamoxifen (4-OHT) administration during P2-P5 (Fig. 6B), as previously described36, we ...... repeated the analysis in P9 retinas, after 4-hydroxytamoxifen (4-OHT) administration during P2-P6.5 (Fig ...... / www.nature.com/scientificreports Figure 4. Endothelial RhoA-deficient embryos present no gross vascular ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... of America, 4 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial ...... in Gq and G11 leads oncogenic transformation [3, 4] and is particularly prevalent in the development ...... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... . Then EdU (10 M) was incorporated for 4 h and cells were fixed in a 4% paraformaldehide/PBS solution ...... Axio PLOS ONE | https://doi.org/10.1371/journal.pone.0173692 March 16, 2017 4 / 18 Epidermal loss of ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... nerve, 4. Common carotid artery, 5. External carotid artery, 6. Sternocleidomastoid, 7. Superior belly ...... collagen fibers (2), scattered fibroblast (3), and venules (4) was found to arise from the vagus nerve on ...... foramina of the area vertebralis of the occipital region [4]. In adults, the canal is separated from the ...... 13 302 2. 3. 4. 5. 6. 7. 8. 9. 10. Surgical and Radiologic Anatomy (2023) 45:297302 tumors of the ...... Health Sci Res 4:2931. https://doi.org/10.4103/2141-9248.131705 Lum SG, Baki MM, Yunus MR (2021) A rare ...
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Dykstra, Chandler, Dwenger, Emma, Parent, Elizabeth, and Sakthi-Velavan, Sumathilatha
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Purpose: This case report aims to explore a rare combination of findings in a cadaver donor: variant ansa cervicalis, vagus (CN X) and hypoglossal (CN XII) nerve fusion, and extracranial hypoglossal neurofibroma.
Background:...
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- ... , although lymphatic invasion is one of the most relevant diagnostic parameters for solid tumors (2, 4, 5 ...... NRP2 (21). However, the relevance of SEMA3F expression in cancers lacking NRP2 has not been ...... protein was separated by SDS-PAGE and transferred to polyvinylidene diuoride membrane overnight at 4 C ...... antibodies overnight at 4 C. Membranes were washed four times in Trisbuffered saline 1% Tween-20, probed ...... substrate (Millipore). Immunouorescence For LECs and normal oral keratinocytes (NOK), cells were xed with 4 ...
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Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
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Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
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- ... organized as a single-stretch monopartite NLS: (K/R) 4-6 , or as a bipartite NLS in which there are two ...... Biology 2010, 11:74 http://www.biomedcentral.com/1471-2121/11/74 Page 4 of 20 Figure 2 NOL7 is composed of ...... PK was evaluated. PS1, 2, 3 and 4 were cloned in frame with the C- terminus of the PK bearing an N ...... -WT PK PS1 C PS1 PS2 PS2 PS3 Np Np PS4 DAPI a-Myc Merge Figure 4 NOL7 contains three NLSs that are ...... compared to WT NOL7 and 2.6810 -5 and 1.2410-4 compared to the other double mutants N12(-) and N13 ...
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BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
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- ... (2019) 12:331 Gorrell et al. BMC Res Notes https://doi.org/10.1186/s13104-019-4367-0 BMC Research ...... , 3200 Cold Spring Rd, Indianapolis, IN 46222, USA in postnatal tissue homeostasis [4]. Moreover ...... for one another [4]. Additionally, the translational potential of these strategies is questionable due ...... Systems 892143) was added to the beads and incubated overnight at 4 C with gentle rocking. The supernatant ...... day 0; on day 1 the medium was exchanged to DMEM containing 0.5% FBS. After approximately 24 h of ...
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Hum, Julia M. , Totten, Madeline, Gorrell, Ruthann, Schoerning, Laura, Newby, Jordan B., Lowery, Jonathan W., Geyman, Logan J., and Lawless, Warren
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Originally appearing in BMC Research Notes as an open access article under the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)., The bone morphogenetic protein (BMP)...
