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2015

Publisher

Federation of American Societies for Experimental Biology (FASEB)

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Keyword matches:

... and spontaneous metastasis via a CXCR4/Gai/mTORC1 axis. FASEB J. 29, 10561068 (2015). www.fasebj.org ...

... 2015 Time-lapse and 3-dimensional acquisitions were performed using an Olympus IX81 microscope equipped ...

... Vol. 29 March 2015 EGF receptor and LPA receptormediated migration (Fig. 2D). Moreover, treatment with ...

... expected, Rictor shRNA 1062 Vol. 29 March 2015 abrogated AktS473 phosphorylation (Fig. 5A) and Raptor shRNA ...

... endogenously as an experimental model 1064 Vol. 29 March 2015 system to investigate the downstream signaling ...

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Creator:

Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia

Description:

Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...

Type:

Article