Martin, Leslie E., Jones, Colleen L., Hasina, Rifat, Jalil, Asif, Lingen, Mark W., and Kasza, Kristen

Despite numerous advances, the 5-year survival rate for head and neck squamous cell cancer (HNSCC) has remained largely unchanged. This poor outcome is due to several variables, including the development of multiple primary...

Article

Kot, Amanda, Nicholson, Jody, Black, Matt, Abbott, Matthew J., Wilson, Jon, Thomas, Adam, Schaffer, Benton, Fultz, Brandon, Benson, David P., and Burrows, Mallory

Castor canadensis Kuhl (North American beavers) are central place foragers who
collect woody plants and building materials from their surroundings and return to a main body of water containing a lodge or food cache. It has...

Article

Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi

NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...

Article

McInturf, S., Mendoza-Cozatl, D., Collins, Carina, Chlebowski, M., Gassman, W., Su, J., Cseke, L., and Spears, B.

The plant-specific TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR (TCP) transcription factor family is most closely associated with regulating plant developmental programs. Recently, TCPs were also shown to mediate host...

Article

Tuttle, Nicole M., Sparks, Dale W., and Benson, David P.

We conducted a study of the diet of the federally endangered Indiana bat (Myotis sodalis) at an urban/rural interface near Indianapolis International Airport in summer 2004. We used two 1-m2quadrats covered with window...

Article

Singh, Bhuvanesh, Marsh, Christina A., Sinha,Uttam K., Rusling, James F., Malhotra, Ruchika, Veenstra, Timothy D., Doci, Colleen L., Gutkind, J. Silvio, Patel, Vyomesh, Nathan, Cherie-Ann O., Martin, Daniel, and Molinolo, Alfredo A.

OBJECTIVES: The diagnosis of cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) patients constitutes an essential requirement for clinical staging and treatment selection. However, clinical...

Article

Mankame, Tanmayi P., Zhou, Guolin, Wroblewski, Kristen, Lingen, Mark W., Doci, Colleen L., and Hasina, Rifat

Despite recent therapeutic advances, several factors, including field cancerization, have limited improvements in long-term survival for oral squamous cell carcinoma (OSCC). Therefore, comprehensive treatment plans must include...

Article

McIntyre, Grace, Wong, Hoi Tong, Chan, Jason, Wright, Justin, and Lamendella, Regina

Objective

Many C. elegans aging studies use the compound 5-fluro-2ʹ-deoxyuridine (FUdR) to produce a synchronous population of worms. However, the effects of FUdR on the bacterial gene expression of OP50 E. coli, the primary...

Article

Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace

Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...

Article

Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan

G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...

Article

Martinez-Acosta, Veronica, G., Chan, Jason P. (Marian University - Indianapolis), Illig, Kurt R., McFarlane, Hewlet G., Favero, Carlita B., Basu, Alo C., Becker, Lora A., Morrison, Mary E., Bayline, Ronald J., Banks, Susan M.L., Tong, Michelle T., Chase, Leah A., Griffin,Gerald D., Rose, Jacqueline K., and Robinson, Siobhan

We join our voices with countless others across the country in an unequivocal condemnation of police brutality, institutionalized racism, and all forms of anti-black violence. As a scientific community, we acknowledge that our...

Wang, Lou, Staab, Trisha, Radeny, J, McIntyre, Grace, and Chan, Jason

The increase in our aging population in combination with the growing incidence of late-life conditions presents a need for research on healthy aging. Here, we present work examining the roles of sphingolipid metabolism on...

Conference Proceeding

Mikelis, Constantinos M., Doci, Colleen L., Gutkind, J. Silvio, Lionakis, Michail S., and Molinolo, Alfredo A.

Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably...

Article

Denton, Robert Daniel , Mueller, R. L., and Adams, A. N.

Transposable elements (TEs) are sequences that replicate and move throughout genomes, and they can be silenced through methylation of cytosines at CpG dinucleotides. TE abundance contributes to genome size, but TE silencing...

Article

Zhou, Guolin, Lingen, Mark W., and Doci, Colleen L.

BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...

Article

Arvin, Chelsey L., Sibila, Zachary, Lamendella, R., Chan, Jason, and Staab, Trisha

Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt...

Article

Main, Kegan A., Mikelis, Constantinos M., and Doci, Colleen L.

Re-epithelialization after cutaneous injury is a complex and multifaceted process that incorporates numerous cellular components interacting in a myriad of pathways. One of the most crucial aspects of this process is the...

Article

Doci, Colleen, Mikelis, C, Akwii, R, and Zemkewicz, J

Cutaneous wound healing is an intricate and multifaceted process. Despite these complexities, the distinct phases of wound healing provide a unique opportunity to evaluate the roles of different targets in these coordinated...

Part of Book

Choe, David, MacLean, A. G., and Delery, Elizabeth

Klotho is a regulatory anti-aging protein that is significantly expressed in the choroid plexus, plays an important role in regulating the immune response in the CNS, and diminishes with age. It is known that a decline of...

Article

Lulla, V., Johnson, G., Peterman, W. E., Langen, T. A., Denton, Robert, McCluskey, E. M., Fries, A. C., Strysozowksa-Hill, K. M., Mockford, S. W., and Gonser, R. A.