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- ... (2019) 12:331 Gorrell et al. BMC Res Notes https://doi.org/10.1186/s13104-019-4367-0 BMC Research ...... , 3200 Cold Spring Rd, Indianapolis, IN 46222, USA in postnatal tissue homeostasis [4]. Moreover ...... for one another [4]. Additionally, the translational potential of these strategies is questionable due ...... Systems 892143) was added to the beads and incubated overnight at 4 C with gentle rocking. The supernatant ...... day 0; on day 1 the medium was exchanged to DMEM containing 0.5% FBS. After approximately 24 h of ...
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Newby, Jordan B., Hum, Julia M., Gorrell, Ruthann, Schoerning, Laura, Lowery, Jonathan W., Lawless, Warren, Totten, Madeline, and Geyman, Logan J.
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The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGF?) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...
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- ... 4/5/2023 - Open Access The impact of C. elegans ceramide glucosyltransferase enzymes on the ...... of glucosylceramides in host-bacterial interaction. 4/5/2023 - Open Access Figure 1. Loss of CGT ...... . subtilis (3A1T; blue). Worms were tracked for lifespan starting at L4 stage (day 0) and scored every 2 days ...... fed B. subtilis performed worse in response to 100mM PQ at 4/5/2023 - Open Access 1-day old than N2 ...... the R (version 4.0) statistical package survival (version 3.5-0) and survminer (version 0.4.9). Acute ...
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Arvin, Chelsey L., Sibila, Zachary, Lamendella, R., Chan, Jason, and Staab, Trisha
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Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt...
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- ... [21]: THH[n],k (A; M ) = HH (A; M ) if A is k-flat [4, Proposition 7.2]. Given a commutative ring A ...... would like to know as much about (S 1 . . . S 1 ) R as possible. Date: February 4, 2020. 2000 ...... 1.1 of [25]), or for R = KU or R = KO [14, 4]. One can also work relative to a fixed commutative ring ...... found in Section 3. In Section 4 we prove that truncated polynomial algebras of the form Q[t]/tm and Z[t ...... othersee [21, Equation (1.7.2)]. An important case is X = S n . In this case we write THH[n],R (A; C) for ...
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Zou, Foling, Hedenlund, A., Klanderman, Sarah, Richter, B., and Lindenstrauss, A
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Part of special issue: Women in Topology III. Abstract: We develop a spectral sequence for the homotopy groups of Loday constructions with respect to twisted cartesian products in the case where the group involved is discrete....
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- ... , 13081315 doi:10.1242/jcs.156737 at 4 weeks and 9 weeks of age (supplementary material Fig. S1A; Fig. 1D ...... ) SMAD2/3. Whereas activated SMAD2/3 was unaffected in Bmpr2-cKO mice at 4 weeks of age (supplementary ...... of bone markers are unchanged in Bmpr2-cKO mice at birth (Gamer et al., 2011) and at 4 weeks of age ...... Acvr2a (B) and Acvr2b (C) in humerii of 4-week-old Bmpr2-cKO mice compared to Bmpr2-floxed littermates ...... Gender 4 weeks Male Female 9 weeks Male Female 15 weeks Male Female BV/TV vBMD BV/TV vBMD BV/TV vBMD BV ...
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Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.
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Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
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- ... known Broods Chicks EPY 5 2a 4b 4 17 7 14b 13 1 1 1 0 2 1 8 5 0 0 18 64 3 considered the putative father ...... ; Dunn and Cockburn 1996) to nonexistent in the Common Loon (Gavia immer; 0%; Piper et al. SHORT ...... assessed. Freeland et al. (1995) found socially monogamous Willow Ptarmigan to have a low (4%) rate of ...... breeding densities (1 4 breeding pairs per km2) and breeds from the middle of May through the middle of ...... chicks; 14%), and the other two were found in socially monogamous pairs (2 of 51 chicks; 4%) in 1996 and ...
