Osteoporosis is a silent, dangerous pathology frequently undiagnosed until patients experience a major fracture. About 1 in 2 women and 1 in 4 men ages 50 and above will experience bone fractures due to osteoporosis. Fractures...
Spinal muscular atrophy (SMA) consists of a group of neuromuscular disorders characterized by degeneration of alpha motor neurons, leading to a lower motor neuron-type syndrome. Children afflicted with SMA 1 and 2 are prone to...
Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
Context: Skeletal unloading due to disuse, disease, or aging increases bone loss and the risk of skeletal fracture. Conversely, mechanical loading is anabolic to the skeleton, promoting skeletal integrity through increased bone...
Chemotherapeutic agents, such as vincristine, are well known
antineoplastic and cytotoxic drugs, affecting patients broadly during
treatment of cancer. Well known side effects, such as constipation
and neuropathic pain,...
Blunt cerebrovascular injury (BCVI) is rare but has been identified in trauma victims with increasing frequency in recent years due to improvements in imaging techniques and screening protocols. The incidence of BCVI is...
Due to the availability of information on the internet, patients are well informed of the several types of hernia repair available to them. They are also increasingly made aware of the litigious environment surrounding...
Purpose: To establish an ex vivo model of paclitaxel induced peripheral neuropathy that can be translated clinically using induced human neurons. Experimental Design: Human induced pluripotent stem cells (iPSCs) will be...
Papillary glioneuronal tumors (PGNTs) are rare, benign neoplasms that are typically solid or solid/cystic, well-circumscribed, parenchymal, solitary, and calcify. While intraventricular location, tumoral hemorrhage, and/or...
Rubella was first described in the 1750s but took until 1941 when Congenital Rubella Syndrome was characterized to become medically significant. Similarly, zika virus was discovered in 1947 but only made headlines in 2016 when...