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ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis.

Correspondências de palavras-chave:: ... Research ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral ...

... Carcinogenesis Rifat Hasina,1 Leslie E. Martin,1 Kristen Kasza,2 Colleen L. Jones,1 Asif Jalil1 and Mark W ...

... with preventive strategies. Using the 4-nitroquinoline 1-oxide (4-NQO) mouse model, we sought to define ...

... year (1). Despite numerous advances in therapy, the long-term survival for these patients has remained ...

... progression in an animal model whose genome is most similar to humans (1922). Although the 4-nitroquinoline 1 ...

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O Criador:: Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen
Descrição:: Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...
Tipo:: Article

Diet of the Myotis Sodalis (Indiana Bat) at an Urban/Rural Interface

Correspondências de palavras-chave:: ... 2004. We used two 1-m2 quadrats covered with window screening to collect guano under a known roost tree ...

... this study were to 1) determine the diet of Indiana bats at the Indianapolis Airport, and 2) compare ...

... from two 1-m2 quadrats covered with window mesh beneath a single roost tree during the 13-week 1 Marian ...

... presence of 9 orders and 26 families of arthropods in the diet (Table 1). Included were 5 pest species ...

... (Fig. 1) reported in earlier studies conducted in more rural areas of Indiana (Belwood 1979, 2006 N.M ...

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O Criador:: Tuttle, Nicole M., Sparks, Dale W., and Benson, David P.
Descrição:: We conducted a study of the diet of the federally endangered Indiana bat (Myotis sodalis) at an urban/rural interface near Indianapolis International Airport in summer 2004. We used two 1-m2quadrats covered with window...
Tipo:: Article

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.

Correspondências de palavras-chave:: ... 26 April 2012 Received in revised form 19 July 2012 Accepted 1 August 2012 Available online 23 ...

... of the head and neck (HNSCC) represent one of the ten most common cancers globally,1 and result in ...

... , Building 30, Room 211, Bethesda, MD 20892-4330, United States. Tel.: +1 301 496 6259; fax: +1 301 402 0823 ...

... protein standards or 4 ll tissue extract were diluted 1:6000 in RIPA buffer and added to the bioconjugates ...

... 66 76-100 51-75 26-50 1-25 80 60 40 20 0 PD 30 10 1 3 0.3 Recombinant DSG3 (ng) 100 Tubulin PD DSG3 ...

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O Criador:: Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.
Descrição:: OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...
Tipo:: Article

Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.

Correspondências de palavras-chave:: ... , comprehensive treatment plans must include improved chemopreventive strategies. Using the 4-nitroquinoline 1 ...

... the sixth most common malignancy in the world today (1). There will be over 35,000 new cases in the ...

... . First, OSCC is often diagnosed at an advanced stage. The 5-year Authors' Affiliations: Departments of 1 ...

... VEGF ligands are mediated through their binding to members of the VEGF receptor family (VEGFR-1, VEGFR ...

... were incubated using primary antibody to pVEGFR-2 1:300 (Abcam) or pEGFR 1:250 (Cell Signaling) for 1 ...

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O Criador:: Mankame, Tanmayi P., Zhou, Guolin, Wroblewski, Kristen, Lingen, Mark W., Doci, Colleen L., and Hasina, Rifat
Descrição:: Despite recent therapeutic advances, several factors, including field cancerization, have limited improvements in long-term survival for oral squamous cell carcinoma (OSCC). Therefore, comprehensive treatment plans must include...
Tipo:: Article

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

Correspondências de palavras-chave:: ... Factor (VEGF) and Sphingosine-1 Phosphate (S1P). In vivo, through constitutive and inducible endothelial ...

... family are Ras homolog gene family, member A (RhoA), Ras-related C3 botulinum toxin substrate 1 (Rac1 ...

... of a variety of cell surface 1 Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech ...

... : constantinos.mikelis@ttuhsc.edu) Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 1 ...