Context: Regional conservation efforts should incorporate fine scale landscape genetic and habitat suitability data for management decisions. This information permits conservation measures to be tailored to a specific...

Article

Johnson, G., Fries, A. C., Peterman, W. E, Mockford, S. W., Langen, T. A., Strysozowksa-Hill, K. M., Gonser, R. A., Denton, Robert D., Lulla, V., and McCluskey, E. M

Context: Regional conservation efforts should incorporate fine scale landscape genetic and habitat suitability data for management decisions. This information permits conservation measures to be tailored to a specific...

Article

Staab, Trisha, McIntyre, Grace, Bromley, S., Raftery, D., Chan, Jason, Wang, L., Radeny, J., Bettcher, L., Guillen, Melissa, Peck, M. , and Kalil, A.

Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age...

Research Paper

Benson, David P.

The White-tailed Ptarmigan (Lagopus leucurus) is one of the few socially monogamous species within the highly polygynous grouse subfamily (Tetraoninae). I found White-tailed Ptarmigan in Glacier National Park, Montana,...

Article

Long, S., Li, X., Chen, H., Ding, W., Guo, S., Wei, L., Doci, L. Colleen, Wu, Y., Ming, W., Wen, X., Bible, P. W., Deng, Y., Long, Y., Deng, X., and Wang, Z.

AIMS: Recent studies have suggested a possible association between microbiota and gestational diabetes (GDM). However, the results are inconsistent. Our objective was to investigate further the relationship between GDM and...

Article

Ahmad, Azeem and Akbar, Samina

The goal of this research was to determine the effects of the growth of invasive plant Amur Honeysuckle (Lonicera maackii) on the rhizosphere bacterial community composition, and diversity in an urban wetland forest ecosystem....

Article

Benson, David P. and Cummins, M.

ABSTRACT.—Because of the “montane island” effect and relative rates of climate change, alpine species may be particularly affected by changing climate. White-tailed Ptarmigan (Lagopus leucura) are adapted to life in the alpine...

Article

Zhou, G., Doci, Colleen L., and Lingen, M.W.

Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...

Article

Wilson, Kristy J.

Abstract
The online environment poses a number of challenges, including creating
opportunities for students to interact and get to know each other. I propose
adding online discussions that can allow students to explore the...

Article

Stegemann, Katherine A., Collins, Carina, Melena, I., King, C., and Greenwood, K.

Phloem is a critical tissue that transports photosynthates and extracellular signals in vascular plants. Although a functional phloem is necessary for plant health, it is also an ideal environment for pathogens to access host...

Article

Butler, K. J. , Collins, Carina A. , and Robison, J. D.

We argue that one of the best ways to improve equity and diversity in the plant sciences begins in the undergraduate
classroom. Our classrooms are the first stop for the next generation of plant scientists, and we must engage...

Article

Wilson, Kristy J. and Kinkade, Karla B.

Practitioners of course-based undergraduate research experiences (CUREs) often evaluate student learning through journal article style lab reports. In our biology department, CUREs are used in multiple required and elective...

Part of Book

Wilson, Kristy J. and Rigakos, Bessie

The scientific process is nonlinear, unpredictable, and ongoing. Assessing the nature of science is difficult with methods that rely on Likert-scale or multiple-choice questions. This study evaluated conceptions about the...

Article

Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia

Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...

Article

Doci, C. L., Molinolo, A. M., Gutkind,J. S., Callejas-Valera,J. L., and Mikelis, C. M.

SEMA3F is an antilymphangiogenic signaling molecule expressed in the proliferating basal layer of normal epithelium. In orthotopic models of head and neck squamous cell carcinoma, loss of SEMA3F or its receptors results in...

Article

Doci, Colleen L., Gutkind, J. Silvio, and Sakurai, Atsuko

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer....

Article

Doci, Colleen L. and Gutkind, J. Silvio

HPV is the most common sexually transmitted infection and it is predicted that up to 80 % of Americans will have HPV infections in their lifetime. The etiology of cervical cancer has long been linked with persistent HPV...

Book

Brycky, J, Brislawn, C, Chan, Jason, Heibeck, N, Letson, G, Buonaccorsi, V, Unverdorben, L, Emlet, C, Chen See, J, and Lamendella, R

Article

Onaitis, Mark W., Asselin-Labat, Marie-Liesse, Gutkind, J. S., Uchiyama, Akihiko, Callejas-Valera, Juan Luis, Abusleme, Loreto, Molinolo, Alfredo A., Edwards, Dean, Moutsopoulos, Niki M., Iglesias-Bartolome, Ramiro, Morasso, Maria I., Doci, ColleenL., and Brooks, Stephen R.

Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We...

Article

Doci, Colleen L., Gutkind, J. Silvio, and Sakurai, Atsuko

Semaphorins are a family of membrane-bound and secreted type of proteins which were initially identified as chemorepulsive axon guidance molecules. Plexins and neuropilins are two major receptor families of semaphorins, and...

Article

Timmerman, K. M., Doci, C. L., Main, K. A., Angarita, P. A., Wilson, K. J., Gabbard, D. B., and Kinkade, K.B.

This laboratory experiment, designed for undergraduate nonmajors or advanced high school students, attempts to demystify the technique of spectrophotometry by utilizing a hands-on, real-world approach. Modification of the...

Article