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10/3/1966

Herausgeber

Impact Journals, LLC

The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging

Keyword-Übereinstimmungen:

... with elevated PUFAs may accumulate more oxidative damage. On the other hand, 10-day asm-3 mutants have ...

... independent replicates of 1-, 5-, and 10-day old adult worms of different genotypes. We profiled N2, asm-3 ...

... sphingolipids (SLs). (B) Survival of 1-, 5-, and 10-day old N2 (blue), asm-3 (red), and hyl-2 (green) worms ...

... asm-3 1 day; n=35 for asm-3 10 day; n=28 for hyl-2 1 day; n=44 for hyl-2 10 day). (C) Representative ...

... hyl-2, asm-3, daf-16, and eat-2 backgrounds to that of wildtype 10-day animals (Figure 4C4F ...

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Schöpfer:

Staab, Trisha, McIntyre, Grace, Bromley, S., Raftery, D., Chan, Jason, Wang, L., Radeny, J., Bettcher, L., Guillen, Melissa, Peck, M. , and Kalil, A.

Beschreibung:

Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age...

Ressourcentyp:

Research Paper