... factor (VEGF)10 and sphingosine-1-phosphate (S1P)11,12. Global deficiency of each Rho GTPase leads to ...

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O Criador:: Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
Descrição:: Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
Tipo:: Article

The functional loss of ceramide metabolism enzymes ceramide synthase and acid sphingomyelinase on lipid metabolism and healthspan

Correspondências de palavras-chave:
O Criador:: Wang, Lou, Staab, Trisha, Radeny, J, McIntyre, Grace, and Chan, Jason
Descrição:: The increase in our aging population in combination with the growing incidence of late-life conditions presents a need for research on healthy aging. Here, we present work examining the roles of sphingolipid metabolism on...
Tipo:: Conference Proceeding

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma

Correspondências de palavras-chave:: ... Research. 2939 Published OnlineFirst May 7, 2015; DOI: 10.1158/0008-5472.CAN-14-3121 Doci et al. Figure 1 ...

... , 2015. References 1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144 ...

... Published OnlineFirst May 7, 2015; DOI: 10.1158/0008-5472.CAN-14-3121 Cancer Research Tumor and ...

... that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpressed genes in ...

... ); 293748. 2015 AACR. Introduction demonstrate intratumoral lymphangiogenesis that is associated with ...

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O Criador:: Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.
Descrição:: Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...
Tipo:: Article

The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan

Correspondências de palavras-chave:: ... beneficial effects of B. subtilis lifespan Chelsey L Arvin 1, Zachary Sibila 2, Regina Lamendella 3, Jason ...

... block the beneficial effects of Bacillus subtilis on C. elegans lifespan. We found that loss of cgt-1 or ...

... phenotype of B. subtilis. However, cgt-1(ok1045) and cgt-3(tm504) did play a minor role in blocking stress ...

... of glucosylceramides in host-bacterial interaction. 4/5/2023 - Open Access Figure 1. Loss of CGT ...

... mutants (cgt-1(tm1027), cgt-1(ok1045), cgt-2(tm1192), cgt-3(tm504)) fed on E. coli (OP50; yellow) or B ...

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O Criador:: Arvin, Chelsey L., Sibila, Zachary, Lamendella, R., Chan, Jason, and Staab, Trisha
Descrição:: Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt...
Tipo:: Article

Investigating Epidermal Interactions Through an In Vivo Cutaneous Wound-Healing Assay

Correspondências de palavras-chave:
O Criador:: Doci, Colleen, Mikelis, C, Akwii, R, and Zemkewicz, J
Descrição:: Cutaneous wound healing is an intricate and multifaceted process. Despite these complexities, the distinct phases of wound healing provide a unique opportunity to evaluate the roles of different targets in these coordinated...
Tipo:: Part of Book

The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging

Correspondências de palavras-chave:: ... , Margaret P. Peck4, Azia P. Kalil4, Samantha P. Bromley4, Daniel Raftery3, Jason P. Chan1 1 Department of ...

... Received: June 24, 2022 Accepted: February 1, 2023 Published: February 13, 2023 Copyright: 2023 Staab et ...

... analyzed longitudinal lipid changes in wild type animals compared to mutants at 1-, 5-, and 10-days of age ...

... animals exhibit increased triacylglycerols (TAG) at 10-days compared to 1-day, and decreased ...

... determinants of lifespan and disease conditions [1, 2]. For example, lipid classes including www.aging-us.com ...

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O Criador:: Staab, Trisha, McIntyre, Grace, Bromley, S., Raftery, D., Chan, Jason, Wang, L., Radeny, J., Bettcher, L., Guillen, Melissa, Peck, M. , and Kalil, A.
Descrição:: Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age...
Tipo:: Research Paper

ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis.

Diet of the Myotis Sodalis (Indiana Bat) at an Urban/Rural Interface

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.

Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

The functional loss of ceramide metabolism enzymes ceramide synthase and acid sphingomyelinase on lipid metabolism and healthspan

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma

The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan

Investigating Epidermal Interactions Through an In Vivo Cutaneous Wound-Healing Assay

The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging

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