Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common "gold standard" resource used building curricula are medical objectives suggested by national...
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common "gold standard" resource used building curricula are medical objectives suggested by national...
Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) pa-
tients as a phosphate (Pi) binder for dialysis-dependent CKD, and for iron de-
ficiency anemia (IDA) in non-dialysis CKD. Elevated Pi and IDA...
SEMA3F is an antilymphangiogenic signaling molecule expressed in the proliferating basal layer of normal epithelium. In orthotopic models of head and neck squamous cell carcinoma, loss of SEMA3F or its receptors results in...
Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer....
The Coronavirus Disease 2019 (COVID-19) pandemic led to the swift development of multiple vaccinations. Vaccine side effects were well-documented in the healthy adult cohort and included fever and lymphadenopathy, however, side...
The Coronavirus Disease 2019 (COVID-19) pandemic led to the swift development of multiple vaccinations. Vaccine side effects were well-documented in the healthy adult cohort and included fever and lymphadenopathy, however, side...
Reductions in skeletal muscle mass and function are often reported in patients with cancer-associated weight loss and are associated with reduced quality of life, impaired treatment tolerance, and increased mortality. Although...
Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive...
Women in medicine have made progress since Elizabeth Blackwell: the first women to receive her medical degree in the United States in 1849. Yet although women currently represent just over one-half of medical school applicants...
The study examines evidence for the transmission of the US and EU financial crises via investor holdings into the Chilean stock market following two global financial crises, in 2008 and 2011. The study modified the models of...
This essay explores how the legacy of asceticism from patristic spirituality may be retrieved alongside constructive ecclesiology and studies in embodied cognition to enliven modern ecumenical method. Asceticism concerns the...
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-? family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical...
Spin–orbit coupling enables the realization of topologically nontrivial ground states. As spin–orbit coupling increases with increasing atomic number, compounds featuring heavy elements, such as lead, offer a pathway toward...
Advances in radiology and imaging technologies and the emergent scope of practice have led to the capacity to provide services to a growing population of high-acuity patients with comorbid conditions. These procedures are often...
<strong>Targeting early steps in amyloid-beta production:</strong> Alzheimer's disease (AD) has a long history as the “amyloid deposit” disorder. Many disorders are now known to be caused by protein ?-sheet misfolding and...
I believe this article emphasizes how emotionally valuable receiving patients' trust is to the practicing physician. It also gives new insight into understanding the emotional loss a physician may experience when leaving...