Children with acute lymphoblastic leukemia
(ALL) suffer a litany of therapy induced side
effects. Methotrexate is a common chemotherapy agent
administered for the treatment of ALL. Failure to clear methotrexate from the body...
Background: It has been observed that patients with poor mental health are relatively frequent users of the Emergency Departments (ED). The objective of this study was to evaluate the prevalence of numerous behavioral health...
Background: Due to globalization, spread of a pandemic is inevitable as we have seen with COVID-19. Further, increased ease of travel increases the potential and frequency of pandemics. Hence, it is imperative to find solutions...
The United States spends well over $100 billion for millions of people affected by Alzheimer’s disease and related dementias (ADRD) and for their family caregivers. Most people with ADRD have multiple chronic comorbid...
The chapter opens with a discussion of the Great Railroad Strike of 1877 in which questions regarding the social order, class, equity, and like matters arise. The coincidental arrival in Indianapolis of Denis Kearney and the...
Presented in the Innovative Assessment of Learning track. and MAT250 transitions students to advanced mathematics. Objectives include learning to justify mathematical statements using standard methods of proof and communicate...
Background: The implementation of a standardized warming protocol aims to prevent hypothermia in the postoperative period. Hypothermia in the postoperative period can result in inadvertent adverse outcomes for patients...
Medication errors and interactions happen every day in the perioperative setting. It is the responsibility of the post-anesthesia care unit (PACU) nurse to manage pain, nausea, vomiting, and maintain hemodynamics after surgery...
Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super...
A presentation at the 2017 Higher Education Partnership: Internationalization in the Americas conference in San Miguel de Allende, Mexico (sponsored by the Partners of the Americas organization). This presentation outlines the...
Background: Many surgical procedures require muscle paralysis of the patient to ensure optimum operating conditions. Monitoring the level of paralysis is an important responsibility of the nurse anesthetist throughout...
The LGBT+ community is generally grouped into one big group with all the same needs by media, organizations, and people. However, LGBT+ people have different concerns and needs based on age, race, ability, and so many other...
This article is an invitation to Christian youth and young adult educators and ministers to be more understanding of queer theology and to discern its place within ministry to and for young people. The article examines the term...
Healthcare disparities among different racial and ethnic groups are prevalent across the United States and worldwide. Healthcare provision may differ among racial and ethnic minorities, socioeconomic statuses, and insurance...
Recent studies describe racial and socioeconomic
(SES) disparities with mechanical thrombectomy
(MT) for acute ischemic stroke (AIS). Our study
investigated whether such disparities are present at
our institution and...
Over 1.25 million people reside in nursing facilities in the United States. Nursing facilities have reported 268,707 confirmed cases of COVID-19 and 61,765 COVID-19 deaths as of the week of November 2, 2020. Indiana was one of...
Presented in the Active/Collaborative Learning track. and Student engagement and collaborative learning is enhanced by following the customized Internship Playbook. A large population of the students in the School of Business...
This article discusses the collaborative digitization effort between librarians at Marian College (now Marian University) and Indiana University Purdue University Indianapolis (IUPUI) to create a deliverable online collection...
Exploring the intersection between Chicago's eight-hour movement and Protestant religious culture over a fifty-year span, this project considers how workers and clergy contested the religious meaning of the eight-hour system...
This article presents seven points of focused dissonance between Jeremiah and Romans, by identifying how Romans 9–11 inverts the judgment language of Jeremiah 1–20 against Judah. Without claiming that the inversions in Romans...
In the intraoperative setting, the intersection of hand hygiene practices and contamination of the anesthesia workstation presents a critical juncture for reducing hospital acquired infections that ultimately lead to increased...
Background: The lack of palliative care (PC) services poses a significant risk for PC patients. Research indicates that patients' needs often go unmet when PC referral processes are not well established within a health system....
Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and...
Introduction Delayed vasopressor initiation can occur with septic patients who arrive to the emergency department (ED) hemodynamically stable but decompensate later in their ED or hospital course. The relationship between...
Religion Matters: How Sociology Helps Us Understand Religion in Our World focuses on religion’s interplay with broader society, introducing students to the basic questions, ideas, and methods with which sociologists have...
Practitioners of course-based undergraduate research experiences (CUREs) often evaluate student learning through journal article style lab reports. In our biology department, CUREs are used in multiple required and elective...
In 1984, Ultrasound-Guided (USG) Intravenous (IV) access was first used to place central venous catheters (CVC) in real-time. This led to increased success rates, reduced procedural times, decreased site associated...
Community Health Needs Assessments and the developed strategies corresponding to any findings provide opportunities to improve the health of communities by targeted, coordinated efforts to meet the community needs. Thomas...
Background and Review of Literature: Postoperative nausea and vomiting (PONV) frequently occur in patients after anesthesia, significantly impacting patient satisfaction and potentially leading to untoward complications....
Background and Review of Literature: Caesarean sections are one of the most performed procedures in the operating room. Managing pain for these patients is vital to ensure a positive birthing experience for mothers and...
In his book, Music Education in an Age of Virtuality and Post-Truth, Woodford presents a welcomed discussion of the aims of music education in a time of political unrest. This timely text is needed due to the stresses of the...
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. While significant advances in the...
Coxiella burnetii is an obligate intracellular bacterium responsible for causing culture negative endocarditis. The manifestation of this condition several years following initial infection exhibits Coxiella’s ability to...
While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
Bradykinin, a local dermal kallikrein-kinin system product, increases skin blood flow via a cyclic GMP mechanism but is not the active cutaneous vasodilation molecule associated with cholinergic stimulation. However, the...
There is a need for anabolic therapies to treat degenerative bone
diseases. Mechanical loading stimulates anabolic and inhibits
catabolic pathways of bone leading to increased bone formation.
Osteocytes are the bone cell...
Obesity and metabolic dysfunction negatively impacts many tissues, including the skeleton. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase and key regulator of whole-body...
Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage diagnoses...
•Head and neck squamous cell carcinomas (HNSCCs) have remained one of the common and lethal cancers around the world. •HNSCC rapidly spread via the lymphatics system, leading to a higher percentage of initial late-stage...
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While Coxiella initially infects alveolar macrophages, it may disseminate and cause endocarditis up to 20...
Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy
(cART)?
• The brain is a known reservoir for HIV.
• HIV can act on myeloid cell populations like...
Context: Lipid droplets (LDs) are cytoplasmic lipid storage organelles that have recently gained importance in host-pathogen interactions. They are surrounded by a phospholipid monolayer and store excess cellular free fatty...