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- ... 11/13/08; revised 2/7/09; accepted 3/4/09; published OnlineFirst 3/31/09. Grant support: Abbott ...... negative staining intensities were scored as 3, 2, 1, and 0, respectively. For each of the intensity scores ...... tongue lesions are shown in Fig. 3. At week 4 (n = 10), 50% of the tongues were histologically Discussion ...... ; 1995. 3. Day GL, Blot WJ. Second primary tumors in patients with oral cancer. Cancer 1992;70:149. 4 ...... Research ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral ...
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Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen
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Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...
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- ... % 2.9% 9.6% 0 (0) 46 (82.1) 4 (7.1) 1 (1.8) 5 (8.9) 3 (3.6) 66 (78.6) 1 (1.2) 4 (4.8) 9 (10.7) 1 (1.7 ...... ) 43 (74.1) 4 (6.9) 3 (5.2) 7 (12.1) 6 (8.1) 60 (81.1) 3 (4.1) 0 (0) 5 (6.8) 0.3% 71% 27.8% 0% 1% 0 (0 ...... ) 17.8% 9.7% 1.7% 2.6% 5 (8.9) 4 (7.1) 0 (0) 3 (5.4) 23 (27.4) 11 (13.1) 3 (3.6) 2 (2.4) 10 (17.2) 6 ...... (63.1) 43 (74.1) 52 (70.3) Other 3.5% 1 (1.8) 4 (4.8) 2 (3.5) 3 (4.1) No benefit 0.3% 0 (0) 1 (1.2) 0 (0 ...... 1,2 , Sarah Zahl 5,6 , Michael Baumann 7 and Jonathan W. Lowery 1,2,8, * 1 2 3 4 5 6 7 8 * Citation ...
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Zahl, Sarah, Hum, Julia M., Jackson, Krista L., Griffin, Nicole, Lowery, Jonathan W., Nick, Benjamin, Herber, Jake, Hamby, T., Baumann, Michael, and Ogunbekun, Oladipupo
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Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and life-long learning skills, greater appreciation for evidence-based...
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- ... in 4% of individuals, and this group measured under 5 mm and 3 mm in children and infants ...... SAN posterior to the split vein; type 3 (0.7%) had the SAN between the split veins; type 4, 7 which ...... arteryinternal jugular vein fistula. Pediatr Surg Int. 2011;27(12):1375-6. doi: 10.1007/s00383-0112918-0. 3 ...... During Ultrasound-Guided Cannulation. Turk J Anaesthesiol Reanim. 2015;43(3):212-4. Epub 20150216. doi ...... literature search was conducted using the databases, Pubmed and Google Scholar. The 3 Medical Subject ...
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Kosnik, Natalie, Kowalski, Taylor, Lorenz, Lorraine, Valacer, Mercedes, and Sakthi-Velavan, Sumathilatha
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The internal jugular veins (IJV) are the primary venous outflow channels of the head and neck. The IJV is of clinical interest since it is often used for central venous access. This literature aims at presenting an overview of...
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- ... 3: C02 (a), 4: C02 (b), 6: C20 , 7: C60 (a), 8: C18 0 , and 9: C1 ]. 0.32%, respectively (Table I ...... : 11 October 2022 Published Online: 4 November 2022 Hansika I. Sirikumara,1,a) Wilson Rativa-Parada,2 ...... Robinson Karunanithy,3 Poopalasingam Sivakumar,3 Sabrina Nilufar,2,b) and Thushari Jayasekera3 AFFILIATIONS ...... Carbondale, Carbondale, Illinois 62901, USA 3 School of Physics and Applied Physics, Southern Illinois ...... composites.4 Graphene, a carbon allotrope, is used as the reinforcement in this study. In the process of ...
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Jayasekera, T., Nilufar, S., Karunanithy, R., Sivakumar, P., Rativa-Parada, W., and Sirikumara, Hansika
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Embedding carbon in metals has long been known to enhance the mechanical properties of metal carbon composites. We report the possibility of growing Al–C composites by the hot isostatic pressing method, with carbon embedded...