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The White-tailed Ptarmigan (Lagopus leucurus) is one of the few socially monogamous species within the highly polygynous grouse subfamily (Tetraoninae). I found White-tailed Ptarmigan in Glacier National Park, Montana,...
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- ... prevent hyperphosphatemia [21]. Pi should be drawn every 4 weeks with corresponding dose adjustments based ...... Burosumab: 10 (83%) Placebo: 2 (50%) AEs related to burosumab: 6 (21%) IV: 4 (24%) SC: 2 (17%) AE leading to ...... , Pathophysiology and Pharmacology Jon Vincze 1,2 , Brian W. Skinner 3 , Katherine A. Tucker 4 , Kory A. Conaway 1,2 ...... , Jonathan W. Lowery 1,2, * and Julia M. Hum 1,2, * 1 2 3 4 * Citation: Vincze, J ...... osteocytes [4]. Mutation in the PHEX gene product leads to increased serum levels of FGF23. FGF23 is a potent ...
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Vincze, Jon, Hum, Julia, Conaway, Kory, Skinner, Brian, Tucker, Katherine, and Lowery, Jonathan
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The authors present a stereotypical case presentation of X-linked hypophosphatemia (XLH) and provide a review of the pathophysiology and related pharmacology of this condition, primarily focusing on the FDA-approved medication...
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- ... for God.4 3. The Early Developments of Confirmation The term seal (sphragis in Greek) was used in the ...... -century pope, who in fact never 3 4 5 6 7 8 9 (Austin 1990, p. 19). (Canales 2002, pp. 107, 111). (Austin ...... Decretum, Peter Lombards Sentences, and Thomas Aquinas Summa Theologiae.11 4. Confirmation Today Since 1910 ...... Bishops 1978, 118). (Harmon 2019, p. 4). She lists the dioceses, Saginaw, Michigan (1995); Great Falls ...... (2019). Religions 2020, 11, 417 4 of 13 5. The Current Approach to Adolescent Confirmation There are ...
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This article will briefly address the origins of confirmation and the current approaches to adolescent confirmation. Moreover, the article discusses the two predominant models of confirmation in the Catholic Church in the...
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- ... , 2021 Accepted: September 21, 2021 Published: September 24, 2021 Copyright 2021 by author(s) and ...... 470 Advances in Microbiology A. Ahmad, S. Akbar and global scales (e.g., climate) [21] [22] [23]. As ...... selected for this study are given in Table 1. Five seedlings (4 - 5 years old) were randomly selected for ...... : cluster 1: 41 clones; cluster 2:29 clones; cluster 3: 29 clones; cluster 4: 10 clones; cluster 5: two ...... Burkholderia group sequences (Figure 4). At the same time, a notable feature of this cluster is that RS ...
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The goal of this research was to determine the effects of the growth of invasive plant Amur Honeysuckle (Lonicera maackii) on the rhizosphere bacterial community composition, and diversity in an urban wetland forest ecosystem....
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- ... , 13461347. doi: 10. 1016/s0140-6736(21)00470-0 Chiara, M., Horner, D. S., Gissi, C., and Pesole, G. (2021 ...... Zhang 2 , Paul W. Bible 3 , Qiaoxing Liang 4 , Fangfang Zheng 5 , Ying Wang 1 , Yuantao Hao 1* and Yu ...... Sciences, Marian University, Indianapolis, IN, United States, 4 State Key Laboratory of Ophthalmology ...... Microbiology Received: 21 January 2022 Accepted: 18 February 2022 Published: 16 March 2022 Citation: Huang Q ...... j were quantified with an adjacency score using a power function (Horvath, 2011), 0 ys = 0 0 Aij ...
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Wang, Y., Zhang, Q., Liu, Y., Liang, Q., Zheng, F., Hao, Y., Bible, Paul, W., and Huang, Q.
