Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.

More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...

Article

Lowery, Jonathan W. and de Caestecker, M.

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...

Article

Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.

Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...

Article

Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.

Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...

Article

Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...

Article

Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.

The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...

Article

Capelo, L.P., Chappuis, V., Kokabu, S, Lowery, Jonathan W., Rosen, V., Pazin, D., and Intini, G.

While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...

Article