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- ... Fishback Creeks canal systems; (3.) Shows the relationship between the canal systems in the NMP EcoLab; and ...... (4.) The 2009 map of canal system NMP EcoLab 2 showing the relationship between beaver-cut stumps ...... ) between the two areas. 2. there were no cut stumps in the 120m gap between the two areas; and 3. there ...... % 100.00% 100.00% 61.04% 80.33% 0 0 6 6 6 6 6 6 6 6 83 261 206 451 130 178 N/A 421 N/A 932 54 30 58 96 154 ...... . 1923. Observations on a Montana beaver canal. Journal of Mammalogy 4:92103. Brenner, F.J. 1962. Foods ...
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Kot, Amanda, Nicholson, Jody, Black, Matt, Abbott, Matthew J., Wilson, Jon, Thomas, Adam, Schaffer, Benton, Fultz, Brandon, Benson, David P., and Burrows, Mallory
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Castor canadensis Kuhl (North American beavers) are central place foragers who
collect woody plants and building materials from their surroundings and return to a main body of water containing a lodge or food cache. It has...- Type:
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- ... of the plate (37 C, 5% CO2, 0% O2) for 4 hours. After 4 hours, 100 L of detergent (0.01N HCl with 10 ...... average % viable cells (SD) with N=3. Average % significantly different from the no BME control cells (**P ...... ). Cumulative data of average % cell viability (SD) with N=3. Average % significantly different (*P < 0.01), one ...... viability (SD) with N=3., DMEM; Dulbeccos Modified Eagles Medium. 9/5/2023 - Open Access Description ...... lower the blood glucose levels by increasing GLUT-4 transporter mediated downstream signaling pathways ...
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Kakuturu, Abhinav , Choi, Heeyun , Noe, Leah G., Scherer, Brianna N., Sharma, B., Khambu, B., and Bhetwal, Bhupal P.
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Breast cancer is one of the most commonly diagnosed cancers among women, however the complete cure for metastatic breast cancer is lacking due to poor prognosis. There has been an increasing trend of dietary modifications...
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BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.
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- ... (BMP3 LacZ knock-in). To examine skeletal expression of BMP3, we analyzed heterozygous mice at 4 wk of ...... Endocrinol, January 2012, 26(1):8794 FIG. 1. OBL and OCY express BMP3. Tibia from BMP3 4-wk-old LacZ knock-in ...... expressed effects of BMP3 on cells in which enreduced levels of osteocalcin (OC) on d 3, as determined by ...... quantitative real time PCR dogenous Acvr2b had been knocked analysis. Data are shown as the mean SD (n 3 ...... - pared with control/scrambled RNA oligonucleotides (Fig. FIG. 3. BMP3 suppresses BMP-Smad signaling. A ...
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Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
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Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
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- ... 13621627 13621698 0 0 3 UTR 30 UTR 30 UTR Predicted biologic consequence Loss of hsa-miR-1225-3p, -145 ...... -GTAGAGTATTTT TAGTGGGGTTTATT-30 and 50 -AAACTACACCA TAACCCA-30 ) (Figure 4). The PCR program used was 941C for ...... detection. All sections were counterstained with hematoxylin and scored on a 0 to 2 scale, with 0 being the ...... (staining intensity 1 and 2) or absent (staining intensity 0) against normal CIN I versus CIN II CIN III ...... with 293T controls. Po2 104; Fig. 1B). Four of these cell lines, Ca Ski, ME-180, SiHa, and SW756 ...
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Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
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NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
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- ... the two, except between sudangrass chromosome 4 and the reference chromosome 5 (Fig. 3). In this case ...... evolution, GWAS, Dhurrin biosynthesis Posted Date: July 6th, 2022 DOI: https://doi.org/10.21203/rs.3.rs ...... 3 UTR of Sobic.001G012300 which encodes CYP79A1, the enzyme that catalyzes the first step of dhurrin ...... and pathogens (Gleadow et al. 2014). Page 3/21 In sorghum, dhurrin is synthesized from L-tyrosine in ...... two SNP and one indel marker. These markers were all located in the 3 UTR of Sobic.001G012300 coding ...