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Early detection of SARS-CoV-2 variants enables timely tracking of clinically important strains in order to inform the public health response. Current subtype-based variant surveillance depending on prior subtype assignment...
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- ... mRNA. SiHa cells stably expressing GFP, NOL7 or HuR were treated for 0, 2, 4 or 6 with 5 mg/ml a ...... in complete media containing 5 mg/ml a-amanitin for 0, 2, 4 or 6 hours. After treatment, RNA was ...... this was not an artifact of overexpression (Figure 4, lanes 3 and 4). This was not due to nonspecic ...... binding (Figure 4, lane 5). Finally, to demonstrate that this interaction was mRNA-specic and not a random ...... times the input RNA was performed. NOL7 binding was lost in the polyA treatments (Figure 4, lanes 6 and ...
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Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
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- ... ops-4 ops-3 WRKY33 1 ol C 00 ol -0 min C 30 ol m i C 06 n ol 0 m -0 18 in op 0 m sin op 3 0 m sin 3 3 ...... detection (8, 23). Col-0 and both independent ops- 147 3 and ops-4 mutant alleles were grown in liquid media ...... signaling, 191 we measured the hypocotyls of Col-0, ops-3 and ops-4 seedlings grown in the light and the ...... D 40 30 5-23-19 Primary Root Growth OPS Col-0 Root Length (cm) B ops-4 10 b b 5 10 0 0 Col-0 ops-3 ...... ops-4 Col-0 ops-3 ops-4 4 3 0 4 3 ol -0 Figure 1. Characterization of two independent OPS T-DNA ...
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Stegemann, Katherine A., Collins, Carina, Melena, I., King, C., and Greenwood, K.
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Phloem is a critical tissue that transports photosynthates and extracellular signals in vascular plants. Although a functional phloem is necessary for plant health, it is also an ideal environment for pathogens to access host...
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- ... License 6 3 4 7 Headbob 1 Adjustment S. u. undulatus 0 Can2 (9.9%) 2 Chem 1 S. u. hyacinthinus S ...... . consobrinus 2 Travel 3 2 1 0 1 2 3 4 Can1 (90.1%) F I G U R E 3 Canonical discriminant plot for the ...... ) *** *** 20 15 10 5 0 S. consobrinus S. u. hyacinthinus S. u. undulatus F I G U R E 4 Behavioral differences ...... , Macon, Georgia, USA 4 Department of Biological Sciences, Southeastern Oklahoma State University, Durant ...... chemosensory behavior linked to 14390310, 0, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/eth ...
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Romero-Diaz, C., Wetherell, B., Ury, D., Reuter, M., Pruett, J., Martins, E., and Ossip-Drahos, Alison G.
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Animals evolve in complex selective regimes, where a suite of different factors can shape signal use. We might predict that more closely related species will exhibit more similar behavior than those more distantly related;...
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Preventing Pandemics and Containing Disease: A Proposed Symptoms-Based Syndromic Surveillance System
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- ... systems in place to track increase in existing as well as novel disease incidence [4-8] (Table 1); however ...... professionals) to reduce cholera cases from 400 to 0 in three weeks (Sofala, Africa, 2019) A conglomeration of ...... structures [3,15]. The third problem with current methods is fragmented communication and integration [4-8 ...... facilitated and correlated positively with use and health outcomes [21]. Open-access symptom tracker tools ...... -Overall reduction of crime -Decreased time of data transfer (21 days to instantaneous) -Decreased time of ...
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Mulye, Minal, Abraham, Benjamin M., Schmid, Aaron, Khan, Israt, and Akbar, Samina
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Background: Due to globalization, spread of a pandemic is inevitable as we have seen with COVID-19. Further, increased ease of travel increases the potential and frequency of pandemics. Hence, it is imperative to find solutions...
