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Bone Morphogenetic Protein Receptors

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Faculty Publications and Research - MUCOM

1. Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Keyword-Übereinstimmungen:
Schöpfer:: Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
Beschreibung:: More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
Ressourcentyp:: Article

2. BMP Signaling in Vascular Development and Disease.

Keyword-Übereinstimmungen:
Schöpfer:: Lowery, Jonathan W. and de Caestecker, M.
Beschreibung:: Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...
Ressourcentyp:: Article

3. BMPR-II is Dispensable for Formation of the Limb Skeleton.

Keyword-Übereinstimmungen:
Schöpfer:: Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.
Beschreibung:: Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...
Ressourcentyp:: Article

4. Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

Keyword-Übereinstimmungen:
Schöpfer:: Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.
Beschreibung:: Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...
Ressourcentyp:: Article

5. Loss of BMPR2 Leads to High Bone Mass Due to Increased Osteoblast Activity

Keyword-Übereinstimmungen:
Schöpfer:: Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.
Beschreibung:: Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
Ressourcentyp:: Article

6. N-linked Glycosylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) Enhances Ligand Binding

Keyword-Übereinstimmungen:
Schöpfer:: Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.
Beschreibung:: The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...
Ressourcentyp:: Article

7. The Role of BMP2 Signaling in the Skeleton.

Keyword-Übereinstimmungen:
Schöpfer:: Capelo, L.P., Chappuis, V., Kokabu, S, Lowery, Jonathan W., Rosen, V., Pazin, D., and Intini, G.
Beschreibung:: While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
Ressourcentyp:: Article