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Bible, Paul, W., Wang, L., Jin, P., Zheng, J., Wang, Y., Zhan, Q., Li, J., Liu, Y., and Tu, W.
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Sudangrass [ Sorghum sudanense (Piper) Stapf] is a hybrid between grain sorghum and its wild relative S. bicolor ssp. verticilliflorum and is grown as a forage crop due to its high biomass production and low dhurrin content...
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Providing safe and effective care is identified by the Quality and Safety Education for Nurses (QSEN) guidelines as an essential competency (QSEN, www.qsen.org). First semester nursing students are challenged to evaluate their...
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- ... -eutherian animal (0/136). We also identified multiple conserved transcription factor binding sites in the ...... ligands BMP2/4 and BMP5/6/7 (Dpp and Gbb in Drosophila, respectively) share dramatic identity, BMP3 is ...... TGF-b/Activin and BMP ligands [9,10] and shares only 40% amino acid identity with the ancestral BMP2/4 ...... mammals was its ability to induce ectopic bone formation [3], BMP signaling has since been implicated in ...... was assayed using the Dual-Glo Luciferase Assay System (Promega). Cells were seeded at 3 k/cells per ...
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The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...
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- ... Change 8 3 6 +M ur y In j t ro on +M ur y In j C y In ju r t ro y 0 In ju r 0 FR 2 l 1 FR 4 l b 2 on FR ...... -inflammatory cytokines. J Bodyw Mov Ther, 2008. 12(3): p. 201-3. 4. Meltzer, K.R., et al., In vitro modeling of ...... ry C In +M ju r tro on 0 +M 0 y 0 5 l 5 y 20 10 l 15 15 tro 60 20 pg/mL 20 pg/mL 80 40 Run #3 IL-6 ...... Combined IL-6 ELISA Fold Change Combined IL-6 CBA Fold Change 4 a a 3 4 b 2 2 1 Combined IL-8 CBA Fold ...... on C l 0 l 0 tro Fold Change 6 Fig. 4 Graphs displaying the average fold change of each run between ...
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This experiment analyzes three different techniques used in literature to detect cytokine release from cells in vitro: the Human Cytokine Array (HCA) by R&D Systems, the BD Cytometric Bead Array (CBA) assay, and protein...
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- ... available from the authors. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20 ...... , Nathan D. Hubbard 1 , Adam M. Green 2 , Gregory K. Webster 3 and Patrick A. McVey 1,2, * 1 2 3 ...... enabling tablet formulation [4]. Crystallinity can be an issue for BCS Class II/IV drugs if the active drug ...... acetaminophen tablets [4]. ELDI is similar to MALDI; however, ionization via an applied matrix is replaced by ...... the sample surface, it creates a plume of ablated material. This plume Molecules 2021, 26, 610 3 of ...
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Khan, Salah, McVey, Patrick, Taulbee-Cotton, Brynne, Webster, G, Van Meter, Mariann, Hubbard, Nathan, Dimmitt, Nathan, and Green, Adam
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Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as...
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- ... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...... resections. Here, we explored the feasibility of developing a sensitive assay system for desmoglein 3 (DSG3 ...... decades.3 HNSCC has a high propensity to metastasize to loco Corresponding author. Address: Oral and ...... mucosa and HNSCC lesions revealed a very high abundance of Desmoglein 3 (DSG3) in both non-neoplastic ...... protein standards or 4 ll tissue extract were diluted 1:6000 in RIPA buffer and added to the bioconjugates ...
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Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
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OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
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- ... We would like to thank Sue Samson for her administrative support. REFERENCES 1 2 3 4 5 6 7 8 9 10 11 ...... fractures[3]. Fractures in the elderly population are associated with a unique set of geriatric-specific ...... with plates, screws, nails and wires in surgically treated fractures [4-10] . For example, studies have ...... process was documented in many patients, the phase 3 trial failed to reach its clinical endpoint due to ...... : 10.1016/S0736-0266(00)90034-2] Lopas LA, Belkin NS, Mutyaba PL, Gray CF, Hankenson KD, Ahn J. Fractures in ...