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- ... August 2022; Accepted 21 November 2022 regulators, that increase the expression of cytokines, chemokines ...... antagonized by the antiinflammatory cytokines interleukin-4 (IL-4) and IL-13, which promote an alternative ...... increase in t=0 versus 48 h; Fig. 1B), and this was mirrored at the protein level (Fig. 1C). This differs ...... expression at 24 h post-stimulus (Fig. 1F). However, IFN and LPS co-treatment stimulated a >4-fold increase ...... manner, similar to PTH-stimulated nuclear translocation of CITED1 in osteoblasts. 4 Journal of Cell ...
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Subramani, A., Hite, M., Garcia, S., Maxwell, J., Kondee, H., Millican, G., McClelland, Erin E., Seipelt-Thiemann, R., and Nelson, D.
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Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and...
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- ... . [27] 100% 0% 40% 100% 100% 10 (mean) 20 Grimaud et al. [118] 11% 71% 4% 96 ...... cardiovascular disease increases the risk of severe COVID-19 disease and death [4, 5], but does COVID-19 ...... heart, more highly expressed than in the lungs [21], and the SARS-CoV-2 virus binds and utilizes these ...... and induce microcirculatory disorders in the heart [26] (4) Damage Mediated by a Systemic Inammatory ...... % Coronary artery disease CHF Cardiomyopathy Previous MI 19% Dyslipidemia 100% 0% 57% 12% 6 ...
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Akella, K., Pareddy, A., Petrovic, M., Schmid, A., and Sakthi Velavan, Sumathilatha
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COVID-19 was primarily identified as a respiratory illness, but reports of patients presenting initially with cardiovascular complaints are rapidly emerging. Many patients also develop cardiovascular complications during and...
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- ... !"#!$$!%"&#' ()* +(*,,- .- ),, * . / - 0 ...... ) - 12( 3-4 ) 5 ...... ( !"# $ % &' %(')"#*+,! -./00 /1/2 56 ...... ( ! " # $ % # & $' ( ) (# # $ ) (* !#+ ## ,-!.* /#$$# $#/ # (((# / $ ! #$ % #0/ !# 1% #* 2'# ARTS EDUCATION POLICY REVIEW https://doi.org/10.1080 ...... music and music education (p. 4). CONTACT Melissa A. Arnold ! 2019 Taylor & Francis Group, LLC ...
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Goodman, Shawn L. (Marian University), Ellerbe, Amanda E., and Arnold, Melissa A.
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In his book, Music Education in an Age of Virtuality and Post-Truth, Woodford presents a welcomed discussion of the aims of music education in a time of political unrest. This timely text is needed due to the stresses of the...
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- ... change was made to increase the clarity and conciseness of the prompt. Prompt section 4 accounted for the ...... of prompt section 4 was separated into two bullets and prepositions were removed to increase clarity ...... indicated that the students 15:ar63, 4 thought they did not need to follow this direction. Therefore, the ...... developed first by addressing the central concepts and common FIGURE 4. Rubric used to analyze scientific ...... scientific findings; and 4) a scientific community is necessary for scientific progress (communication ...
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The scientific process is nonlinear, unpredictable, and ongoing. Assessing the nature of science is difficult with methods that rely on Likert-scale or multiple-choice questions. This study evaluated conceptions about the...
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- ... cells 20 5 shCXCR4 0 28 Time (days) 50m 500m K shControl 21 H Normal LN 500m shControl shCXCR4 14 ...... 0 103 dorsal tongue Lymph nodes invaded (%) Cumulative population doubling 5 0 102 200 CXCR4 E 4 D ...... Health, Bethesda, Maryland Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 ...... Abbreviations: CXCL12, C-X-C motif chemokine 12; CXCR4, C-X-C motif chemokine receptor type 4; EGF, epidermal ...... (3). The C-XC motif chemokine receptor type 4 (CXCR4) 7-transmembrane G proteincoupled receptor binds ...
