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1/1/2015

Editor

Nature Publishing Group

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

Correspondências de palavras-chave:

... Factor (VEGF) and Sphingosine-1 Phosphate (S1P). In vivo, through constitutive and inducible endothelial ...

... family are Ras homolog gene family, member A (RhoA), Ras-related C3 botulinum toxin substrate 1 (Rac1 ...

... of a variety of cell surface 1 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech ...

... : constantinos.mikelis@ttuhsc.edu) Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 1 ...

... factor (VEGF)10 and sphingosine-1-phosphate (S1P)11,12. Global deficiency of each Rho GTPase leads to ...

mais >>

O Criador:

Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace

Descrição:

Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...

Tipo:

Article
The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

Correspondências de palavras-chave:

... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...

... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...

... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...

... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...

... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...

mais >>

O Criador:

Zhou, G., Doci, Colleen L., and Lingen, M.W.

Descrição:

Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...

Tipo:

Article

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

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