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Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.
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Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
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- ... Machine Vision Engineering Technology Research Center, Guangzhou, China, 3 College of Arts and Sciences ...... , Marian University, Indianapolis, IN, United States, 4 Institute of Public Health, Guangzhou Medical ...... intractable due to a daunting computational hurdle of using gold-standard phylogenetic approaches (4). Routine ...... hypothesis testing problems with H0 : ij = 0 (Figure 1A). Our analysis considered only co-mutations with ...... k X mi N mi ij s e / e (2) mj k s mj s s=0 for max mi + mj N, 0 k min(mi , mj ) and the same ...
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Huang, Q., Qiu, H., Bible, Paul W., Huang, Y., Zheng, F., Gu, J., Sun, J., Hao, Y., and Liu, Y.
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Background
Precise public health and clinical interventions for the COVID-19 pandemic has spurred a global rush on SARS-CoV-2 variant tracking, but current approaches to variant tracking are challenged by the flood of viral...
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- ... . 5 4.5 4 Satisfaction Control 3.5 Satisfaction Intervention 3 Task Conflict Control 2.5 Task Conflict ...... . Journal of Management, 21(4), 691-710. doi:10.1016/0149-2063(95)90006-3 Rai, H. (2013). The measurement of ...... Intervention 2 1.5 Relationship Conflict Control 1 Relationship Conflict Intervention 0.5 0 Phase I Phase II ...... conflict management. International Journal of Conflict Management, 12(1), 4-22. De Dreu, C., & Weingart, L ...... -analysis. Journal Of Applied Psychology, 88(4), 741-749. doi:10.1037/00219010.88.4.741 de Wit, F., Greer, L ...
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Conflict can have detrimental effects on team interaction, performance, and member satisfaction, so research on tools and techniques aimed at reducing or resolving conflict is crucial. This study trained the leaders of teams...
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- ... proliferation assay. Cell proliferation of HUVECs was evaluated through the MTT (3-[4, 5-dimethylthiazol-2-yl]-2 ...... gradually dissolved in M199 (6 g in 500 ml) under stirring at 4 C overnight. The supernatant from a 3 h ...... at room temperature and incubated with Alexa 594 Phalloidin 1:100 in PBS with 3% BSA overnight at 4 C ...... clarify the role of endothelial RhoA during tube formation, a 3-D sprouting assay was introduced, where ...... toxin (20 ng/ml) treatment. Full-length blots are presented in Supplementary Fig. 4. (C) Representative ...
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Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
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Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
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- ... in Gq and G11 leads oncogenic transformation [3, 4] and is particularly prevalent in the development ...... intensity (0, absent; 1, weak staining; 2, moderate staining; and 3, strong staining) multiplied by the ...... starved for 6 hours and then treated for 3 hours with either 0, 1, or 10 ng/ml TGF-1. Cells were fixed ...... LifeActGFP were treated with 0, 1, or 10 ng/ml TGF-1 for 3 hours and assessed for cytoskeletal changes ...... Tech University Health Sciences Center, Amarillo, Texas, United States of America, 3 Department of ...
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Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
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G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
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- ... collagen fibers (2), scattered fibroblast (3), and venules (4) was found to arise from the vagus nerve on ...... 13 302 2. 3. 4. 5. 6. 7. 8. 9. 10. Surgical and Radiologic Anatomy (2023) 45:297302 tumors of the ...... carotid triangle of the neck, is a nerve loop arising from cervical nerve roots C1, C2, and C3 [3]. This ...... deglutition [3, 5]. Typically, the superior root of the ansa cervicalis is derived from C1 nerve fibers ...... been estimated to occur in less than 1% of reported cases [3]. Although usually asymptomatic, awareness ...
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Dykstra, Chandler, Dwenger, Emma, Parent, Elizabeth, and Sakthi-Velavan, Sumathilatha
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Purpose: This case report aims to explore a rare combination of findings in a cadaver donor: variant ansa cervicalis, vagus (CN X) and hypoglossal (CN XII) nerve fusion, and extracranial hypoglossal neurofibroma.
Background:...
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