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Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
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Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
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- ... is derived from scientific societies based in the United States targeting medical students in the 4 ...... General Internal Medicine (CDIMSHIM) [14], have content that is usually covered in years 3 and 4 of ...... Education of Anesthesia 2009 Behavioral Sciences ADMSEP [4] Association of Directors of Medical Student ...... Physiology 2012 Radiology AUR [21] Association of University Radiologists 2014 to various schools, but the ...... / Society Abbreviation 13,121 (100) 2 Year 13,121 (100) 3 Objective 13,121 (100) 4 Subheading 1 13,121 (100 ...
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BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common
gold standard
resource used building curricula are medical objectives suggested by national...- Type:
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- ... is derived from scientific societies based in the United States targeting medical students in the 4 ...... General Internal Medicine (CDIMSHIM) [14], have content that is usually covered in years 3 and 4 of ...... Education of Anesthesia 2009 Behavioral Sciences ADMSEP [4] Association of Directors of Medical Student ...... Physiology 2012 Radiology AUR [21] Association of University Radiologists 2014 to various schools, but the ...... / Society Abbreviation 13,121 (100) 2 Year 13,121 (100) 3 Objective 13,121 (100) 4 Subheading 1 13,121 (100 ...
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BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common
gold standard
resource used building curricula are medical objectives suggested by national...- Type:
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- ... /CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain Carmela L. Marciano 1,2, , Taylor ...... . Lowery 1,2,3,5,8,9, * 1 2 3 4 5 6 7 8 9 * Citation: Marciano, C.L.; Hiland, T.A.; Jackson, K.L.; Street ...... Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain. Int. J. Mol ...... : 18 August 2023 Revised: 12 September 2023 Accepted: 17 September 2023 Published: 21 September 2023 ...... ) ligand 5 (CCL5) and increased soft tissue levels of Interleukin (IL)-4, which are pro-inflammatory and ...
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Marciano, Carmela L., Hiland, Taylor A., Chu, TM, Kang, Kyung S., Lowery, Jonathan W., Jackson, Krista L., Street, Sierra, Maris, Carson, Ehrsam, Andrew, Hum, Julia M. , and Loghmani, M
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Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive...
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- ... , yet substantial, on certain components of the GDP. 8% 6% 4% 2% 0% -2% -4% -6% 2007 2008 EU 2009 US ...... . J. Financial Stud. 2020, 8, 26 4 of 22 and the fourth section describes the methodology leading to ...... FOR PEER REVIEW 4 of 22 2. Chilean Institutional Context 2. Chilean Institutional Context Chiles ...... 30% 25% 20% 15% 10% 5% 0% -5% -10% -15% -20% 2007 2008 2009 5 of 22 5 of 22 2010 2011 2012 2013 GDP ...... crisis was large relative the US crisis. Figure 4 displays household financial net worth, and shows that ...
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The study examines evidence for the transmission of the US and EU financial crises via investor holdings into the Chilean stock market following two global financial crises, in 2008 and 2011. The study modified the models of...
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Panichpisal, K, Schwartz, B G., Warner, D S., Babygirija, R, Biddick, L; , Rovin, R A., Kassam, A B, Sajjad, R., and Chohan, Adil OMS-2
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BACKGROUND: Patients with an acute ischemic stroke (AIS) following cardiac catheterization (CC) generally do not receive intravenous thrombolysis [intravenous tissue plasminogen activator (IV-tPA)] as it is contraindicated due...
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- ... . Contents 1. Introduction 2. The universal cotrace 3. Bicategories of bicomodules 4. CoHochschild homology ...... , L(f ). If L(f ) 6= 0, then f is has at least one fixed point [Lef26, Lef37]. The definition of the ...... defines a bicategorical shadow, is proved in Section 4. We then explore the notion of duality in ...... bicomodules in Section 5, which has been 4 under-documented in the literature thus far. In Section 6, we ...... contexts: (c) = n X c(1) i c(2) i =: c(1) c(2) , and (m) = n X m(0) i m(1) i =: m(0) m(1) . i=1 i=1 be ...
