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Filtrage par: Mot-clé Bone Morphogenetic Protein Receptors Supprimer la restriction Mot-clé: Bone Morphogenetic Protein Receptors

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Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Créateur:

Frump, A.L., Hamid, R., Lowery, Jonathan W., Austin, E.D., and de Caestecker, M.

La description:

More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...

Type:

Article
BMP Signaling in Vascular Development and Disease.

Créateur:

de Caestecker, M. and Lowery, Jonathan W.

La description:

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...

Type:

Article
BMPR-II is Dispensable for Formation of the Limb Skeleton.

Créateur:

Beppu, H., Lowery, Jonathan W., Rosen, V., Tsuji, K., Cox, K., Capelo, L.P., and Gamer, L.W.

La description:

Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...

Type:

Article
Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

Créateur:

de Caestecker, M., Frank, D.B., Lowery Jonathan W., Reese, J., Anderson, L., and Brink, M.

La description:

Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...

Type:

Article
Loss of BMPR2 Leads to High Bone Mass Due to Increased Osteoblast Activity

Créateur:

Intini, G., Lotinun, S., Ote, S., Lowery, Jonathan W., Rosen, V., Cox, K., Salazar, V., Baron, R., and Gamer, L.

La description:

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...

Type:

Article
N-linked Glycosylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) Enhances Ligand Binding

Créateur:

Amich, J.M., Lowery, Jonathan W., Rosen, V., and Andonian, A.

La description:

The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...

Type:

Article
The Role of BMP2 Signaling in the Skeleton.

Créateur:

Intini, G., Lowery, Jonathan W., Rosen, V., Pazin, D., Chappuis, V., Capelo, L.P., and Kokabu, S

La description:

While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...

Type:

Article

Limiter votre recherche

Type

Generic Work7

Type de ressource

Article7

Créateur

Lowery, Jonathan W.6
Rosen, V.4
de Caestecker, M.3
Capelo, L.P.2
Cox, K.2
plus Créateurs »

Mot-clé

Bone Morphogenetic Protein Receptors[remove]7
Type II4
Activin Receptors3
Familial Primary Pulmonary Hypertension3
Signal Transduction3
plus Mot-clés »

La langue

English7

Collection

Faculty Publications and Research - MUCOM7

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