The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
The unique conditions of microgravity and radiation exposure in space have a substantial impact on human tissue function, resulting in extreme bone loss. The goal of this project is to synthesize the current knowledge on bone...
Context. Metabolic syndrome (MetS) refers to the combination of abdominal obesity, hyperglycemia or insulin resistance, dyslipidemia, and hypertension. MetS has been associated with morbidity and mortality after a variety of...
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α<sub>2</sub>δ<sub>1</sub> VSCC subunit regulates osteocyte...
Stomach dehiscence from the abdominal wall is a serious and potentially life-threatening complication of gastrostomy tube changes. A prospective series of 1136 gastrostomy tube changes in 415 different patients is examined to...
Introduction: According to the Centers for Disease Control and prevention (CDC), ensuring student access to needed physical and mental health care improves attendance, behavior, and achievement in the classroom. Academic...
Neurosurgical procedures result in surgically-induced brain injury (SBI) that causes postoperative complications including brain edema and neuronal apoptosis in the surrounding brain tissue. SBI leads to the release of...
Multiple drug resistance is becoming increasingly problematic in the U.S., where antibiotics are overused both in agriculture and healthcare. One way bacteria can develop this resistance is through acquisition of antibiotic...
300 targets using very small quantities of protein. This revealed decreased activation of the mTOR pathway in tibiae of Nmu knock-out mice compared to controls, with reduced activity-associated phosphorylation of mTOR and the...