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We provide traces for coHochschild homology, dualizing the Hattori-Stallings trace. Considering the trace of the identity, we define traces between coHochschild homology and certain K-theories of coalgebras. We employ...
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- ... 3 ** 4 TLE3 0 Moc 2 Myf5 5 MCK0.8-luc 3 2 ** 1 Myogenin TLE3 MRF4 F 1.6 MCK0.8-luc 1.4 4 0 Moc 1 ...... ** 1.2 1 0.8 0.6 0.4 0.2 0 Moc 6 ** 2 Moc 8 3 0 Relative expression 10 E Moc 12 4 Myogenin Relative ...... TLE3 Moc 0 ** 3 TLE3 5 C 6 TLE3 10 MG185-luc Moc 15 4 Moc 20 Moc Relative expression 25 B Moc MG185-luc ...... expression 16 14 12 10 8 6 ** 4 2 0 Moc Moc 1-782 1-461 Runx2 Supplemental Figure 4. The WD domain deletion ...... * Relative expression 2 ** 1.8 1.6 ** 1.4 1.2 1 0.8 0.6 0.4 0.2 0 E12 (ng): 10 2 100 3 200 4 50 ...
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Addison, William N, Yoda, Tetsuya, Rosen, Vicki, Nakatomi, Mitsushiro, Nakatomi, Chihiro, Urata, Mariko, Hitomi, Suzuro, Osawa, Kenji;, Jimi, Eijiro, Sato, Tsuyoshi, Ono, Yusuke, Kokabu, Shoichiro, Matsubara, Takuma, Hudnall, Aaron M, and Lowery, Jonathan W.
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Satellite cells are skeletal muscle stem cells that provide myonuclei for postnatal muscle growth, maintenance, and repair/regeneration in adults. Normally, satellite cells are mitotically quiescent, but they are activated in...
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- ... , La Jolla, CA, USA 4.Oral Immunity and Inflammation Unit, National Institute of Dental and ...... ). Clinical screening was performed (Day 0) followed by baseline biopsies to create paired identical wounds in ...... June 28. Iglesias-Bartolome et al. Page 4 Author Manuscript (1473); Skin Day 6 / Day 1 (1836) (Fig. 2B ...... skin continuously through day 6 (Fig. 4B). Additionally, markers of fibrosis, including TGF- (21) are ...... models (4), suggesting a conserved mechanism in oral keratinocytes that allows for faster wound ...
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Onaitis, Mark W., Asselin-Labat, Marie-Liesse, Gutkind, J. S., Uchiyama, Akihiko, Callejas-Valera, Juan Luis, Abusleme, Loreto, Molinolo, Alfredo A., Edwards, Dean, Moutsopoulos, Niki M., Iglesias-Bartolome, Ramiro, Morasso, Maria I., Doci, ColleenL., and Brooks, Stephen R.
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Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We...
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- ... set apart from other popular, but humorous WendemMNTMJLFGood Bye, Lenin! and Sonnenallee.4 Despite ...... do the right thing, no matter how far they have gone down the wrong path.21 Thus, on this level, the ...... ABVUIFOUJDBMUIPVHITPNFJOBDDVSBUFFMFNFOUTJOUIF plot were quite obvious to every expert. 4. Lindenberger ...... HVBSEJBODPVLGFBUVSFT /featurepages/0,,2072629,00.html#article_continue. 18. Funder, Tyranny of Terror ...... of Ostalgie: 1PTU4PDJBMJTU/PTUBMHJBJO3FDFOU(FSNBO'JMN wScreen 48, no. 4 (Winter 2007): 490. 27 ...
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With his 2006 film Das Leben der Anderen (The Lives of Others), writer and director Florian Henckel von Donnersmarck asserted that he had
created a GDR that is truer than the real thing, that is realer than the actual GDR.
In...- Type: